Week 10 in the NFL pales in comparison to Week 9 in terms of must-see match-ups, but there’s still plenty of intrigue as we enter the second half of the season. Sunday’s Germany game won’t have the same feel as the Dolphins-Chiefs from a week ago. Still, Colts-Patriots at 9:30 will provide a solid appetizer before a 1 p.m. window featuring an AFC North battle between Cleveland and Baltimore and intriguing clashes between the Texans and Bengals, and 49ers and Jaguars.
We recommend the best NFL betting sites in Gaming Today’s overview of the odds for the best games of Week 10. Let’s break down the best NFL Week 10 odds and analyze a few of the best matchups here.
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Week 10 NFL Odds & Betting Picks, Analysis
Cleveland Browns (5-3) at Baltimore Ravens (7-2)
- Time: Sunday, 1:00 p.m. ET
- TV/Live Stream: FOX
The Ravens are rolling right now, and the biggest question about this team might be whether it’s more imposing offensively or defensively. Baltimore’s D smothered good offenses in two of the last three weeks (Detroit in Week 7 and Seattle in Week 9). That likely means the Browns will be in for a long day on Sunday. Cleveland took a big step in the right direction last Sunday, shutting out Arizona 27-0 as Deshaun Watson played well in his return from injury.
Against Baltimore (in Baltimore), however, I still don’t trust a Cleveland team that lost the previous meeting between these teams 28-3. Going with the Ravens laying the points against their AFC North rival is a risk worth taking this week.
Pick: Ravens (-5.5 at time of publishing)
Houston Texans (4-4) at Cincinnati Bengals (5-3)
- Time: Sunday, 1:00 p.m. ET
- TV/Live Stream: CBS
The Bengals have put together back-to-back statement wins. With Joe Burrow’s early-season calf injury and related struggles now a distant memory, the Bengals look like a legitimate contender in the AFC. Houston has shown flashes that it could be a wild-card team in CJ Stroud’s first season. His best performance came in Week 9, as he exploded for a historic day for a rookie in his team’s last-second win over the Buccaneers. Stroud and the Houston offense have a high ceiling. Still, inconsistency has been an issue (the Texans were limited to just 13 points in Week 8 against Carolina, and they scored nine points in the opener against Baltimore).
The Bengals are playing too well to pick against them, but it’s hard to see them winning this one by more than one touchdown.
Pick: Bengals (-7 at time of publishing)
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Detroit Lions (6-2) at Los Angeles Chargers (3-4)
- Time: Sunday, 4:05 p.m. ET
- TV/Live Stream: CBS
Detroit dominated the Raiders in Week 8 and is coming off a bye week, making the Lions a formidable opponent for the Chargers. L.A. is coming off a tough Monday Night Football battle with the Jets. QB Justin Herbert gives the Chargers a chance in every game, but Detroit is the better team, and the Chargers’ lack of a real homefield advantage makes Detroit great value as the slight road favorite.
Pick: Lions (-1.5 at time of publishing)
Denver Broncos (3-5) at Buffalo Bills (5-4)
- Time: Monday, 8:15 p.m. ET
- TV/Live Stream: ABC, ESPN
There’s no questioning Bills QB Josh Allen’s talent. He is once again carrying the Buffalo offense (he’s completing over 70 percent of his passes and averaging 7.5 yards per attempt). His nine interceptions are a big reason his team is in danger of missing the playoffs, though. Allen has thrown a pick in his team’s last five games, and the Bills are 2-3 over that stretch. If he can’t avoid the turnovers, Buffalo might be out of playoff contention by the start of December: its next three opponents after Denver are the Jets, Eagles, and Chiefs.
The Broncos played their best game of the season in Week 8, when they beat Kansas City 24-9, and they were on the bye in Week 9. Denver will look to show against Buffalo that its defense, which was awful early in the season, has figured it out (the Broncos have given up 20 or less in their last three games, including two against the Chiefs). I like the Broncos to cover in a low-scoring game but not quite pull off the upset. It helps Denver’s case for covering that since blowing out the Raiders, Commanders, and Bills early this year, Buffalo hasn’t won a game by more than 6 points since Oct. 1.
Pick: Broncos (+7.5 at time of publishing)
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