College Football Picks & Parlays for Week 4: Wake Forest a Live Dog vs. Clemson is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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We are three weeks into the 2022 college football season, and it is about to get real. It’s time for conference play to get rolling. Since games start to mean more, chances are good the action will get more intense — and even more fun to bet on. Let’s review some college football picks and parlays for Week 4.

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Clemson vs. Wake Forest Betting Lines: Point Spread, Total, Moneyline, Pick

Clemson is a touchdown favorite in this ACC showdown, per consensus odds on Friday. Here are current numbers from various legal US sportsbooks.

CLEM Clemson vs WAKE Wake Forest Odds NCAAF Odds

NCAAF · Sat (9/24) @ 12:07pm ET

CLEM Clemson at WAKE Wake Forest
Truist Field at Wake Forest, Winston-Salem, NC

Our Pick: WAKE Wake Forest at 7.5 (-109). Bet College Football at DraftKings: Bet $5, Get $200 in Free Bets PLUS $50 Free Bet & $1,000 Bonus

If Wake Forest (3-0 SU, 2-1 ATS) is to end a 13-game losing streak to Clemson, the Demon Deacons will have to bring their ‘A’ game — unlike last season. They can’t turn the ball over (they did that three times last year, and two led to Clemson touchdowns), must run the ball (36 total rushing yards), and the defense has to get a few stops (Clemson scored on five of six drives in the second half).

Oh, and Sam Hartman needs to have a career day against one of the better defenses in the country.

college football picks
Sam Hartman and Wake Forest plus the points figure into our college football Week 4 parlays (AP Photo/Chuck Burton)

As for Clemson (3-0 SU, 1-2 ATS), the Tigers need to continue to play as well as they have been. They are averaging over 41 points/game while giving up only 14. However, they’ve done so against a lackluster Georgia Tech team, a mediocre FCS team, and a struggling Louisiana Tech team.

So, all Clemson has done is beat up on lesser teams, which Wake Forest is not.

Betting Analysis

Clemson’s offense is a little better than last season, but it still isn’t good. Expectations remain high for DJ Uiagalelei because of how he played in a spot start against Notre Dame in 2020, but it is time to face facts. He’s just okay; good enough to beat lesser opponents. Otherwise, he needs a lot of help from the defense, which is pretty good.

The Tigers defense will keep Clemson in the game and could even lead the team to a win. But Wake Forest will do a better job of protecting the ball this year, and Sam Hartman will lead Wake Forest to a rare victory over Clemson, or at least keep it close.

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Duke vs. Kansas Betting Lines: Point Spread, Total, Moneyline, Pick

Similar point spread here, with Kansas laying a touchdown at home to Duke.

DUKE Duke vs KANS Kansas Odds NCAAF Odds

NCAAF · Sat (9/24) @ 12:00pm ET

DUKE Duke at KANS Kansas
David Booth Kansas Memorial Stadium, Lawrence, KS

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No, it’s not a typo. Kansas (3-0 SU, 3-0 ATS) is undefeated three weeks into the season, something that has not happened since 2009 (the Jayhawks went on to finish 5-7). They even received votes in the AP Poll! How in the world did this happen? Well, it helps when you have the No. 5 scoring offense in the country and average 51 points/game.

Again, not a typo.

They did run up 56 points on an FCS team, but they followed that up with 55 against West Virginia and then 48 against a good Houston team. Most of the damage comes in the run game, but the team has been getting enough out of the passing game to keep opposing defenses honest.

As for Duke (3-0 SU, 2-1 ATS), the offense has not been nearly as explosive as the Kansas offense. But it has been efficient, scoring 30+ points against their two FBS opponents (Temple and Northwestern) and 49 last week against an FCS team (N.C. AT&T). They have outscored their opponents 110-43 (with one shutout).

Betting Analysis

The Duke defense will give the Kansas offense more of a challenge than the Jayhawks have seen this year, but it will not slow them down for long. Will it be explosive enough to win by more than a touchdown? That’s a good question. But don’t expect much from the Blue Devils offense.

Our Pick: Under 65.5

Bookmark theseDiscover the best sportsbook app for you | How to bet on CFB

Florida vs. Tennessee Betting Lines: Point Spread, Total, Moneyline, Pick

The Volunteers are laying double-digits in this spot against the Gators, according to oddsboards on Friday.

