49ers vs. Cardinals Player Props & TD Scorer Bets: Rushing in Focus on MNF

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Two NFC West teams battle it out on Mexican soil to close out Week 12 of the 2022 NFL season. The two teams in question are the San Francisco 49ers (5-4) and Arizona Cardinals (4-6), who face off on the Monday Night Football stage.

This primetime divisional clash features a bunch of star names and is a fun spot to wager on player props and anytime touchdown scorer bets.

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San Francisco 49ers vs. Arizona Cardinals MNF Odds

Oddsmakers view San Francisco – priced between -400 and -480 on the moneyline as of Monday evening – as a large favorite, as the 49ers are laying 10 points against the “home” team. Arizona’s odds range from +310 and +360.

The Cards have followed each of their three wins this season with back-to-back losses. Given they won their last contest and are sizable underdogs tonight, Arizona may be in trouble.

DraftKings bettors have mixed feelings about this game, with the Niners receiving 79% of moneyline tickets but just 41% of spread tickets.

The Over/Under total for this tilt sits between 43 and 43.5 points on legal US sports betting apps.

SF 49ers vs ARI Cardinals Odds NFL Odds

NFL · Mon (11/21) @ 8:15pm ET

SF 49ers at ARI Cardinals
State Farm Stadium, Glendale, Arizona

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Player Props, TD Scorer Bets for MNF Week 11

Christian McCaffrey Under 63.5 Rushing Yards (-110, Fanduel),  Anytime TD Scorer (-140, BetMGM)

One of the most shocking storylines of Week 10 was that Elijah Mitchell out-carried and out-gained McCaffrey in the former’s first game back since the season opener. McCaffrey has now compiled 38 yards rushing in two of his three games since moving to San Francisco.

We have Christian McCaffrey (23) scoring a touchdown but going Under on his Week 11 rushing prop against the Arizona Cardinals in Week 11 MNF. (AP Photo/Kyusung Gong)

Head coach Kyle Shanahan wants these two backs to split backfield work going forward, so unless McCaffrey has a hyper-efficient day running the ball, he’ll likely finish with fewer than 67-plus yards.

Although he handled 14 carries to Mitchell’s 18, McCaffrey had five of the team’s seven goal-line snaps against Los Angeles and scored a short touchdown, which is why it’s very possible he falls short of his rushing prop and still finds the end zone.

The Niners’ new toy has scored in each of his last two games (three touchdowns total), and is a quality candidate to make it three straight games.

McCaffrey is one of the most versatile players in the sport, which has helped him score both on the ground and through the air. Arizona has one of the league’s worst red zone defenses, allowing a league-worst 2.7 red zone touchdowns per game, so he’ll have plenty of chances to score six points.

Also read: 49ers vs. Cardinals Odds & Prediction

James Conner Under 50.5 Rushing Yards (+102, Caesars)

Conner has gone Under on his Week 11 rushing prop total in five of his nine games this season, and now faces one of the league’s toughest rushing defenses in the Niners.

San Francisco allows the second-fewest rushing yards in the NFL (82.7 per game) and has shut down some of the league’s top running backs, including Austin Ekeler (24 yards) just last game.

The 49ers haven’t surrendered 50-plus yards on the ground to a single player since Week 6. Conner may be phased out of the game by the time the second half rolls around, which sets bettors up for a quickly cashed bet.

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Jimmy Garoppolo Over 1.5 Rushing Yards (-115, BetMGM)

The beauty about backing immobile quarterbacks’ low rushing prop totals is that it often takes just one play for bettors to cash in their tickets. In the case of Garoppolo, he has run for at least a couple of yards in four straight contests, which is just what the doctor ordered.

Immobile quarterbacks have been comfortable running the ball against the Cardinals. In fact, only one quarterback has failed to reach two-plus yards rushing. Some notable slow-pokes that have found success using their legs are Kirk Cousins (22 yards and a touchdown), Dalton (21 yards), and Derek Carr (nine yards).

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DeAndre Hopkins Over 75.5 Receiving Yards (-110, FanDuel), Over 6.5 Receptions (+115, Caesars)

Hopkins is off to a very hot start after serving his six-game PED suspension. Arizona’s top skill player has caught 10-plus balls for 98-plus receiving yards in three of his four games this season. He leads the league in receptions (36) over the past four weeks.

San Francisco focuses most of its defensive attention towards stopping the run, and while the Niners have been fine in passing defense, they’ve had trouble containing star receivers. Cooper Kupp went for a buck 22 against San Francisco in Week 4, and Tyler Lockett posted 107 yards receiving back in Week 2.

“Nuk” might not have a monster performance, but from the way he’s been balling out recently, it’ll be extremely hard for the 49ers to hold him Under his Week 11 receiving prop totals.

Also read: Super Bowl Odds

About the Author
Cyrus Eshaghoff

Cyrus Eshaghoff

Sports Betting Writer
Cyrus Eshaghoff is a New York-based sports writer. Whether it's heated debates or uncovering statistical insights, he loves discussing sports. Check out his Twitter account (@CyrusEshaghoff).

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