49ers vs. Rams Odds & Prediction: This San Francisco Fact Will Surprise You

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The San Francisco 49ers are scheduled to play the Los Angeles Rams at SoFi Stadium on Sunday afternoon in Week 8 of the 2022 NFL season.

The line opened last week with the Rams a 2.5-point favorite. But now the 49ers are favored by 1.5 at the DraftKings, FanDuel, PointsBet, and BetMGM betting sites.

Let’s take a look at the latest 49ers vs. Rams odds on Sunday as well as our prediction.

NFL Odds: Point Spread, Moneyline, Total

Here are 49ers vs. Rams odds from around the sports betting marketplace.

49ers Looking to Continue Dominance Against Rams

Over the past four seasons, San Francisco has gone 7-1 vs. LA (8-0 against the spread), with its loss coming in last year’s NFC title game at SoFi, 20-17, as a 3.5-point dog.

But in their past three regular-season meetings in LA, dating to 2019, the 49ers have won as an underdog.

In Week 4 this year in San Francisco, the 49ers held the Rams without a touchdown in a 24-9 victory as a 2-point favorite, sacking Rams QB Matthew Stafford seven times. No QB in the league has gone down that often in a game since and Stafford also threw a pick-six.

Injuries have taken a toll at times for a 49ers team that has lost two straight and is 3-4 (3-4 ATS, too) and trails surprise NFC West leader Seattle (4-3) by a game.

49ers vs. Rams Odds & Prediction: This San Francisco Fact Will Surprise You
San Francisco RB Christian McCaffrey is expected to make an impact in our 49ers vs. Rams odds & prediction. (AP Photo/Lachlan Cunningham)

Back in the lineup is leading sacker Nick Bosa (with seven), who sat out the team’s Week 6 upset loss in Atlanta. And All-Pro OLT Trent Williams also has returned to fortify the run game and pass protection.

The Rams, meanwhile, are 3-3 (2-4 ATS) and completing a three-game homestand wrapped around last week’s bye. Teams with that extra rest, however, have gone only 12-14-1 ATS the past two seasons vs. a squad that played the week before. So, no apparent edge there.

Stafford’s numbers this year have been awful compared with last season’s and surely have given fantasy owners fits. He has thrown only six TD passes with eight interceptions. Last season during the team’s run to the Super Bowl, he had 41 scoring throws with 17 INTs (with those picks tied for most in the league).

A reason for his troubles could well be because of issues along the offensive line, which lost two-time All-Pro OLT Andrew Whitworth to retirement in the offseason and then his replacement, Joe Noteboom, to an Achilles injury this season. That’s just for starters. He’s among four guys who were in the opening-day lineup, a 31-10 loss to Buffalo, who are now on IR or in concussion protocol.

Somehow WR Cooper Kupp continues to be a weapon roaming in enemy secondaries with 56 receptions, one off the league lead despite having that bye. In that game against SF four weeks ago, he had 14 catches on 19 targets for 122 yards.

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49ers vs. Rams NFL Prediction

Until the 49ers were pummeled last week by Kansas City 44-23 and yielded 529 yards, they had the No. 1 ranked defense in the league.

Despite that carnage, San Fran still stands third on the chart and will be going against a Rams offense that’s ranked 26th.

On top of Stafford’s troubles, the running game is producing only 70.5 yards a game, the second worst in the NFL.

Meanwhile, the 49ers just added former All-Pro RB Christian McCaffrey to the mix in a trade last week with Carolina. He joins TE George Kittle, WR/RB Deebo Samuel, and QB Jimmy Garoppolo (sixth in the league at 7.9 yards a throw) to make San Francisco a bigger offensive threat than usual.

Prediction: 49ers 26, Rams 13

Also read: NFL Week 8 betting tips and strategies | NFL Week 8 betting picks and predictions

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, is a sports betting writer at Gaming Today. He has been a gaming writer (primarily for the NFL) for more than four decades, with his work appearing in publications and websites across North America. Christ is a big fan of the Arkansas Razorbacks, Philadelphia Eagles and Phillies, and the NHL's Winnipeg Jets.

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