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NFL Week 7 features a marquee matchup between the 4-2 Kansas City Chiefs and the 3-3 San Francisco 49ers. This is a battle between the Chiefs’ No. 1 offense and the 49ers’ No. 1 defense. The Chiefs remain a Super Bowl contender in the AFC, while the 49ers are hopeful a number of key players return from injury for this NFL Week 7 game. San Francisco’s offense, though, has been bolstered by the acquisition of Christian McCaffrey.

Let’s take a look at the betting odds, props, and predictions for the Kansas City Chiefs vs. San Francisco 49ers matchup.

Chiefs vs. 49ers Betting Lines: Point Spread, Moneyline, Total

Kansas City was priced as a -1.5 point favorite on look-ahead lines last week and re-opened -2.5 in Las Vegas on Sunday night. Bettors pushed that number as high as -3.5 at some sportsbooks. 49ers +3.5 of course was of interest to sharp bettors.

The point spread remained steady at -2.5 until news broke of the 49ers’ trade with the Carolina Panthers for McCaffrey. The line has since dropped to 49ers +2.

The total opened at 47.5 points, and bettors have leaned to the Over. The total has crept up to 48.5 at most sportsbooks.

Here are current odds from legal US sportsbooks on this NFL Week 7 showdown.

KC Chiefs vs SF 49ers Odds NFL Odds

NFL · Sun (10/23) @ 4:26pm ET

KC Chiefs at SF 49ers
Levi's Stadium, Santa Clara, CA

Our Pick: KC Chiefs at -1.5 (-110). Bet NFL at BetMGM: Use Promo Code TODAY for $1,000 Risk Free Bet

Kansas City Chiefs vs. San Francisco 49ers Betting News

The Chiefs opened their season as one of the Super Bowl betting favorites. A loss last week against the Buffalo Bills lengthened their odds slightly, as the Bills are looking more and more like a runaway for the No. 1 seed in the AFC.

The Chiefs enter this matchup against the 49ers with the NFL’s best offense, ranking first in total points per game. QB Patrick Mahomes sits third in passing yards, while his primary target TE Travis Kelce ranks seventh in total receptions through six weeks.

This explosive offense could spell trouble for a 49ers team dealing with a number of key injuries on defense. Defensive end Nick Bosa will be a game-time decision, and starting safety Jimmie Ward recently underwent surgery for a broken hand that could see him miss significant playing time.

The 49ers offensive tackle Trent Williams is likely to return to the lineup for this contest against the Chiefs. Williams has been a key part of this offensive scheme and will be a welcome addition after the 49ers lost to the Falcons in Week 6.

When healthy, the 49ers remain one of the most dangerous teams in the NFL. With the addition of McCaffrey, it’s clear the 49ers are making a push to compete this season. Don’t be surprised if San Francisco and their league-leading defense claim the NFC West and make a run at the No. 1 seed in a wide open NFC.

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Kansas City Chiefs vs. San Francisco 49ers Betting Trends

Kansas City Chiefs

  • The Chiefs are 4-1 straight up in their last five games against the 49ers
  • The Chiefs are 5-1 against the spread in their last six games against the 49ers
  • The Chiefs are 1-4 against the spread in their last five games
  • The total has gone OVER in 10 of the Chiefs’ last 15 games

San Francisco 49ers

  • The 49ers are 6-0 against the spread in their last six games at home
  • The 49ers are 5-0 straight up against the Chiefs at home in their last five games
  • The total has gone UNDER in eight of the 49ers’ last nine games
  • The 49ers are 8-4 against the spread in their last 12 games

Also read: NFL Week 7 Survivor Picks | NFL Week 7 Betting Strategies

Kansas City Chiefs vs. San Francisco 49ers Prediction

The Chiefs have thrived as short favorites with Mahomes under center. He’s 13-2-1 lifetime when laying less than 3 points in his short career.

There are two big question marks for the 49ers in this one:

Will newly acquired McCaffrey suit up for this contest? All signs point to yes. NFL’s Ian Rappaport reported Thursday that McCaffrey will join his new team, and will be featured only during red zone packages for the 49ers offense.

The second question mark is the 49ers injury report. San Francisco is a much more dangerous team when fully healthy. Bosa and Williams look likely to return, but will remain game-time decisions against the Chiefs. If both suit up, there’s no guarantee they perform at 100%.

Backing Mahomes and this Chiefs offense as short favorites has been a profitable strategy. The Chiefs will enter this game fired up after a tough loss to the Bills and should take advantage of a less-than-healthy 49ers team.

The Pick: Kansas City Chiefs (-2)

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Kansas City Chiefs vs. San Francisco 49ers Props

There are a number of betting props available for Chiefs vs. 49ers.

Deebo Samuel Anytime TD Scorer YES +125

Deebo Samuel has been one of the most dynamic players this NFL season. He’s averaging eight touches per game, both as a wide receiver and running back.

Samuel is a key piece of this 49ers offense. They’ll need to keep up with an explosive Chiefs team that leads the NFL in points scored. With a number of injuries to the 49ers front line, look for Head Coach Kyle Shanahan to get the ball into the hands of his best players. Samuel is one of them.

Samuel has three touchdowns scored through six games this season, which makes this closer to an even money proposition. Getting Samuel to score an anytime touchdown at plus money is good value.

Travis Kelce Anytime TD Scorer YES +105

The Chiefs tight end currently has seven receiving touchdowns on the year through six games. Four of them came against the Raiders, but Kelce is averaging seven receptions and more than 75 yards per game as Mahomes’ favorite target.

Against a 49ers defense dealing with injuries, look for Mahomes to get the ball to his favorite offensive target.  Kelce to score a touchdown at plus money is a great price.

Read more: NFL Week 7 Betting Trends

Chiefs vs. 49ers Broadcast and Game Day Information

  • Game Day: Sunday, October 23, 2022
  • Game Time: 4:25 p.m. ET
  • Location: Levi’s Stadium | Santa Clara, California
  • Channel: FOX

Also read: NFL Week 7 Odds | Super Bowl 57 Odds

About the Author
Jim Robinson

Jim Robinson

Jim Robinson is a sports betting writer at Gaming Today. An entertainment professional with 20 years of experience as an actor, writer, producer, and comedian, Robinson recently transitioned into the world of sports media as a writer and content creator. He has over 15 years of experience as a sports bettor, poker player, and card sharp. Robinson is proficient in all forms of betting and in-game wagering but his expertise is the PGA Tour.

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