NFL Week 10 Odds: Vikings-Bills Betting Line Shifts on Josh Allen’s Injury Uncertainty

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The NFL’s top storyline all week has centered on Bills QB Josh Allen’s elbow injury, and his uncertain status for Sunday’s game against the Vikings.

Allen was a non-participant in practice again on Thursday, and it’s looking more likely that backup Case Keenum with get the start against Minnesota.

Meanwhile, after a week in which three double-digit favorites all failed to cover, NFL Week 10 odds feature the Eagles as the only big chalk on the betting board.

The MNF matchup opened Philadelphia -10.5 over Washington at DraftKings. It’s now Eagles -11 as of Friday, Nov. 11.

The Week 10 slate also features an intriguing matchup between the Seahawks and Bucs, both winners last weekend, in the first-ever regular season game to be played in Germany.

Four teams are on a bye in Week 10: Ravens, Bengals, Patriots, and Jets.

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Betting Lines for Week 10 of the 2022 NFL Season

Here are point spreads, totals, and moneylines for games on the Week 10 card.

Bet TypeSpreads
Open
Thu (11/10) @ 8:15pm ET ATL Falcons -141 +1800 +1400 +750 +1500 +1800
CAR Panthers +115 -10000 -10000 -1250 -10000 -5000
Sun (11/13) @ 9:30am ET SEA Seahawks +100 +520 +550 +475 +130 +540 +1000
TB Buccaneers -120 -769 -1000 -714 -149 -909 -1667
Sun (11/13) @ 1:00pm ET HOU Texans +240 +2500 +2200 +5000 +190 +560 +4500
NY Giants -303 0 -10000 0 -222 -1000 0
Sun (11/13) @ 1:01pm ET NO Saints -149 +1000 +825 +1000 +1060 +5000
PIT Steelers +125 -2000 -2000 -2000 -3333 0
Sun (11/13) @ 1:02pm ET JAX Jaguars +350 +2500 +1500 +700 +700 +2800
KC Chiefs -455 0 -2500 -1250 -1429 -10000
Sun (11/13) @ 1:02pm ET CLE Browns +165 +1800 +3300 +1000 +2500 +2500
MIA Dolphins -200 -10000 -10000 -2000 0 -10000
Sun (11/13) @ 1:02pm ET DET Lions +115 -323 -2000 -5000 -135 -5000
CHI Bears -141 +255 +700 +1400 +106 +1500
Sun (11/13) @ 1:02pm ET MIN Vikings +260 +240 +200 +270 +196 0
BUF Bills -345 -303 -278 -345 -263 0
Sun (11/13) @ 1:02pm ET DEN Broncos +125 +2500 +3300 +850 +1000 0
TEN Titans -149 0 -10000 -1667 -3333 0
Sun (11/13) @ 4:05pm ET IND Colts +200 -196 -154 -179 +182 -238 -227
LV Raiders -250 +160 +115 +150 -208 +182 +185
Sun (11/13) @ 4:24pm ET ARI Cardinals +155 -5000 -714 -2500 +153 -5000 -769
LA Rams -189 +1300 +475 +1100 -179 +1400 +500
Sun (11/13) @ 4:24pm ET DAL Cowboys -227 -10000 -1667 -5000 -196 -5000 -2500
GB Packers +180 +1600 +775 +1600 +170 +1400 +1300
