49ers vs. Panthers Odds & Prediction: Can Mismatch on Paper be Competitive?

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The San Francisco 49ers are scheduled to play a late Sunday afternoon road game against the Carolina Panthers in Week 5 of the 2022 NFL season.

49ers vs. Panthers betting odds opened last week with San Francisco as a 3.5-point favorite. The line has since climbed to 49ers -6.5 at DraftKings, FanDuel, BetMGM, and PointsBet.

Let’s take a look at the latest odds as well as our 49ers vs. Panthers prediction.

Updated Point Spread, Moneyline, Total

Here are 49ers vs. Panthers odds from around the sports betting marketplace as of Friday, Oct. 7.

SF 49ers vs CAR Panthers Odds NFL Odds

NFL · Sun (10/9) @ 4:05pm ET

SF 49ers at CAR Panthers
Bank of America Stadium, Charlotte, North Carolina

Bet 49ers vs. Panthers at DraftKings: Up to $1,250 Bonus

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Two Teams Going in Different Directions

It now appears San Francisco is the team to reckon with in the NFC West after its  thumping of the visiting LA Rams on Monday night, 24-9.

And it appears Carolina is the team to defeat in the NFC South after its 26-16 home loss to struggling Arizona dropped the Panthers and QB Baker Mayfield to 1-3.

The 49ers, though, get this week’s scheduling atomic wedgy by having to travel to the East Coast across three time zones on short rest. No other team has to do that this year. At least it’s not in the early Sunday slot.

The scenario is almost identical to what the 49ers experienced in Week 11 last season when they came off a decisive home win vs. the archenemy Rams on a Monday night and then had to travel to Jacksonville on short rest.

The 49ers beat the Jaguars 30-10 in the early Sunday time slot as a 6.5-point choice. Similarly, Las Vegas had success in Pittsburgh after a Monday night home game, winning  26-17 in Week 2 of 2021.

Overall, teams that travel across three time zones East the past two seasons have gone 17-5 straight up (SU) and 16-6 against the spread (ATS).

San Francisco 49ers wide receiver Deebo Samuel (AP Photo/Jed Jacobsohn)

The 49ers also will play back East next week vs. Atlanta. San Francisco is used to that, too. It opened last season with back-to-backs in Detroit and Philadelphia. The 49ers won both games.

Carolina has been largely inept offensively, with the exception of when Christian McCaffrey is given the chance to run. He’s twice surpassed 100 yards in a game. As for Mayfield, who was booed by the home crowd last week, he’s the 30th-ranked passer in a 32-team league and 31st in completion percentage at 54.7. Trying to look on the bright side, he’s 27th in yards per throw at 6.4.

If fellow QBs Sam Darnold and rookie Matt Corral weren’t on IR, Mayfield probably would be watching games next to coach Matt Rhule, whose team hasn’t made Carolina backers at the sportsbooks happy by going 3-15 ATS since Week 4 last year.

One more thing: Through four weeks of the season, there have been six games with an over/under number less than 40. San Francisco was involved with two of them, going under in both.

Analysis: The 49ers have been especially dominant defensively, yielding a league-low 11.5 points a game and allowing the second fewest yards per game. That’s bad news for a Carolina offense that’s struggled versus middle-of-the-pack defenses for four weeks.

On Monday, San Francisco spent most of the evening harassing Rams QB Matthew Stafford, sacking him seven times and holding the defending Super Bowl champs without a touchdown.

On offense, WR Deebo Samuel and RB Justin Wilson showed exceptional bursts of speed in scoring TDs against a Rams defense that rates better than Carolina’s.

But there is concern along the offense line, with the team reduced to using a third-stringer at OLT until star Trent Williams returns from his high ankle sprain.

Forecast: 49ers 27, Panthers 10

Also read: NFL Week 5 betting picks and predictions | NFL Week 5 player props and anytime TD scorer bets

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, is a sports betting writer at Gaming Today. He has been a gaming writer (primarily for the NFL) for more than four decades, with his work appearing in publications and websites across North America. Christ is a big fan of the Arkansas Razorbacks, Philadelphia Eagles and Phillies, and the NHL's Winnipeg Jets.

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