College Football Week 1 Picks & Parlays: 3 Moneyline Predictions is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

For more information, please read How We Rank Sportsbooks, Privacy Policy, or Contact Us with any concerns you may have.

Gaming Today is licensed and regulated to operate in AZ, CO, CT, IN, KS, LA, MI, NJ, NY, PA, TN, and VA.

Last weekend served up a handful of college football games for sports bettors to wet their whistle. But the Week 1 schedule features a full slate of games, giving sports bettors a wide selection of games and betting markets to choose from. The following are some of our favorite college football picks and parlays for Week 1 of the 2022 season.

Bet college football at DraftKings: $50 Free Bet + $1,000 Bonus

Illinois vs. Indiana Betting Lines: Point Spread, Total, Moneyline, Pick

ILL Illinois vs IU Indiana Odds NCAAF Odds

NCAAF · Fri (9/2) @ 8:10pm ET

ILL Illinois at IU Indiana
Memorial Stadium, Bloomington, IN

Our Pick: ILL Illinois at +700. Bet CFB at FanDuel: Bet $5, Get $150 in Free Bets (Win or Lose)

Illinois (5-7 straight up, 7-4-1 against the spread in 2021) got the season off to a strong start last week with a 38-6 win over a poor Wyoming team. QB Tommy DeVito had a respectable but unremarkable outing as the running game thrived. Chase Brown led the way with 151 yards on 19 carries, as the Illini went for 260 yards on the ground.

The defense was just as impressive, holding the Cowboys to 30 yards in the passing game and 1-12 on third downs.

College Football Week 1 parlays & picks feature Illinois, which got off to a strong start last week . (AP Photo/Charles Rex Arbogast)

Indiana (2-10 SU, 2-10 ATS in 2021) was dreadful on offense last season and saw most of its best players depart via the transfer portal. While the team gained a few as well, it’s a rebuilt offense that has a lot of kinks to work out in the season opener.

Army vs. Coastal Carolina Betting Lines: Point Spread, Total, Moneyline, Pick

ARMY Army vs COAS Coastal Carolina Odds NCAAF Odds

NCAAF · Sat (9/3) @ 7:13pm ET

ARMY Army at COAS Coastal Carolina
Brooks Stadium, Conway, SC

Our Pick: ARMY Army at +6000. Bet college football at DraftKings: $50 Free Bet + $1,000 Bonus

What Army (9-4 SU, 6-7 ATS in 2021) does is no secret. The Black Knights are going to run the ball and when you think they might pass, they’ll run the ball again. Why? Because they have an impressive offensive line and a selection of ball carriers (bruisers and speed demons) that most teams would love to have.

Since they control the time of possession, the defense does not need to do much. But Army also has a solid unit on that side of the ball. The pass rush has some NFL potential, and the secondary is not half-bad, either. They’ll undoubtedly make Coastal Carolina (11-2 SU, 6-7 ATS in 2021) QB Grayson McCall work for every yard.

McCall is an excellent quarterback, and he has a solid offensive line to work behind. However, no one other than RB Braydon Bennett caught more than six passes last season. On the defensive side of the ball, the Chanticleers are in good shape on the line but need quite a few guys to step up in the back seven.

North Carolina vs. Appalachian State Betting Lines: Point Spread, Total, Moneyline, Pick

UNC North Carolina vs APPL Appalachian State Odds NCAAF Odds

NCAAF · Sat (9/3) @ 12:00pm ET

UNC North Carolina at APPL Appalachian State
Kidd Brewer Stadium, Boone, NC

Our Pick: APPL Appalachian State at +600. Use Your $1,250 First Bet From Caesars On College Football

Mack Brown is rebuilding his offense this season, but if last week is any indication, the North Carolina (6-7 SU, 5-8 ATS in 2021) offense will be fine in 2022. The offense generated 600+ total yards of offense and scored eight touchdowns in a 56-24 win. But they played a team in Florida A&M they should have destroyed.

Appalachian State (10-4 SU, 8-6 ATS in 2021) has some work to do after losing several players from an excellent defense. But they have talented players coming back, especially in the secondary and at linebacker. The defensive line lacks size and probably relies on a rotation until someone starts to stand out.

On the offensive side of the ball, they have a veteran in QB Chase Brice, who works behind arguably the best offensive line in the Sun Belt. However, the team is short on experience at wide receiver and needs someone to step up.

Parlay No. 1

  • Army (+115), Illinois (+135), and App State (+100) to win (odds via BetMGM)
  • Parlay odds +886

Illinois is a grossly underrated team that appears to have picked up where it left off last season.

Indiana is in a complete rebuild. While the Hoosiers may be the better team once they work the kinks out with all the new parts, they need a couple of games to do so.

Coastal Carolina should be a strong team again, but the same is true for Army. Expect a close game that may depend on whether the Chanticleers can run the ball and keep the Black Knights’ run game off the field.

The North Carolina offense looked great last weekend, but the App State defense is much more formidable. While the defense held Florida A&M to just 56 yards on the ground, the Mountaineers’ offensive line opens holes for the run game.

Parlay No. 2

  • Ohio State at -17.5, Georgia at -17, Arkansas at -6 (spreads and odds via Caesars)
  • Parlay odds +596

If you roll with massive favorites like the Buckeyes and Bulldogs, you might as well combine them into a parlay. Otherwise, you have to risk a lot to win a little. Both teams are expected to contend for playoff spots this season and should be two of the best teams in the country.

The Buckeyes should be able to handle the Fighting Irish and the same for the Bulldogs. While Notre Dame and Oregon have potential, they aren’t on the same level as their opponents.

Cincinnati is in a rebuild, while Arkansas is a team on the rise with a Heisman contender at quarterback.

Also read: CFP National Championship odds | Heisman odds

College Football Betting 101

Before betting on college football, you should feel confident you know what you’re doing and what you’re getting into. If you have any questions, you can find the answers to many common questions on our College Football Odds page.

For additional assistance, the following pages may be of some help:

For additional helpful information, check out our Tools page.

About the Author
Travis Pulver

Travis Pulver

Writer and Contributor
Travis Pulver is a Senior Writer for Gaming Today and a lifelong football fan, something he says comes naturally having been born in the football-crazy state of Texas. Through the years, his love of sports has extended into baseball, basketball, golf, and rugby. Life currently finds him in Indiana with his wife and two kids.

Get connected with us on Social Media