Sun (11/13) @ 8:20pm ET LA Chargers +220 +275 +260 +278 +275 +285 +280
SF 49ers -278 -333 -345 -357 -333 -357 -345
Mon (11/14) @ 8:15pm ET WAS Commanders +375 -625 -1250 -1000 -909 0
PHI Eagles -500 +440 +600 +625 +540 0
Thu (11/10) @ 8:15pm ET ATL Falcons -2.5 -110 +12.5 -141 +11.5 -110 +10.0 -1250 +12.5 -104 +9.5 0
CAR Panthers +2.5 -110 -12.5 +110 -11.5 -115 -10.0 +700 -12.5 -125 -9.5 0
Sun (11/13) @ 9:30am ET SEA Seahawks +1.5 -110 +11.5 +145 +5.5 -714 +12.5 -208 +2.5 -105 +11.5 +162 +12.0 +105
TB Buccaneers -1.5 -110 -11.5 -179 -5.5 +425 -12.5 +170 -2.5 -118 -11.5 -213 -12.0 -120
Sun (11/13) @ 1:00pm ET HOU Texans +6.5 -110 +11.5 -270 +8.5 -2500 +8.0 +475 +5.0 -112 +8.5 -667 +11.0 -105
NY Giants -6.5 -110 -11.5 +215 -8.5 +900 -8.0 -714 -5.0 -109 -8.5 +410 -11.0 -110
Sun (11/13) @ 1:01pm ET NO Saints -3.0 -105 +9.5 +300 +9.5 +270 +9.5 +250 +9.5 +320 +10.0 -303
PIT Steelers +3.0 -115 -9.5 -400 -9.5 -370 -9.5 -323 -9.5 -476 -10.0 +240
Sun (11/13) @ 1:02pm ET JAX Jaguars +10.0 -110 +9.5 +275 +9.5 +155 +10.0 +210 +10.5 -213 +10.0 0
KC Chiefs -10.0 -110 -9.5 -357 -9.5 -208 -10.0 -263 -10.5 +162 -10.0 0
Sun (11/13) @ 1:02pm ET CLE Browns +4.0 -110 +21.5 +200 +21.5 +115 +22.0 +290 +21.5 +260 +22.0 +135
MIA Dolphins -4.0 -110 -21.5 -250 -21.5 -149 -22.0 -385 -21.5 -370 -22.0 -161
Sun (11/13) @ 1:02pm ET DET Lions +2.5 -110 +1.5 +135 +1.5 +100 +5.5 +105 +1.5 -108 +5.5 +110
CHI Bears -2.5 -110 -1.5 -164 -1.5 -130 -5.5 -135 -1.5 -120 -5.5 -130
Sun (11/13) @ 1:02pm ET MIN Vikings +7.5 -110 +0.5 +100 +6.5 +110 +12.5 +105 +4.5 -588 +6.5 -108
BUF Bills -7.5 -110 -0.5 -130 -6.5 -145 -12.5 -135 -4.5 +365 -6.5 -108
Sun (11/13) @ 1:02pm ET DEN Broncos +3.0 -115 +3.5 +195 +3.5 +180 +3.5 +195 +3.5 +220 +4.0 +110
TEN Titans -3.0 -105 -3.5 -238 -3.5 -250 -3.5 -238 -3.5 -303 -4.0 -125
Sun (11/13) @ 4:05pm ET IND Colts +5.5 -110 -1.5 +130 -1.5 +125 -2.5 +105 +4.5 -110 -1.5 +120 +0.5 +110
LV Raiders -5.5 -110 +1.5 -161 +1.5 -161 +2.5 -135 -4.5 -110 +1.5 -156 -0.5 -130
Sun (11/13) @ 4:24pm ET ARI Cardinals +3.5 -110 -10.5 +120 -6.5 -200 -9.5 -135 +3.5 -118 -10.5 +106 -7.0 +135
LA Rams -3.5 -110 +10.5 -149 +6.5 +150 +9.5 +105 -3.5 -103 +10.5 -139 +7.0 -161
Sun (11/13) @ 4:24pm ET DAL Cowboys -4.5 -110 -13.5 -135 -11.5 -110 -13.5 -141 -3.5 -114 -14.5 +106 -11.5 -108
GB Packers +4.5 -110 +13.5 +105 +11.5 -120 +13.5 +110 +3.5 -108 +14.5 -139 +11.5 -108
Sun (11/13) @ 8:20pm ET LA Chargers +6.5 -110 +7.5 -110 +7.5 -110 +7.5 -110 +7.5 -109 +7.5 -110 +7.5 -108
SF 49ers -6.5 -110 -7.5 -110 -7.5 -110 -7.5 -110 -7.5 -112 -7.5 -110 -7.5 -108
