Rams vs. 49ers Odds & Prediction: Can Los Angeles Buck Recent Trends on MNF?

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The LA Rams face the San Francisco 49ers on Monday Night Football in the final Week 4 game of the 2022 NFL season.

Rams vs. 49ers odds opened with San Francisco as a 1-point favorite. The 49ers were -1.5 at DraftKings, FanDuel, BetMGM, and PointsBet as of Monday morning. The total was 42.5. Four of the last five games between these two teams have gone Under.

Let’s take a look at the latest MNF odds as well as our Rams vs. 49ers prediction.

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MNF Odds: Point Spread, Moneyline, Total

Here are Monday Night Football odds from around the sports betting marketplace, as the 49ers look to continue their home dominance against the Rams.

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San Francisco Has Owned the Rams at Home

San Francisco will look to win its fourth consecutive game against LA at Levi’s Stadium on MNF. The last time the Rams visited San Francisco, in Week 10 of the 2021 season and also on a Monday night, they suffered their most lopsided loss of the season, 31-10, as a 3.5-point favorite. That also was the biggest rout of the season for the 49ers and QB Jimmy Garoppolo.

Over the previous three years, the 49ers have paid off handsomely for their backers at sportsbooks when facing the Rams, winning six of seven overall meetings with five of the victories coming as an underdog.

The lone loss during that dominant stretch came in last season’s NFC title game at SoFi Stadium. San Francisco squandered a 10-point lead in the fourth quarter and lost, 20-17. But still, the 49ers were 7-0 against the spread (ATS) during that span.

This season, San Francisco (1-2) has been upset at Chicago and Denver. The 49ers did get star TE George Kittle back from a groin injury last week against the Broncos. But canceling out that terrific news was the loss of OLT Trent Williams, a first-team All-Pro in 2021, who suffered a high ankle sprain vs. Denver. He’ll be out for at least four weeks.

Also read: MNF Player Props & TD Scorer Bets

Stepping up in to replace Williams likely will be Colton McKivitz, a fifth-round draft choice in 2020 with just four career starts.

For LA, outside of the connection between QB Matthew Stafford and WR Cooper Kupp, who leads the league with 28 catches, the offense has been relatively mediocre.

Los Angeles Rams quarterback Matthew Stafford (AP Photo/Rick Scuteri)

For the second straight year, Stafford is tied atop the passer chart in interceptions (five), and the running game is generating an average of 3.4 yards a carry, tied for fourth worst. And that’s with RB Cam Akers back after his 2021 Achilles injury.

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Analysis: The 49ers will be counting on Garoppolo, making his second start of the season in place of injured Trey Lance, to step up his production after a lackluster season debut in Denver. He was 18-for-29 and averaged only 5.4 yards per pass play. His performance did come against the league’s third-ranked defense in hostile territory.

LA’s defensive unit is ranked 17th. But that’s the same ranking the Rams had during their Super Bowl season a year ago. But can the 49ers thrive without their top OLT? Not to mention they are already missing their top RB, Elijah Mitchell, who’s been on IR since a Week 1 knee injury.

As for the Rams (2-1), their 20-12 victory over Arizona put them in sole possession of the NFC West lead. LA held the Cardinals without a touchdown, but the Rams defense had difficulty getting off the field.

The Cardinals had drives of 16, 17, and 19 yards in the second half before settling for FGs while running a total of 81 plays to the Rams’ 45. That 36-snap gap was the second biggest in a game this season.

Anyway, what’s likely to bend Monday’s game in the Rams’ favor is San Francisco’s big loss on the offensive line. With Rams standout DT Aaron Donald sure to get gobs of extra attention from the 49ers’ line, that could leave Williams’ backup vulnerable in trying to protect Jimmy G’s blind side.

Last week marked the first time Garoppolo started taking reps with the starters since last season. He reportedly wasn’t even given a playbook this summer while the team looked to unload him, his injured shoulder, and his contract.

One more thing regarding Garoppolo. Maybe it would be wise for the 49ers to fit him with the equivalent of curb feelers, so he doesn’t drift out of the back of the end zone again when dropping back to pass.

In summary, the Stafford-Kupp combo should give the Rams an edge. Sure, the 49ers have one of the league’s best front sevens, but the same can’t be said for the secondary. And last year, Kupp caught 29 of 34 throws his way vs. SF (85.3 percent). Stafford is still the second-most accurate passer in the league despite his proclivity to throw picks.

Lastly, here’s this: The score has gone Under in 30 of 48 league games through Week 3, including five of six played by the Rams and 49ers.

Forecast: Rams 23, 49ers 14

Bookmark this: Discover the best NFL betting app for you | Super Bowl 57 odds

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, has been a gaming writer (primarily the NFL) for almost four decades, with his work appearing in publications/websites across North America. He's a big fan of the Arkansas Razorbacks, Philadelphia's Eagles and Phillies, and inexplicably the NHL's Winnipeg Jets.

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