Chiefs vs Bills Prediction, Odds, Best Bets: Buffalo Slight Home Favorite in NFL Divisional Round is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. Gaming Today may receive referral compensation from the sportsbook company when you claim a bonus offer or promotion through a link on this site. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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The Kansas City Chiefs continue their title defense when they visit the Buffalo Bills in the NFL Divisional Round, with the home team the slight favorite in the Chiefs vs Bills prediction, odds, and best bets.

Both teams achieved an 11-6 record during the regular season but a 20-17 Bills win at Arrowhead on Dec. 10 serves as the tiebreaker that puts this playoff encounter in Buffalo’s Highmark Stadium. A cloudy night in the low 20s is forecasted with kickoff set at 6:30 p.m. ET, televised nationally on CBS.


The spotlight will naturally be on the quarterback battle between Patrick Mahomes and Josh Allen, who last week rushed for a 52-yard touchdown. This will be the last NFL Divisional Round game to be played, and for that reason will likely see additional betting traffic from the public on the top-rated sports betting apps.

Let’s look at our favorite Chiefs vs Bills odds.

Read more: NFL Divisional Round anytime TD scorer bets | NFL odds | Super Bowl 58 odds

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Chiefs vs Bills Spread, Moneyline, Total

Here are the best available odds for moneyline, spread, and total across top sports betting apps. Click on the odds you like to place a bet. Learn more about sports betting promos when signing up to receive bonus bets.

Spread: Chiefs , Bills
Moneyline: Chiefs , Bills

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Chiefs vs Bills Betting Trends

  • Chiefs vs Bills ATS Records: Chiefs 10-7-1, Bills 8-10-0
  • Chiefs vs Bills Over/Under Records: Chiefs 7-11-0, Bills 5-13-0
  • Chiefs, Bills odds to win the AFC: Chiefs , Bills
  • Chiefs, Bills odds to win Super Bowl LVIII: Chiefs , Bills

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Chiefs vs Bills Player Props

Chiefs vs Bills Passing Odds

Patrick Mahomes and Josh Allen each threw for over 4,000 yards during the regular season, placing in the top six of passers across the league.

Mahomes is favored to hit the Over in his predicted yards, touchdown passes, attempts, and completions.

There is value on Allen, who threw for three TDs last week, with plus odds available on passing touchdowns.

Chiefs vs Bills Rushing Odds

Isiah Pacheco was the Chiefs’ go-to player in the rushing department with a team-leading 935 yards and 7 touchdowns. RBs Jerick McKinnon and Clyde Edwards-Helaire are the only other KC players that got into the endzone during the season but Pacheco is No. 1 by few miles. Pacheco looks like good value to score despite the Chiefs’ 19th ranked rushing game.

James Cook rushed for 1,122 yards during the regular season and is the clear top RB for Buffalo. If you’re looking for TD scorers, however, Josh Allen led the Bills with 15 rushing TDs and Latavius Murray was next with four. Regardless, Cook has good odds to score.

Chiefs vs Bills Receiving Odds

Travis Kelce and Rashee Rice lead the Chiefs in receiving yards and touchdowns, respectively. Rice got the lone touchdown catch against the Dolphins during the Wild Card round. Justin Watson , Noah Gray and Isiah Pacheco are also names to consider.

Stefon Diggs is top of the list for the Bills in receiving with 1,183 yards and eight touchdowns during the regular season. Diggs has not picked up a touchdown since November, which has him at plus odds to score . Gabe Davis has 7 TDs this season but is questionable. Dalton Kincaid , Dawson Knox , and Khalil Shakir all caught a TD against Pittsburgh and are names to consider.

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Chiefs vs Bills Analysis and Prediction

Is it finally the Bills’ time to shine? The Chiefs are the defending champs until someone knocks them out of the race and it hasn’t been Buffalo in recent playoff appearances.

Taking the regular season win from one month ago with a grain of salt, the Bills will feel great about their chances to parlay their home-field advantage to a trip to the AFC Championship game if they can continue their momentum. The Chiefs will be a much tougher test than the Steelers but the home team has enough to get another W.

Pick: Bills -3 (+102 at time of publishing), Over 45.5 (-110 at time of publishing)

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How to Watch Chiefs vs Bills

  • Date: Sunday, Jan. 21, 2023
  • Time: 6:30 p.m. ET
  • Location: Highmark Stadium (Orchard Park, New York)
  • Network: CBS
About the Author
Victor Araiza

Victor Araiza

Victor Araiza is a sports betting writer for Gaming Today who joined the team in 2022. Araiza has over a decade of experience covering major sports in the United States with a specialty in soccer.

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