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Tom Brady's Bucs are favored over Patrick Mahomes' Chiefs in Week 10, per early odds offered on the 2022 NFL season (AP Photo/David J. Phillip)

The NFL had been teasing fans leading up to its 2022 schedule release by announcing a handful of games, but the league let it drop Thursday night by unveiling the entire slate. Even though the season is still months away, sportsbooks have opened betting on several games. Week 1 odds are posted throughout the market, and DraftKings offers point spreads and totals through Week 17.

Let’s look at the betting lines for some of the games that are likely to garner a little more interest than others. We’ve already covered some of the pivotal Week 1 matchups, the international games, the first Thursday Night Football game on Prime Video, and the Christmas Day slate.

This post will focus on games not previously featured.

Dolphins vs. Patriots, Week 1

The Dolphins are tired of falling short of the playoffs, so they upgraded several parts of the roster during the offseason. They traded for one of the best wide receivers in the game, Tyreek Hill, beefed up the offensive line, added a complementary receiver (Cedrick Wilson from the Cowboys), and signed a pair of running backs (Sony Michel and Chase Edmonds).

Mac Jones would love to start the season off with a win over the Dolphins after losing to Miami twice last season. Despite having a solid debut in Week 1, the Patriots lost a close one to the Dolphins, 17-16. Jones and the Patriots also ended up losing their regular-season finale to the Fins (33-24).

Browns vs. Panthers, Week 1

Cle. Browns vs Car. Panthers Odds NFL Odds

NFL · Sun (9/11) @ 1:00 pm ET

Cle. Browns at Car. Panthers
Bank of America Stadium, Charlotte, NC

Visit DraftKings and get a $50 free bet with $5 deposit + a 20% deposit match bonus up to $1,000

If Deshaun Watson does not get suspended, Browns fans will get a taste of their new $230 million quarterback. Will he be the guy they think he is? Will there be rust from such a long layoff (he last played in 2020)?

Because of Watson’s uncertain status, this Week 1 contest is the only Browns game DraftKings hung a line on.

Carolina, meanwhile, is among the rumored destinations for Baker Mayfield, and should he end up with the Panthers, the drama around this game will intensify.

Cardinals vs. Raiders, Week 2


There will be no excuses for Derek Carr and the Raiders in 2022. They have an offensive-minded head coach in Josh McDaniels and a great new weapon for Carr in former Green Bay wide receiver Davante Adams. But will they have the kinks worked out in the new offense by Week 2?

Arizona has gotten off to a strong start the last two seasons with wins over the 49ers in 2020 and the Chiefs last season. It may be a little harder to get off to a hot start without DeAndre Hopkins in the lineup, but the passing game should be fine with Marquise Brown and A.J. Green.

Bengals at Cowboys, Week 2

Cincinnati will be dying to prove its Super Bowl appearance was not a fluke. What better way to do that than to beat America’s Team on its own field? An offensive line beefed up in free agency should give Joe Burrow better protection in 2022, but the key may be the running lanes it opens for Joe Mixon.

The Cowboys have won their home opener for the last five years and would love to make it six in a row. Whether they can may depend on whether Dan Quinn’s defense can pick up where it left off.

Titans vs. Bills, Week 2

Tennessee’s Week 6 win over the Buffalo Bills was one of the best games of the 2021 regular season. That win got the Titans into Super Bowl conversations last year. The Titans should have Derrick Henry back, and while they lost A. J. Brown, they picked up a promising rookie in the draft in Treylon Burks.

But the key to a Tennessee upset will be slowing the Buffalo offense.

Chiefs vs. Bucs, Week 4

There’s nothing like a Super Bowl rematch to spice up the early action. Kansas City was favored heading into Super Bowl 55, but the Buccaneers dominated the game and won easily. This time, the Chiefs will be down Tyreek Hill and several other players on both sides of the ball from last year’s team.

But the Bucs are not without losses of their own, namely head coach Bruce Arians. The team did not have to go far for a new head coach, tabbing defensive coordinator Todd Bowles for the job. The most significant offseason news for the Bucs has been the retirement and un-retirement of Tom Brady.

Cowboys vs. Packers, Week 10

This game holds special significance for Cowboys head coach Mike McCarthy. It will be the first time McCarthy will face his former team and QB Aaron Rodgers. The drama that unfolded between them will likely dominate the conversation leading up to the game.

More importantly, by the time this game rolls around in Week 10, both teams will be looking at creating some separation within their division and the rest of the conference. A win, especially one over a quality opponent, will go a long way towards establishing the winner as a Super Bowl 57 contender.

Also read: NFL season win totals 

About the Author
Travis Pulver

Travis Pulver

Senior Writer
Travis Pulver is a senior writer for Gaming Today and a lifelong football fan, something he says comes naturally having been born in the football-crazy state of Texas. Through the years, Pulver's love of sports has extended into baseball, basketball, golf, and rugby. Life currently finds him in Indiana with his wife and two kids.

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