Mon (11/14) @ 8:15pm ET WAS Commanders +10.5 -110 -1.5 -120 -1.5 -141 -2.5 +110 -1.5 -135 -2.0 -108
PHI Eagles -10.5 -110 +1.5 -110 +1.5 +105 +2.5 -141 +1.5 +104 +2.0 -108
Thu (11/10) @ 8:15pm ET ATL Falcons o42.5 -110 o37.5 -149 o37.5 -189 o37.5 -213 o36.5 0
CAR Panthers u42.5 -110 u37.5 +120 u37.5 +155 u37.5 +162 u36.5 0
Sun (11/13) @ 9:30am ET SEA Seahawks o44.5 -110 o36.5 -135 o39.5 +210 o45 -110 o45.0 -109 o36.5 -118 o38.5 +350
TB Buccaneers u44.5 -110 u36.5 +105 u39.5 -303 u45 -110 u45.0 -112 u36.5 -110 u38.5 -455
Sun (11/13) @ 1:00pm ET HOU Texans o38.5 -110 o33.5 -125 o33.5 -105 o40.5 -110 o41.5 -112 o40.5 -118 o33.5 -110
NY Giants u38.5 -110 u33.5 -105 u33.5 -125 u40.5 -110 u41.5 -109 u40.5 -110 u33.5 -105
Sun (11/13) @ 1:01pm ET NO Saints o41.5 -110 o36.5 -149 o36.5 -120 o36.5 -125 o31.5 +200
PIT Steelers u41.5 -110 u36.5 +120 u36.5 -110 u36.5 -104 u31.5 -250
Sun (11/13) @ 1:02pm ET JAX Jaguars o49.5 -110 o44.5 +105 o47.5 +115 o44.5 +120 o44.5 +100
KC Chiefs u49.5 -110 u44.5 -135 u47.5 -149 u44.5 -154 u44.5 -115
Sun (11/13) @ 1:02pm ET CLE Browns o48.5 -110 o57.5 -115 o61.5 -110 o56.5 -122 o63 +125
MIA Dolphins u48.5 -110 u57.5 -115 u61.5 -120 u56.5 -106 u63 -145
Sun (11/13) @ 1:02pm ET DET Lions u48.5 -110 u61.5 -125 u61.5 -161 u61.5 -122 u60 -108
CHI Bears o48.5 -110 o61.5 -105 o61.5 +125 o61.5 -104 o60 -108
Sun (11/13) @ 1:02pm ET MIN Vikings u48 -110 u50.5 +110 u50.5 +140 u54.5 -130 u50.5 +115
BUF Bills o48 -110 o50.5 -141 o50.5 -175 o54.5 +100 o50.5 -135
Sun (11/13) @ 1:02pm ET DEN Broncos o39 -110 o27.5 -110 o28.5 +105 o32.5 -115 o27 -125
TEN Titans u39 -110 u27.5 -120 u28.5 -141 u32.5 -114 u27 +110
Sun (11/13) @ 4:05pm ET IND Colts o42 -110 o45.5 -110 o45.5 +105 o41.0 -108 o45.5 -106 o45 -115
LV Raiders u42 -110 u45.5 -120 u45.5 -130 u41.0 -114 u45.5 -120 u45 +100
Sun (11/13) @ 4:24pm ET ARI Cardinals o43.5 -110 o36.5 -135 o33.5 -120 o38.0 -108 o36.5 -114 o33 -115
LA Rams u43.5 -110 u36.5 +105 u33.5 -110 u38.0 -114 u36.5 -114 u33 +100
Sun (11/13) @ 4:24pm ET DAL Cowboys o43.5 -110 o51.5 -135 o55.5 -115 o44.5 -110 o52.5 +112 o54.5 -108
GB Packers u43.5 -110 u51.5 +105 u55.5 -105 u44.5 -110 u52.5 -147 u54.5 -108
Sun (11/13) @ 8:20pm ET LA Chargers o46.5 -110 o45.5 -110 o45.5 -110 o45.5 -110 o45.5 -112 o45.5 -110 o45.5 -108
SF 49ers u46.5 -110 u45.5 -110 u45.5 -110 u45.5 -110 u45.5 -109 u45.5 -110 u45.5 -108
Mon (11/14) @ 8:15pm ET WAS Commanders u44.5 -110 u54.5 -110 u53.5 +100 u54.5 -128 u53.5 -108
PHI Eagles o44.5 -110 o54.5 -120 o53.5 -130 o54.5 -102 o53.5 -108

