NFL Week 1 Odds: Chiefs & Bills Favored in Big Season Openers

GamingToday.com is an independent sports news and information service. GamingToday.com has partnerships with some of the top legal and licensed sportsbook companies in the US. Gaming Today may receive referral compensation from the sportsbook company when you claim a bonus offer or promotion through a link on this site. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

For more information, please read How We Rate Sportsbooks, Privacy Policy, or Contact Us with any concerns you may have.

Gaming Today is licensed and regulated to operate in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, ME, MI, MS, NJ, NV, NY, OH, ON, PA, TN, VA, VT, WV, and WY.

The 2023 NFL season is upon us, and there’s a prevailing sense of optimism as teams begin with a clean slate in the hope of reaching Super Bowl 58.

NFL Week 1 odds are available at top-rated sportsbooks. After Lions vs. Chiefs kicks off the new campaign on Thursday, Sept. 7, matchups between the Dolphins-Chargers, Eagles-Patriots, and Cowboys-Giants take center stage on Sunday, Sept. 10.

One of the most anticipated tilts of opening week comes on Monday Night Football when Aaron Rodgers makes his debut for the Jets, as they host Josh Allen and the Bills in an AFC East showdown.

It’s good to have football back, and let’s now take a look at all 16 games from a betting perspective.

Betting Odds for Week 1 of the 2023 NFL Season

Here are point spreads, totals, and moneylines for games on the Week 1 card.

NFL Week 1 Lines

Here’s a game-by-game look at NFL Week 1 with odds from around the sports betting market place.

Get up to $1,500 in Bonus Bets at BetMGM Sportsbook
1
up to $1,500
In Bonus Bets
Up to $1,500 in Bonus Bets if Your First Bet Doesn't Win*
*Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms
21+. Gambling Problem? Call 1-800-GAMBLER
Use Bonus Code: TODAY

Lions at Chiefs (Thursday, Sept. 7)

The defending Super Bowl champions are laying close to a touchdown against a rejuvenated Detroit team that’s expected to put up some points this year. That helps explain the biggest total on the Week 1 betting card here.

For all its success last season, Kansas City was dismal against the spread (ATS) at home. The Chiefs went 3-6-1 ATS at Arrowhead Stadium, ranking 28th of the NFL’s 32 teams in that metric.

Detroit was 12-5 ATS overall and 5-3 ATS on the road last year. With Jared Goff back at QB, the Lions have a new RB tandem with David Montgomery and first-round draft pick Jahmyr Gibbs out of Alabama.

The Chiefs start the season as a consensus +600 betting favorite to win Super Bowl 58.

NFL Week 1 Odds
Chiefs quarterback Patrick Mahomes (15) and tight end Travis Kelce (87) are back to defend their Super Bowl title. (AP Photo/Rick Scuteri)

Bills at Jets (Monday)

This line opened Buffalo -3 when the 2023 schedule was released in May. Of course, Rodgers later (and finally) made his way to the Jets. Will that change the pecking order in the AFC East this season?

The Jets are expected to be stout on defense again after giving up just 18.6 points per game last season. Pro Football Focus ranks New York’s defense third — one spot behind Buffalo.

On offense, QB Josh Allen has top targets Stefon Diggs and Gabe Davis back in the fold. RB James Cook has company in the backfield with the arrival of veterans Latavius Murray and Damien Harris in the offseason.

It’s only one game and the first of the year, but this result could portend big things for two of the AFC East’s most talented teams.

Dolphins at Chargers

Can Tua Tagovailoa stay off the sidelines this season? If the answer is yes, the Dolphins should also make a bid for the AFC East title.

This season opener is a rematch of last December’s game in LA. The Chargers prevailed 23-17 as a 3.5-point home underdog. Justin Herbert outperformed Tagovailoa, throwing for 300+ yards and a TD. Tyreek Hill entered the game as questionable, but ended up scoring a pair of TDs in a losing cause.

Herbert has the same potent cast of characters on offense in Austin Ekeler, Keenan Allen, and Mike Williams. Like Miami, LA has the firepower to compete for a title in the AFC West.

Stay Updated: Live Super Bowl Futures Odds

Bengals at Browns

Cincinnati QB Joe Burrow should be fine for this slugfest between in-state rivals. Burrow was carted off the field with a calf injury in late July but appears to be fully recovered as the regular season draws near.

Fun fact: Cleveland has owned this series in recent years, going 5-1 straight-up (SU) in the last six meetings dating back to the first COVID season in 2020.

The Browns have one of the NFL’s best rushing attacks behind bellcow RB Nick Chubb. Cleveland was sixth in the NFL last season with 2,490 rushing yards. But head coach Kevin Stefanski is expected to utilize a more pass-heavy attack with QB Deshaun Watson this year.

Eagles at Patriots

We live in a short-attention span world, but it’s difficult to forget the Eagles storming out to an 8-0 record last season. The NFC’s Super Bowl representative finished 14-3 in the regular season.

