2023 College Football Week 4 Odds, Picks, Predictions: How to Bet Notre Dame-Ohio State, Clemson-Florida State

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Last week, no AP Top-25 team faced a then-ranked opponent. Week 3 still delivered, though, with heavy underdog South Carolina giving Georgia a scare (the Bulldogs were down 14-3 at the break), Florida upsetting division rival Tennessee, and Colorado-Colorado State living up to all the hype around Boulder all week long.

On paper, Week 4 looks infinitely more interesting. From Clemson-Florida State at noon to an evening slate including Notre Dame-Ohio State, Washington State-Oregon State, and Penn State-Iowa, Saturday features one high-profile, ranked-vs.-ranked matchup after another. 

We recommend the best college football betting sites in our odds overview for the best games of Week 3. Let’s break down the best College Football Week 3 odds and analyze a few of the best matchups here.

College Football Odds for Week 4

View the table below to find the latest live college football odds. You can search for a specific team to see its odds directly. By clicking on the preferred odds below, you can sign up for the sportsbook and place a wager.

Week 4 College Football Odds for AP Top 25 Teams

The best available odds for home team spreads are listed along with game totals across top sports betting apps.

  • Rutgers at 2 Michigan (, )
  • 4 Florida State at Clemson (, )
  • 16 Oklahoma at Cincinnati (, )
  • 19 Colorado at 10 Oregon (, )
  • 22 UCLA at 11 Utah (, )
  • 15 Ole Miss at 13 Alabama (, )
  • 18 Duke at UConn (, )
  • 20 Miami at Temple (, )
  • UTSA at 23 Tennessee (, )
  • Arkansas at 12 LSU (, )
  • 14 Oregon State at 21 Washington State (, )
  • Charlotte at 25 Florida (, )
  • UAB at 1 Georgia (, )
  • 3 Texas at Baylor (, )
  • 6 Ohio State at 9 Notre Dame (, )
  • 24 Iowa at 7 Penn State (, )
  • 17 North Carolina at Pitt (, )
  • 5 USC at Arizona State (, )
  • California at 8 Washington (, )

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No. 4 Florida State at Clemson

  • Time: Saturday, 12:00 p.m. ET
  • TV/Live Stream: ABC

One of the toughest tests remaining on the schedule for the Seminoles comes this Saturday when they travel to Death Valley. Clemson is currently unranked in the AP poll, but the Tigers have won the ACC seven of the last eight seasons, dating back to 2015. Dabo Swinney’s team is getting as many as 2.5 points at home against a team coming off a surprisingly close road win at Boston College. For Florida State, the biggest question is whether Jordan Travis will be healthy following an injury that briefly sidelined him last Saturday.

Clemson’s defensive line is stout enough to challenge the Florida State offense, but the Seminoles have two players that can break the game open in Johnny Wilson and Keon Coleman. The Tigers are a dangerous home underdog, but if Travis is 100%, Florida State will be able to not only survive but cover 2.5 points (the line at FanDuel as of Tuesday morning).

Pick: Florida State , Under

No. 15 Ole Miss at No. 13 Alabama

  • Time: Saturday, 3:30 p.m. ET
  • TV/Live Stream: CBS

Alabama has still not figured out the quarterback position, which makes the Tide one of the hardest teams in college football to predict right now. Ty Simpson and Tyler Buchner both saw the field in Saturday’s win over South Florida after Jalen Milroe started his team’s first two games, including a loss to Texas in which Milroe was intercepted twice and sacked five times. Going forward, it appears that Buchner — who started against USF and was benched in favor of Simpson — is one of three Alabama quarterbacks we might see under center.

Through three games this season, Ole Miss once again boasts one of the most prolific offenses in the country. Even if you discount the 73-point outburst in the opener against Mercer, the 37-20 win over Tulane in Week 2 and the 48-23 win over Georgia Tech in Week 3 showed how dangerous Jaxson Dart and this offense are. ESPN’s SP+ ranks the Ole Miss offense No. 7 in the country, and given Alabama’s struggles against Texas (and the Longhorns’ offense, No. 15 in SP+), the Rebels should have no trouble moving the ball on the Crimson Tide.

