NFL Week 1 Odds: Bills vs. Rams, Bucs vs. Cowboys, Broncos vs. Seahawks Highlight 2022 Season Openers is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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With Thursday night’s release of the 2022 NFL schedule, sportsbooks are adding Week 1 odds to their wagering menus. The season opens with Bills vs. Rams on Thursday, September 8, the Bucs visit the Cowboys on Sunday Night Football, and the first Monday night game of the season features Russell Wilson’s return to Seattle as a member of the Denver Broncos.

The NFL traditionally opens the season at the home of the defending Super Bowl champs — in this case, SoFi Stadium near Los Angeles. There is early disagreement among sportsbooks as to the favorite in this game.

Opening odds at SuperBook USA have the Rams priced as short favorites with a total of 52.5, per a tweet from director John Murray, while FanDuel went Buffalo -1 (-105) with a total of 51.5.

BUF Bills vs LA Rams Odds NFL Odds

NFL · Thu (9/8) @ 8:20pm ET

BUF Bills at LA Rams
SoFi Stadium, Inglewood, California

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Sunday Night Football Opener

For the second year in a row, the Bucs and Cowboys open the season against each other, this time in Dallas. Again, there’s a discrepancy between the SuperBook and FanDuel, the former opening Tampa -1.5 (52), the latter dealing Tampa -2.5 (51.5).

In Week 1 last season, the Bucs prevailed 31-29 at home but failed to cover the 10-point spread.

TB Buccaneers vs DAL Cowboys Odds NFL Odds

NFL · Sun (9/11) @ 8:20pm ET

TB Buccaneers at DAL Cowboys
AT&T Stadium, Arlington, Texas

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Broncos vs. Seahawks Opens MNF

Wilson’s Broncos open as road favorites against his former mates. The SuperBook has Denver -3.5 with a total of 41, while FanDuel offers Seattle +4.5 (42.5).

Broncos vs. Seahawks also marks the debut of Joe Buck and Troy Aikman on ESPN’s MNF telecasts.

DEN Broncos vs SEA Seahawks Odds NFL Odds

NFL · Mon (9/12) @ 8:15pm ET

DEN Broncos at SEA Seahawks
Lumen Field, Seattle, Washington

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More Week 1 Betting Lines

Here is the rest of the Week 1 slate, with point spreads and totals from the SuperBook, one of the first books to post these numbers. All of these games are scheduled for Sunday, Sept. 11.

Ravens (-4.5, 45) at Jets
Saints (-3.5, 42) at Falcons
Patriots at Dolphins (-3, 45)
Browns (-4.5, 43.5) at Panthers
Steelers at Bengals (-6.5, 44.5)
49ers (-6.5, 42) at Bears
Eagles (-4, 46.5) at Lions
Colts (-8, 44) at Texans
Jaguars at Commanders (-3.5, 44)
Chiefs (-3, 53) at Cardinals
Raiders at Chargers (-4, 51.5)
Packers (-2, 49) at Vikings
Giants at Titans (-6.5, 44)

Check back at Gaming Today over the next several days, as we’ll have plenty more betting information on the NFL’s 2022 schedule.

Also read: NFL Christmas Day odds | Betting Lines for International Games | NFL season win totals 

About the Author

Marcus DiNitto

Sr. News Editor
Marcus DiNitto is Senior News Editor for Gaming Today. He has been managing editor at SportsBusiness Daily, Sporting News, The Linemakers, and USA Sports Gaming. Marcus earned his MBA from the University of North Carolina-Charlotte.

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