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The Los Angeles Chargers are scheduled to play the Colts in Indianapolis on Monday night to close out play in Week 16 of the 2022 NFL season.

In May, when the odds first were posted for this game, it was listed as pick ’em, but the Chargers now are favorites by 4.5 to 5 points on the DraftKings, FanDuel, BetMGM, and PointsBet wagering sites.

Chargers vs. Colts Betting Lines: Point Spread, Totals, Moneyline

Here are current odds from top US sports betting apps. It’s always recommended to shop around various sportsbooks to find the best prices for your bets and to take advantage of multiple sportsbook bonuses.

LA Chargers vs IND Colts Odds NFL Odds

NFL · Mon (12/26) @ 8:15pm ET

LA Chargers at IND Colts
Lucas Oil Stadium, Indianapolis, Indiana

Up to $1,000 risk-free bet at BetMGM

Where the Chargers and Colts Stand Heading Into Week 16

Both teams are coming off games with the outcome determined by field goals in the final seconds: LA won at home versus Tennessee and Indy lost at Minnesota in record-setting fashion.

The Chargers are 8-6 (8-5-1 against the spread) and currently hold the second wild-card spot in the AFC. Considering they have by far the easiest remaining schedule according to (Rams and Broncos are up next), it seems assured they’ll reach the playoffs after last season’s agonizingly close-call miss. Their odds to make this postseason are -700 at BetMGM.

The Colts (4-9-1 SU/6-8 ATS), meanwhile, have the worst record for any team still in contention for a postseason berth (+10000 DraftKings). They can’t squeeze in via the wild-card route but still could win the AFC South thanks to frontrunning Tennessee’s four straight defeats to nose-dive to a 7-7 record.

Of course, by the time Indy takes the field Monday night, it could be eliminated if the Titans beat visiting Houston on Saturday. Tennessee is a 3- to 3.5-point favorite.

Indianapolis will be benching the NFL’s turnover king, QB Matt Ryan, yet again on Monday night and giving former Philadelphia Eagles Super Bowl hero Nick Foles his first start of the season. Ryan has 18 giveaways this year, including a league-high 13 INTs. He had previously lost his job at midseason to Sam Ehlinger but got it back after two games when interim head coach Jeff Saturday took charge.

Foles will be operating without last year’s rushing champ, Jonathan Taylor, who is likely out for the year with an ankle injury. He averaged 4.5 yards a carry while gaining 861 yards this year. The rest of the team has a norm of 3.5.

As for the Chargers. although they have won three of their past four to enhance their playoff chances, they’ve been outscored by 28 points this year, the greatest negative margin for any team with a winning record. Puzzling.

LA’s rush defense gets much of the blame by allowing 5.4 yards a carry, tied for worst in the league.

On offense, with star WRs Mike Williams and Keenan Allen back together after injury-filled seasons, they have teamed for 410 yards in the past two games. And now they’ll get to sift through a Colts pass defense (ranked 27th) that allowed Minnesota’s Kirk Cousins to throw for 417 yards in the second half of last week’s NFL-record comeback from a 33-0 deficit to win 39-36 in OT.

Now, Indy will have to deal with LA quarterback Justin Herbert, who has thrown for more than 4,000 yards already this year, second-most in the league.

Check updated numbers: NFL playoffs odds | Super Bowl 57 odds

Chargers vs. Colts Injuries

Veteran Titans veteran QB Ryan Tannehill likely will miss the rest of the season with an ankle injury.

Two of the Chargers’ injured defensive stalwarts, LB Joey Bosa (groin) and safety Derwin James (quad), could be returning soon, but probably not this week. Both are listed as questionable

Line moves: NFL Week 16 odds

MNF Prediction

While the Colts will be undermanned in the rushing department, LA comes out way ahead here with RB Austin Ekeler, who is tied for the league lead with 14 overall touchdowns. He has nine rushing and five receiving TDs, which is tops on the team in both categories.

With Williams and Allen occupying the attention of the DBs, he could find plenty of open spaces.

Also, is that Colts defense running out of gas? In their past two outings, they have blown fourth-quarter leads while being outscored 55-0. Included was a defensive fumble return for a score.

Another thing or two:

Sure, the Chargers have to endure travel across three time zones East for this one, but they won’t be operating on a short work week like the Las Vegas Raiders, who will be playing in Pittsburgh on Saturday.

For whatever reason(s), Western teams in this cross-country travel scenario have gone 21-8-1 ATS and 22-8 straight up in the past two seasons. The Chargers have helped lead the way, going 5-1 ATS/SU in that span, including spread-beating triumphs as a favorite this year in Cleveland and Atlanta.

Forecast: Chargers 30, Colts 16

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About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, is a sports betting writer at Gaming Today. He has been a gaming writer (primarily for the NFL) for more than four decades, with his work appearing in publications and websites across North America. Christ is a big fan of the Arkansas Razorbacks, Philadelphia Eagles and Phillies, and the NHL's Winnipeg Jets.

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