UFL Florida vs TENN Tennessee Odds NCAAF Odds

NCAAF · Sat (9/24) @ 3:30pm ET

UFL Florida at TENN Tennessee
Neyland Stadium, Knoxville, TN

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Florida (2-1 SU, 1-2 ATS) got the season off to a strong start with an upset win over then-No. 7 Utah. Quarterback Anthony Richardson looked like he had Heisman potential. The defense stepped up and made plays, and it looked like the Gators were ready to contend inside the SEC once again.

But then they lost to Kentucky and barely held on to beat a poor South Florida squad. Richardson has struggled to throw the ball since the Utah game, completing just 40% of his passes against Kentucky and just 55.6% against USF. He has yet to throw a touchdown pass and has thrown four interceptions.

After rushing for 134 yards and three touchdowns against Utah, Richardson has gained just 28 yards on the ground.

On the other hand, Tennessee (3-0 SU, 3-0 ATS) has been one of the most explosive teams in the country. They have the No. 3 scoring offense, are No. 3 in total offense, and No. 5 in passing offense. Their lofty stats benefited from playing a pair of mediocre MAC teams.

Betting Analysis

The Gators have been a disappointment since upsetting Utah in Week 1. Should Florida fall behind, it is not able to catch up. On defense, the Gators are good enough to slow down Tennessee for maybe a half. But they’ll be tired in the second half when the Vols blow them out.

College Football Week 4 Parlay No. 1

Based on the picks above, this parlay will contain the following legs (odds via BetRivers):

  • Wake Forest +8 -113
  • Duke-Kansas: Under 65.5 -110
  • Tennessee -10.5 -107
  • Parlay Odds +596

If you are not confident Tennessee can win ATS, go with the total Under 62.5 (-107); parlay odds will remain the same. A $100 bet on this parlay will result in a $696 payout, your stake plus $596 in winnings.

How Much Can You Win? Use Our Parlay Calculator To Find Out!

College Football Week 4 Parlay No. 2

For this parlay, let’s use the picks made by our writers for the following games. Since the odds will come from BetMGM for the parlay, the odds listed here may not match what the writers list in the articles:

Bet $100 on this parlay; if it wins, you’ll get a $695 payout, your stake, and $595 in winnings.

College Football Week 4 Parlay No. 3

  • Bowling Green-Mississippi State: Over 52.5 -110
  • Alabama-Vanderbilt: First half total Over 33.5 -115
  • Minnesota-Michigan State: Mohamed Ibrahim Over 127.5 yards -115
  • Texas A&M-Arkansas: First half total Under 24 -110
  • Parlay Odds: +1173 *Odds via DraftKings

Mississippi State will be looking to get the offense on track after a lackluster showing against LSU, and it should do just that against Bowling Green’s defense. The Bulldogs will not go over the total independently, but they’ll get enough help from the Falcons.

Vanderbilt has been surprisingly competitive (sort of), but they haven’t faced a team like Alabama. It’s always hard to recommend a team cover a 40.5-point spread; in this case, it is hard to say whether the total will be over 59 points. Alabama could cover that on its own. But once Nick Saban starts working guys in during the second half, their offense will not score as much.

But with the ‘A’ team in for the first half, it would not be shocking to see Alabama put up 33.5+ points (or get enough help from Vanderbilt to do so).

Expecting a running back to gain over 127.5 yards is asking a lot. But he has gone for 130, 132, and 202 this season. While the secondary is where the Michigan State defense is weakest, the Gophers will feed Mohammed Ibrahim the ball. The Spartan defense is allowing less than 90 yards a game so far this season, but that is because teams are too busy passing on them.

The Arkansas offense has been solid this year, but it hasn’t faced a defense as stout as Texas A&M’s. As for the Aggies, the offense has been atrocious, and it is hard to say if it will be better with a new quarterback behind center. This will be a low-scoring affair.

Also readCFP National Championship odds | Heisman odds

College Football Betting 101

Before betting on college football, you should feel confident you know what you’re doing and what you’re getting into. If you have any questions, you can find the answers to many common questions on our College Football Odds page.

For additional assistance, the following pages may be of some help:

For additional helpful information, check out our Tools page.

Also readHeisman odds | CFP National Championship odds | Georgia Tech vs. UCF Odds & Pick

About the Author
Travis Pulver

Travis Pulver

Writer and Contributor
Travis Pulver is a Senior Writer for Gaming Today and a lifelong football fan, something he says comes naturally having been born in the football-crazy state of Texas. Through the years, his love of sports has extended into baseball, basketball, golf, and rugby. Life currently finds him in Indiana with his wife and two kids.

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