Giants vs. Bills Odds, Props & Predictions: NY Huge Road Dogs Against Buffalo in NFL Week 6 SNF is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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NFL Week 6 kicked off with an exciting Chiefs-Broncos Thursday night matchup. Was it because Taylor Swift was in the Kingdom? At any rate, it’s now time to look ahead to the Sunday Night Football battle between the New York Giants and the Buffalo Bills

Here are the best available NFL odds for the moneyline, spread, and total across the best sports betting apps for Week 6.


The Giants enter this game 0-5 against the spread (ATS) on the season, while the Bills are 3-2 in that same category. Buffalo also boasts a 3-2 straight-up (SU) record while New York has gone 1-4. 

Now New York travels to Buffalo as it attempts to get win No. 2 in this young season. Can the G-Men upset the Bills and get the victory as 14.5-point underdogs, or can they at least cover? 

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Giants vs. Bills Odds: Spread, Moneyline, Total

Here are the odds for Giants vs Bills at the time of publication. Current odds will be listed in the table following and designated sportsbook where available. Learn more about sportsbook promos when signing up to receive bonus bets.

Spread: Bills -14.5 (+108), Giants +14.5 (-112)
Moneyline: Bills -1200, Giants +750
Over/Under: 44.5 points scored by both teams combined


How to Watch Giants vs. Bills

Date: Sunday, Oct. 15, 2023
Time: 8:20 p.m. ET
Location: Highmark Stadium – Orchard Park, NY
Network: NBC

Also read: NFL Week 6 odds | Super Bowl odds | NFL MVP odds | NFL betting promos

Giants vs. Bills Props

View live player props on anytime touchdowns and quarterback passing. Click on the odds you like to place your bet at the designated sports betting app.


Check out other spotlight prop markets at DraftKings, FanDuel, and BetMGM below. Odds are subject to change.

1st Buffalo Bills Drive Result (DraftKings)

Touchdown: +155
Punt: +175
Field Goal attempt: +340
Turnover, Turnover on downs or safety: +600

1st NY Giants Drive Result (DraftKings)

Touchdown: -170
Punt: +425
Field Goal attempt: +500
Turnover, Turnover on downs or safety: +550

Second Half Total (FanDuel)

Over 21.5: -105
Under 21.5: -115

Second Half Spread (FanDuel)

Giants +6.5: +100
Bills -6.5: -120

Quarterback Prop (BetMGM)

Josh Allen
Over 264.5: -115
Under 264.5: -115

Rushing Props (BetMGM)

James Cook
Over 57.5: -110
Under 57.5: -120

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Giants vs. Bills Analysis and Predictions

The going’s been tough for the Giants so far in 2023. They only have one tally in the win column, quarterback Daniel Jones has been sacked 28 times, and their defense ranks in the bottom third of the league. They also rank next-to-last on offense in points scored per game and they rack up an average of 6.6 penalties each contest. 

The Bills’ season, on the other hand, has been much more promising. Yes, they dropped their Week 1 contest 22-16 to the Jets and then lost their Week 5 battle 25-20 to the Jaguars in London. But the Bills, unlike the Giants, aren’t suffering quarterback woes. Quite the opposite, as a matter of fact. 

Buffalo signal-caller Josh Allen has only been sacked nine times, and he’s passed for 1,407 yards and 11 touchdowns. The Bills have the third-best scoring offense in the NFL and the fifth-best overall defense. But even with this early success, BetMGM’s John Ewing reports that the Bills season win total recently dropped from 11.5 to 10.5. 

So will Buffalo end up getting loss No. 3 in Week 6?

Not likely.

When it comes to the spread, though, if you’re thinking that 14.5 points is a big number, you might be onto something. Buffalo hasn’t covered in three of its last four matchups. And if you’re eyeing the Over/Under, remember that the Bills’ games have exceeded the Over twice this season.

When it comes to straight-up wins, when these two squads square off, NYG has won three of the last five. So with all this in mind, there are a few spots we actually like in this Sunday Night showdown on NBC. 

We’re going with the Over of 44.5 points scored by both teams combined. It’s true; Buffalo has only hit the Over twice this season and the Giants once. But Josh Allen and his offense will likely get out to a fast start as they try to get right after their loss across the pond. 

We also like the Giants to cover. It could happen in garbage time or Brian Daboll & Co. might surprise us all and make it a competitive 60 minutes. Either way, 14.5 points is pretty hefty.

And for a player prop – because why not – let’s ride James Cook’s Over rushing yards.


• Over 44.5 points scored by both teams combined (Live: )
• Giants +14.5 (Live: )
• James Cook Over 57.5 rushing yards (Live: )

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About the Author
Erica Renee Davis

Erica Renee Davis

Erica Renee Davis is a sports betting writer with Gaming Today. She graduated from the University of Georgia with degrees in journalism and political science. After cheering as an NFL cheerleader for the Atlanta Falcons, Erica moved to Los Angeles where she became the host of Kevin Pollak's This Week In Football digital show. Since then, she has appeared as an on-air host and sports commentator for FOX Bet, Spectrum News 1 SoCal, CNN, HLN, and TEGNA's Daily Blast Live. Erica is a die-hard Georgia Dawg and a hopelessly devoted Clippers fan.

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