2023 College Football Week 5 Odds, Picks, Predictions: How to Bet Duke-Notre Dame, Texas-Kansas

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The Week 5 slate of games pales in comparison to last Saturday’s full-day marathon of ranked vs. ranked matchups but still features several interesting games between highly-touted teams. 

From notable SEC clashes like Mississippi vs. LSU to Texas vs. Kansas (both of whom are undefeated) to Duke vs. Notre Dame in primetime on ABC, the final college football Saturday of September 2023 does not lack games worth watching. 

We recommend the best college football betting sites in our overview of the odds for the best games of Week 5. Let’s break down the best College Football Week 5 odds and analyze a few of the best matchups here.

College Football Odds for Week 5

View the table below to find the latest live college football odds. You can search for a specific team to see its odds directly. By clicking on the preferred odds below, you can sign up for the sportsbook and place a wager.


Week 5 College Football Odds for AP Top 25 Teams

The best available odds for home team spreads are listed first, followed by the game totals across top sports betting apps. All the games below, besides Utah vs. Oregon State on Friday night, are scheduled for Saturday.

  • 10 Utah at 19 Oregon State Friday, 9 p.m. ET (, )
  • 6 Penn State at Northwestern (, )
  • 8 USC at Colorado (, )
  • 22 Florida at Kentucky (, )
  • 1 Georgia at Auburn (, )
  • 2 Michigan at Nebraska (, )
  • 24 Kansas at 3 Texas (, )
  • 23 Missouri at Vanderbilt (, )
  • 13 LSU at 20 Mississippi (, )
  • 9 Oregon at Stanford (,
  • Iowa State at 14 Oklahoma (, )
  • 11 Notre Dame at 17 Duke (,
  • South Carolina at 21 Tennessee (, )
  • 12 Alabama at Mississippi State (, )
  • 7 Washington at Arizona (, )
  • Nevada at 25 Fresno State (, )

Week 5 College Football Betting Picks, Analysis

Duke's Riley Leonard (13) carries the ball during the second half of an NCAA college football game against Northwestern in Durham, N.C., Saturday, Sept. 16, 2023. (AP Photo/Ben McKeown)
Duke’s Riley Leonard (13) carries the ball during the second half of an NCAA college football game. (AP Photo/Ben McKeown)

No. 10 Utah at No. 19 Oregon State

  • Time: Friday, 9:00 p.m. ET
  • TV/Live Stream: FS1

Utah has somehow gotten off to a 4-0 start without its starting quarterback from a year ago. At this point, it’s clear this is one of the toughest teams in the country, with or without Cam Rising. Oregon State is also playing well, but the Beavers are coming off a loss to Washington State last Saturday. Utes coach Kyle Whittingham has an experienced roster and a physical defense that will be up to the challenge on the road in Corvallis on Friday night. Expect this one to be close throughout, but it’s hard to pick against Utah right now. 

Pick: Utah moneyline (+140 at time of publishing)

No. 8 USC at Colorado

  • Time: Saturday, 12:00 p.m. ET
  • TV/Live Stream: FOX

Even after Colorado came back down to earth in Eugene last weekend, this is still USC’s toughest test of the year so far. No one has any questions about Heisman contender Caleb Williams (currently to win the award for the second time) and the Trojans offense. The defense, though, still appears to be vulnerable, just as it was a year ago.

While it’s now clear that Colorado has major issues on defense and the offensive line — and the loss of injured CB/WR Travis Hunter has left a huge void — Shedeur Sanders and the Buffs can still move the ball, especially against a shaky defense like USC’s. Sanders should have much more success this Saturday than he did against Oregon last week, but the total in this one won’t quite reach 70-plus.

Pick: Under (73.5 at time of publishing)

No. 22 Florida at Kentucky

  • Time: Saturday, 12:00 p.m. ET
  • TV/Live Stream: ESPN

Kentucky has quietly started the season 4-0, with lopsided wins over Ball State, Eastern Kentucky, Akron, and Vanderbilt. Because of who they’ve played so far, the jury is still out on the Wildcats, but we’ll soon find out whether they’re a contender in the SEC East, as their next four opponents — Florida, Georgia, Missouri, and Tennessee — are all ranked.

The Gators have already had a couple of difficult tests, including a Week 1 trip to Utah and an impressive home win over Tennessee in Week 3. Florida, coming off a closer-than-expected win over Charlotte, is an enticing underdog considering Kentucky’s toughest opponent to date was Vanderbilt.

Pick: Florida (+3 at time of publishing)

No. 24 Kansas at No. 3 Texas

  • Time: Saturday, 3:30 p.m. ET
  • TV/Live Stream: ABC

Texas proved against Alabama that its ceiling is as high as any team in the country. The Longhorns followed their win over the Tide with a close victory against Wyoming, then blew out Baylor in Week 4. If Texas is at its best, they’ll win this game comfortably, but don’t be surprised to see Kansas keep this one close. Jayhawks QB Jalon Daniels is one of the most underrated QBs in college football, and he and RB Devin Neal will keep this one interesting, especially early. Another reason to consider the underdogs is the spot on the schedule: Texas meets Oklahoma in the last Big 12 edition of the Red River Rivalry next weekend.

Pick: Kansas first half (+9.5 at time of publishing)

No. 13 LSU at No. 20 Mississippi

  • Time: Saturday, 6:00 p.m. ET
  • TV/Live Stream: ESPN

LSU has bounced back well after losing to Florida State in the season opener. The Tigers are off to a 2-0 start in the SEC West with a 41-14 win over Mississippi State in Week 3 and a 34-31 home win over Arkansas last Saturday. With QB Jayden Daniels on fire — he’s thrown for six TDs and nearly 700 yards while completing 50-of-63 attempts over the last two weeks — the Tigers feel like a safe bet to get a road win at Ole Miss.

The Rebels’ offense was outstanding through the first three weeks, but Alabama’s physicality created a ton of problems for Mississippi last weekend, and that doesn’t bode well going into a matchup against LSU DTs Maason Smith and Mekhi Wingo. Another reason to doubt Mississippi is the well-documented struggles teams almost always have the week after they play the Tide.

Pick: LSU (-2.5 at time of publishing)

No. 11 Notre Dame at No. 17 Duke

  • Time: Saturday, 7:30 p.m. ET
  • TV/Live Stream: ABC

Notre Dame is coming off an excruciating home loss in primetime to Ohio State. The Notre Dame defense played outstanding against one of the top offenses in the country but gave up the game-winning run in the final seconds on a play when the Irish only had 10 men on the field. Still, ND has to feel good about how much they did right against the Buckeyes, even in an ultimately disappointing loss. 

Duke has been extremely impressive at the start of its second season under coach Mike Elko. Since knocking off Clemson in Week 1, the Blue Devils have routed Lafayette, Northwestern, and UConn, and Saturday night will mark one of the biggest games for Duke football in ages. With ESPN College Gameday in town, Duke will put up a fight against former Wake Forest QB Sam Hartman and Notre Dame.

This one will ultimately be decided up front, where the Irish have the advantage, and that will be enough for a close win on the road. Points will likely be at a premium (just as they were in ND-OSU, a 17-14 game), making the Under the best play.

Pick: Under (50 at time of publishing)

About the Author
Tyler Everett

Tyler Everett

Tyler Everett has been a sports writer since joining the student newspaper at his alma mater, NC State, back in 2008. He's covered sports and sports business for a number of newspapers and websites, including the Denver Broncos, Charlotte Observer, High Press Soccer, and Sports Business Journal, where he currently works full-time.

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