College Football Week 1 Odds: Buckeyes, Irish, Bulldogs Featured In Early Showcases is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. Gaming Today may receive referral compensation from the sportsbook company when you claim a bonus offer or promotion through a link on this site. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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C.J. Stroud and Ohio State are big favorites vs. Notre Dame, per early Week 1 college football odds (AP Photo/Jay LaPrete, File)

It’s never too early to talk — or even wager on — football, and bettors can start by taking in odds for Week 1 of the 2022 college football season. The early portion of the season showcases several major programs, including Ohio State, Notre Dame, and LSU.

Opening lines are up at William Hill (rebranded Caesars Sportsbook in most of the country) in Vegas and will soon be available to bettors through mobile sportsbook apps. Notre Dame at Ohio State, and then Oregon vs. Georgia at Mercedes-Benz Stadium in Atlanta, kick off on September 3. Florida State vs. LSU is September 4 at Caesars Superdome in New Orleans.

Before placing any wagers, bettors are encouraged to familiarize themselves with the best sportsbook bonuses available. New bettors will be entitled to welcome bonuses and promotions at most leading sportsbooks. Meanwhile, existing customers will find sports-specific promotions, including those offered at the beginning of college football season.

2022 College Football Week 1 Odds

Notre Dame vs Ohio State Odds NCAAF Odds

NCAAF · Sat (9/3) @ 12:00 pm ET

Notre Dame at Ohio State
Ohio Stadium, Columbus, OH

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Notre Dame vs. Ohio State

Marcus Freeman, 36, is squarely in the spotlight as he transitions from Notre Dame defensive coordinator to head coach. Freeman replaces Brian Kelly, who departed for LSU.

The Fighting Irish take on a different personality — at least internally. Kelly led the program for 12 years, though, so it will take some time before Freeman’s fingerprints are apparent.

Ohio State is led by sophomore sensation C.J. Stroud. The Buckeyes’ signal-caller is the preseason favorite at DraftKings and FanDuel to win the Heisman Trophy. Sophomore wide receiver Jaxon Smith-Njigba is primed to cement himself as the next great Buckeye pass-catcher.

Oregon vs Georgia Odds NCAAF Odds

NCAAF · Sat (9/3) @ 3:00 pm ET

Oregon at Georgia
Mercedes-Benz Stadium, Atlanta, GA

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Oregon vs. Georgia

Oregon appears to be heading into a buzzsaw to open its 2022 campaign. New head coach Dan Lanning most recently served as Georgia’s defensive coordinator.

Georgia has plenty of reloading to do around a roster that is sending a number of players to the NFL. Regularly securing top-3 recruiting classes makes that task more manageable. The Bulldogs feature talent all over the field, and tight end Brock Bowers is someone to watch in particular. As a freshman in 2021, Bowers finished with a 56-882-13 line, and is another future NFL prospect.

Florida State vs LSU Odds NCAAF Odds

NCAAF · Sun (9/4) @ 8:00 pm ET

Florida State at LSU
Caesars Superdome, New Orleans, LA

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Florida State vs. LSU

Though this matchup is technically at a neutral venue, it’s reasonable to expect a pro-Cajun crowd. The Tigers are a combined 11-12 since going undefeated en route to the 2019 National Championship. The LSU faithful will be particularly amped for the full Brian Kelly experience. The Bayou Bengals’ new head coach is tasked with raising the program back to a lofty perch.

Florida State head coach Mike Norvell enters his third season at the helm of the Seminoles’ program. He’s 8-13 overall, but oversaw modest strides in 2021. He’s secured three top-25 recruiting classes since arriving in Tallahassee. However, there’s plenty of work remaining to rehabilitate this former college football power.

About the Author
Craig Williams

Craig Williams

Craig Williams is a Charlotte-based writer for Gaming Today, who has worked professionally in the gaming, fantasy sports, and sports business industries. He’s an avid fantasy football player, managing over 100 leagues across multiple formats. When he’s not pouring over Vegas odds and statistics, he’s indulging in soccer and enjoys anything from LigaMX to Champions League.

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