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The Colts and Broncos got Week 5 of the 2022 NFL season off to a sluggish start in a dreadful game on Thursday night. While it is too late to bet the under on that game, there is a full slate of NFL action on deck. Sportsbooks will have a wide range of markets available for Sunday’s games, many of which bettors can combine to form NFL parlay bets.

Combine the right bets, and you stand to win more than if you had made individual wagers, but the risk grows along with the reward. For those interested and willing to take on the risk, here are three of our favorite NFL parlay picks for Week 5, including a couple of same-game parlay bets.

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NFL Parlay Picks: Week 5

You can go with multiple legs if you want to; the more legs, the more you stand to win. But for this parlay (and the rest in this article), we’ll keep them relatively short. Yes, winning more money is great. But the opportunity to win more does not trump how unpleasant losing money can be.

Let’s go over a few options:

Parlay No. 1: 49ers vs. Panthers (odds via PointsBet)

  • Under 40 (-110)
  • 49ers -6.5 (-107)
  • Parlay Odds +260

With the defense leading the way, the 49ers have established themselves as the team to beat in the NFC West. In time, the offense could become more productive as Jimmy Garoppolo gets more comfortable in the offense. The offense will not need to put up big numbers with how well their defense is playing.

San Francisco 49ers quarterback Jimmy Garoppolo is featured in our NFL parlay picks: three NFL plays for Week 5. (AP Photo/Jed Jacobsohn)

As for the Panthers, their offense ranks last in the NFL in total yards (262.3 per game); San Francisco’s defense ranks first in yards allowed (234.5 per game). It will not be shocking if the 49ers D pitches a shutout.

A $100 bet will result in a $360 payday, your stake plus $260 in winnings.

Also Read: 49ers vs. Panthers  | Week 5 Player Props/Anytime TD Scorers | MNF: Raiders vs. Chiefs

Parlay No. 2: Cowboys vs. Rams (odds via DraftKings)

  • Under 43.5 (-110)
  • Cooper Rush passing yards: Under 224.5 (+115)
  • Parlay Odds: +210

Cooper Rush is doing enough on offense for the ‘Boys to win the last three games, but he is not doing much (235, 215, and 223 yards passing in his three starts). There is no reason to think the Cowboys will try to have him do more against the Rams defense.

As for the total, the Rams offense has been underperforming all season, and it is unlikely they will break out against the Dallas D. The Rams defense has not been the dominant unit fans know and love. Still, the ceiling for the Cowboys offense appears to be in the low 20s.

If you feel like tacking on an additional leg, consider this one:

  • Matthew Stafford passing yards: Under 254.5 (+100)
  • New Parlay odds: +360 ( a $100 bet wins $360 resulting in a $460 payday)

Dallas has yet to allow a quarterback to throw for 200 yards; Stafford is averaging 253.75 yards per game this season.

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Parlay No. 3: Player Props Parlay (odds via DraftKings)

  • Justin Fields: Under .5 passing touchdowns (+135)
  • Saquon Barkley: Over 81.5 rushing yards (-115)
  • Cooper Kupp: Over 8.5 receptions (+100)

Justin Fields has two passing touchdowns to his name after four games; the Vikings have allowed three. Minnesota’s pass defense is not great, but the Bears offense averages just 97.5 yards per game after four weeks. A peewee football team might be able to stop Fields from throwing a touchdown.

Barkley is experiencing a career resurgence this year. After blowing up for 164 yards in Week 1, he had 72 against the Panthers in Week 2, 81 against the Cowboys the following week, and 146 last week against the Bears. Green Bay is giving up 126 a game and is struggling to keep its offense on the field.

As for Cooper Kupp, he’ll have his work cut out for him against the Dallas defense. But Kupp gets targeted so much by Matthew Stafford (54 times through four games; 19 last week) that he’ll still probably have at least nine receptions.

For more: Best NFL parlay apps | Learn more about parlay betting odds


About the Author
Travis Pulver

Travis Pulver

Senior Writer
Travis Pulver is a senior writer for Gaming Today and a lifelong football fan, something he says comes naturally having been born in the football-crazy state of Texas. Through the years, Pulver's love of sports has extended into baseball, basketball, golf, and rugby. Life currently finds him in Indiana with his wife and two kids.

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