NFL Week 10 Lines

Here’s a game-by-game look at NFL Week 10 betting odds via DraftKings, which are current as of Friday, Nov. 11.

Vikings at Bills (-3.5, 43.5)

The Bills opened -7.5 here but the line swung a full four points in favor of Minnesota on the news of Allen’s elbow injury. If Buffalo (6-2) loses, there’s a good chance it will no longer be the AFC East’s solo leader. The Dolphins (6-3) face the Cleveland Browns at home on Sunday.

Super Bowl 2022 Odds: Bills Still the Clear Favorite Amid Josh Allen Injury
Buffalo Bills quarterback Josh Allen (AP Photo/Noah K. Murray)

Seahawks at Buccaneers (-2.5, 44.5) — Munich, Germany

This line opened Tampa Bay -1 and bettors have pushed it to Bucs -2.5. Much has been made of Tom Brady’s performances overseas, but the Bucs are still in offensive disarray.

Seattle brings a balanced offense behind QB Geno Smith, RB Kenneth Walker III, and WRs DK Metcalf and Tyler Lockett. Walker has seven rushing TDs in his last five games. The Bucs have three all season.

Love Seattle outright in this one across the pond.

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Lions at Bears (-2.5, 48.5)

No movement here on the spread. After the Bears started the season as one of the NFL’s lowest scoring teams, four of Chicago’s last five games have gone Over.

Jaguars at Chiefs (-9, 51)

For all their greatness, the Chiefs are 0-4 ATS at home this season. This line ticked toward the road dog after opening Kansas City -9.5.

Browns at Dolphins (-3.5, 49.5)

Since the return of Tua, the Dolphins have reeled off three straight wins. Miami can grab a share of the AFC East division lead with a win over the Browns and a loss by the Bills.

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Cowboys (-4.5, 42.5) at Packers

Green Bay is 8-1 straight-up over Dallas in the last nine meetings between these two teams. But the Packers are in disarray and the Cowboys are 6-1 ATS in their last seven tilts.

Cardinals at Rams (-1.5, 40.5)

An NFC West battle between struggling three-win teams here. The Rams opened -3 but bettors are showing little faith in the defending Super Bowl champions.

Chargers at 49ers (-7, 45.5)

It sure feels like San Francisco is poised to make a run coming off its bye week at 4-4. The 49ers are 6-1 ATS in their last seven home games.

Commanders at Eagles (-11, 44) — Monday

Home favorites have been a losing proposition this season, covering at a clip of just 42.1%. Philadelphia’s performances at home fly in the face of that league trend. The Eagles are 4-0 ATS at Lincoln Financial Field. But Philadelphia (-14) did fail to cover in last week’s 29-17 win at Houston.

The Rest of NFL Week 10 Games

Texans at Giants (-4.5, 41)

Bettors have backed the Texans during the week after this opened at Giants -7. Saquon Barkley should feast against Houston’s porous run defense here.

Colts at Raiders (-4.5, 40.5)

Las Vegas has struggled mightily, but this might be a prime time to buy low on the Raiders. Las Vegas opened -6.

Saints (-1.5, 40) at Steelers

The Under has hit in six of Pittsburgh’s last seven home games.

Broncos at Titans (-2.5, 40)

Another prime candidate to go Under here based on trends. The total has gone Under in seven of Denver’s last eight games — and in Tennessee’s last five tilts.

Also readCowboys-Packers odds and prediction | Chargers vs. 49ers | Commanders vs. Eagles

About the Author
Kris Johnson

Kris Johnson

Writer & Contributor
Kris Johnson is a Senior Writer at Gaming Today with more than 15 years of experience as a sports journalist. Kris' work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and more. Kris also authored a sports betting novel entitled The Endgame.

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