Mexico vs. USMNT Betting Odds: CONCACAF World Cup Qualifying Heads To Estadio Azteca is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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Mexico is favored on oddsboards to claim three points against the USMNT in Thursday's World Cup Qualifier (AP Photo/Julio Cortez)

The final window of CONCACAF World Cup 2022 qualifying kicks off Thursday, highlighted by the region’s fiercest rivalry. Mexico vs. United States has delivered a number of memorable moments over the past few decades, with another chapter set to be written at Estadio Azteca in Mexico City. Mexico vs. USMNT betting odds take home-field advantage, team selection, and group positioning into account ahead of Thursday’s clash.

Both Mexico and the USMNT are in World Cup qualifying position with 21 points apiece, tied for second place behind Canada. Panama lurks in fourth with 17 points. After facing the Stars & Stripes, Mexico travels to Honduras and hosts El Salvador in Games 2 and 3 of this qualifying window (March 27 and 30). Meanwhile, the United States hosts Panama in a pivotal tie and travels to Costa Rica to conclude the final round of qualifying.  The top three teams in the CONCACAF standings qualify for the World Cup, while the fourth-place team advances to an international playoff.

Bettors can find odds at multiple sportsbooks, including DraftKings, FanDuel, and BetMGM.

Mexico vs. USMNT Betting Odds And Preview

Mexico Win+105+110+110
USMNT Win+245+250+260

The USMNT’s 1-1 draw during 2018 World Cup qualifying is their most recent result on Mexican soil. Christian Pulisic, Kellyn Acosta, and DeAndre Yedlin each played in that match. The trio’s guidance will be paramount if the USMNT is going to steal a point or pull the upset outright.

Both teams will be without key names. The European Cups have taken a bite out of the USMNT roster. Midfielder Weston McKennie broke his foot in Champions’ League play for Juventus, and Barcelona fullback Sergino Dest suffered a hamstring injury in Europa League action.

Meanwhile, Mexico will be without forward Rogelio Funes Mori, midfielder Andres Guardado, and defender Julio Cesar Dominguez.

The USMNT’s depth — and personality — will be tested, and there are several names to keep in mind. Acosta provides versatility and “glue” to coach Gregg Berhalter’s arsenal. Forwards Jordan Pefok, and Ricardo Pepi provide a centralized presence capable of mixing it up for a scrappy goal in the box. And, finally, Gio Reyna logged a full 90 at the weekend in Bundesliga play. He’s one of the USMNT’s stars and someone who can make something out of nothing.

Midfielder Diego Lainez is a spark plug for Mexico. He’ll get forward and pose problems in the final third with his quickness and creativity. Lainez hasn’t played extensively at club level (Real Betis, La Liga), but even as a sub, he’s a significant threat. Especially if the USMNT is playing with heavy legs in the second half.

There’s chatter the USMNT should prioritize its matchup with Panama. Don’t be fooled. This is a rivalry match, and Mexico will come out with bite and venom. They’ve lost three straight to the U.S., and they’re not going to give up a fourth without a fight.

About the Author

Craig Williams

Craig Williams is a Charlotte-based sportswriter who has worked professionally in the gaming, fantasy, and sports business industries. He’s an avid fantasy football player, managing over 100 leagues across multiple formats. When he’s not pouring over Vegas odds and statistics, he’s indulging in soccer and enjoys anything from LigaMX to Champions League.

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