Pick: Over

QB Shedeur Sanders will keep Colorado in it, but the defense will not be able to get enough stops this week.
QB Shedeur Sanders will keep Colorado in it, but the defense will not be able to get enough stops this week vs. Oregon. (AP Photo/David Zalubowski)

No. 19 Colorado at No. 10 Oregon

  • Time: Saturday, 3:30 p.m. ET
  • TV/Live Stream: ABC

Colorado remains unbeaten after surviving an entertaining battle against in-state rival Colorado State last weekend. The Buffs have played some solid opponents so far this season, but haven’t faced a challenge quite like this weekend’s trip to Eugene to take on QB Bo Nix and the Ducks. Undefeated Oregon, coming off a 10-3 season in 2022, has blown out Portland State and Hawaii, but got all it could handle from Texas Tech in Week 2 — the Ducks entered the fourth quarter trailing 27-18 before winning 38-30.

Expect Nix and the Ducks’ home crowd to give Coach Prime and Colorado their first loss of the season. QB Shedeur Sanders will keep his team in it, but a Colorado defense that gave up 42 points to TCU in the opener and 35 to CSU (in double OT) will not be able to get enough stops this week.

Pick: Colorado

No. 22 UCLA at No. 11 Utah

  • Time: 3:30 p.m. ET
  • TV/Live Stream: FOX

Washington, Oregon, Colorado, and USC have all gotten a ton of national love throughout the first month of the season, while UCLA and Utah (particularly the former) have quietly started out 3-0 as well. The Utes opened the season by thumping Florida without starting QB Cam Rising, and they’ve continued to roll since, even as Rising has remained sidelined. Rising, who is recovering from a torn ACL he suffered in the Rose Bowl last year, could return this week, but his status is still unclear.

UCLA has won all three of its games so far by double digits but is yet to face an opponent from a major conference. Utah won last year’s meeting between these teams 42-32 in Los Angeles, and the home team feels like a safe bet to cover in this one, especially if Rising can get on the field.

Pick: Utah

No. 24 Iowa at No. 7 Penn State

  • Time: Saturday, 7:30 p.m. ET
  • TV/Live Stream: CBS

Penn State will have a raucous atmosphere as the backdrop for Saturday’s game against the visiting Hawkeyes. The Nittany Lions are a trendy pick to win the Big 10 thanks to talented QB Drew Allar. The sophomore did not see the field much last season, but many expect him to raise the ceiling for this team, even after an 11-2 season that included a Rose Bowl win. His statistics so far this year have not been spectacular, but the 6-foot-5 signal-caller has already shown enough in limited action that he’s considered a top prospect in the 2025 NFL Draft.

Allar’s Heisman odds are currently . His Heisman odds could change dramatically with a standout performance in primetime against Iowa, which has the top-ranked defense in the country, according to ESPN’s SP+. The Hawkeyes have held each of their first three opponents to 14 points or fewer, which makes the Under a tempting play.

Pick: Under 

No. 6 Ohio State at No. 9 Notre Dame

  • Time: Saturday, 7:30 p.m. ET
  • TV/Live Stream: NBC

If there were a favorite to draw the biggest ratings of any game on Saturday, that would have to be the clash between the Buckeyes and the Irish. Ohio State has as much talent as anyone, including arguably the best wide receiver in the country in Marvin Harrison Jr., who is to win the Heisman. But the OSU offense has not yet lived up to expectations, and it faces a tough defense Saturday night at Notre Dame Stadium.

The 4-0 Irish boast NFL talent on the offensive line and an impressive backfield combo of running back Audric Estime and veteran quarterback Sam Hartman. The latter transferred to South Bend this summer following an impressive run at Wake Forest, and he represents a big upgrade at the position over last year’s starter, Drew Pyne.

For both these teams, Saturday night brings a much tougher challenge than any of their previous opponents. Ohio State’s offense has a higher ceiling than ND’s, but given OSU QB Kyle McCord‘s lack of big-game experience, we recommend taking the Irish and the points in South Bend.


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About the Author
Tyler Everett

Tyler Everett

Tyler Everett has been a sports writer since joining the student newspaper at his alma mater, NC State, back in 2008. He's covered sports and sports business for a number of newspapers and websites, including the Denver Broncos, Charlotte Observer, High Press Soccer, and Sports Business Journal, where he currently works full-time.

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