Jalen Hurts inked a lucrative long-term extension, and he’s got A.J. Brown and DeVonta Smith back as top receiving threats.

The Eagles acquired RBs D’Andre Swift and Rashaad Penny in the offseason. They’ll likely reduce the running workload for Hurts, who was the team’s second leading rusher last season.

In New England, Bill O’Brien is back as offensive coordinator and reunites with former Alabama QB Mac Jones. The Patriots recently added former Cowboys RB Ezekiel Elliott to the fold. New England’s futures odds peg the Pats as a longshot across the board.

Cowboys at Giants (Sunday Night)

Dak Prescott has publicly vowed to cut down on his interception total this season. The Giants are moving ahead with Daniel Jones at QB after signing him to a four-year, $160 million contract. Pro Football Focus put the Dallas defense at the top of its rankings heading into the season. Hope always runs high in Big D this time of year, but Philadelphia is still top dog in the NFC East.

The Rest of NFL Week 1 Games

Panthers at Falcons

The NFC South is wide open, and either of these teams could emerge as the division winner.

No. 1 draft pick Bryce Young makes his NFL debut for the Panthers, and big things are also expected for fellow first-rounder Bijan Robinson in Atlanta’s backfield this year.

Jaguars at Colts

Jacksonville gave Kansas City everything it could handle in last year’s 27-20 playoff loss at Arrowhead. The Jags are one of the league’s most intriguing teams entering the 2023 season based on their futures odds.

49ers at Steelers

The 49ers are absolutely loaded on offense with RBs Christian McCaffrey and Elijah Mitchell, along with pass catchers Deebo Samuel, Brandon Aiyuk, and George Kittle. Brock Purdy gets the nod as the starting QB?

In Pittsburgh, QB Kenny Pickett has played to rave reviews in the preseason, and many pundits are expecting the Steelers to surge in the AFC North this year.

Titans at Saints

As you saw from the NFC South futures above, New Orleans begins the season as the betting favorite to win the division. The Saints will be without their biggest offensive weapon in Alvin Kamara through the end of September. One of the league’s most talented RBs, Kamara was suspended for violating the NFL’s personal conduct policy.

Shop around on the top sports betting apps for the best odds here, as Saints -3 and Titans +3.5 are both available as of this update. For underdog bettors, that hook could come in handy on the road.

Raiders at Broncos

The Broncos were putrid on offense last year averaging a league-worst 16.9 points per game. Can new coach Sean Payton help QB Russell Wilson return to prominence? Denver upgraded its offensive line during the offseason. That should help the cause.

Rookie QB Aidan O’Connell has performed well for Las Vegas in the preseason, but expect newly arrived Jimmy Garoppolo to be the one throwing to stud WR Davante Adams to start the season.

Rams at Seahawks

The Seahawks enjoyed a resurgence last year under QB Geno Smith, who was named 2022 NFL Comeback Player of the Year. Kenneth Walker III was a revelation as a rookie RB, rushing for more than 1,000 yards and scoring nine times on the ground. DK Metcalf and Tyler Lockett return to give Seattle one of the most productive WR duos in the league.

It’s hard to fathom it was only 18 months ago when the Rams were crowned Super Bowl champions. LA, in the midst of a complete rebuild, still has Matt Stafford and Cooper Kupp to create occasional moments of excitement on offense. But if it weren’t for the Cardinals, the Rams might be staring down a last-place finish in the NFC West.

Packers at Bears

Jordan Love appeared in only 10 games as an apprentice to Aaron Rodgers in his two seasons with Green Bay. His baptism by fire begins against the Bears, who were famously “owned” by the Packers under Rodgers.

QB Justin Fields is coming into his own for Chicago, which has a shiny new toy in WR DJ Moore. Expect a reversal of both teams’ fortunes in the NFC North moving ahead.

Cardinals at Commanders

A quick look at Arizona’s futures odds (+20000 at Caesars to win Super Bowl) tells you a lot about where this team stands at the outset of the season.

The Cardinals are also among the betting favorites to have the worst record of the year at top-rated NFL betting sites. New coach, new GM, and lousy roster. Starting QB Kyler Murray is also likely to miss this game as he recovers from an ACL injury suffered late last year.

There’s no good reason to bet on Arizona now — and maybe moving forward.

Texans at Ravens

Baltimore is laying the biggest number on the opening week card here. Houston’s success (or lack thereof) depends in large part on how quickly rookie QB C.J. Stroud can develop. This looks like a tough nut to crack in his professional debut.

Bucs at Vikings

The Baker Mayfield era officially begins for the Bucs. It didn’t last long in Carolina last year, so enjoy him while you can Tampa Bay fans.

More NFL Betting Analysis

About the Author
Kris Johnson

Kris Johnson

Senior Writer
Kris Johnson is a senior writer at Gaming Today with more than 15 years of experience as a sports journalist. Johnson's work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and other publications. He also authored a sports betting novel titled The Endgame.

Get connected with us on Social Media