NFL Week 10 Betting Picks & Predictions: One Favorite, One Underdog, and One Total is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. Gaming Today may receive referral compensation from the sportsbook company when you claim a bonus offer or promotion through a link on this site. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

For more information, please read How We Rate Sportsbooks, Privacy Policy, or Contact Us with any concerns you may have.

Gaming Today is licensed and regulated to operate in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, ME, MI, MS, NJ, NV, NY, OH, ON, PA, TN, VA, VT, WV, and WY.

Tampa Bay Bucs QB Tom Brady is featured in our NFL Week 10 betting picks & predictions: one favorite, one underdog, and one total. (AP Photo/Ben VanHouten)

Week 10 has arrived and the NFL is turning the page to the second half of the season. With nine weeks of games so far, the race for a postseason berth is tightening in each conference.

Last week, like most in any turbulent NFL season, was full of upsets and bad beats that had many bettors pulling out their hair. As we review this weekend’s slate in our NFL Week 10 betting picks and predictions, we take a look at the best bets in an action-packed Sunday that also includes the first-ever regular season game in Munich, Germany.

Seattle Seahawks vs. Tampa Bay Buccaneers (-2.5)

The fourth of five international games this season, the NFL takes over Bayern Munich’s Allianz Arena Sunday morning in Germany. With the Seahawks taking on the Buccaneers, few expected Seattle to enter this game with a two-game advantage over Tampa Bay.

SEA Seahawks vs TB Buccaneers Odds NFL Odds

NFL · Sun (11/13) @ 9:30am ET

SEA Seahawks at TB Buccaneers
Raymond James Stadium, Tampa, Florida

Use Bonus Code TODAY for $1,000 Risk Free Bet at BetMGM

Tom Brady and the Bucs ended a three-game skid last week with a crucial 16-13 comeback win over the Los Angeles Rams. Despite the Buccaneers’ 4-5 record, they’re a short favorite in this pivotal NFC matchup and one of our best bets for NFL Week 10. 

The GOAT is 3-0 in international games with all three victories coming as a member of the New England Patriots. Nothing has been pretty in the bay this season with off-field drama dominating the storylines. Off a key comeback win against the Rams, a neutral venue nearly 5,000 miles away in a foreign country may actually be beneficial for this team.

Seattle, one of the year’s most surprising teams, is riding a four-game winning streak and is fresh off a 31-21 win over divisional rival Arizona. Quarterback Geno Smith and the first-place Seahawks have relied on Offensive Rookie of the Year frontrunner Kenneth Walker III to run all over defenses. The rookie has logged a touchdown in five straight games including five scores in the last three.

Smith and Walker III will have their hands full against a tough Tampa Bay defense. Although not performing as well as their pre-season expectations, the Bucs have allowed the ninth-fewest yards per game. The Hawks haven’t faced a gauntlet by any stretch during their winning streak, facing teams ranked 17th, 21st, and 26th (twice) by yards allowed.

In a battle of two divisional leaders, the edge goes to the more experienced team that may have finally righted the ship. The Seahawks’ Cinderella season has been special so far — and is far from over — but the best bet of NFL Week 10 is Tampa Bay with the points in Munich.

Read: NFL Week 10 betting trends

Denver Broncos (+3) at Tennessee Titans

After trading for Russell Wilson in the offseason, the Denver Broncos were a preseason darling and expected to compete in a stacked AFC West. After a four-game skid, the 3-5 Broncos got back in the win column with a 21-17 victory over Jacksonville before heading into their bye last week.

DEN Broncos vs TEN Titans Odds NFL Odds

NFL · Sun (11/13) @ 1:02pm ET

DEN Broncos at TEN Titans
Nissan Stadium, Nashville, Tennessee

Bet NFL at Caesars: Up to $1,250 First Bet + 1000 Tier Credits + 1000 Reward Credits®

On a road trip to face the AFC South leaders, the Broncos match up well against the Titans and are one of our best bets for NFL Week 10.

The Denver defense has been suffocating opposing offenses this season. One of the league’s top units, the Broncos rank second in QBR allowed, yards per game, and points per game. They’ll have a favorable matchup against a Titans team that is averaging the fewest offensive yards per game in the league.

Like other quarterbacks facing the Broncos this season, Titans signal caller Malik Willis will have an uphill battle against a tough Denver defense. Replacing an injured Ryan Tannehill, the rookie has thrown only 11 completions in his two starts this season with fewer than 150 yards, one interception, and no touchdowns. 

Despite his archaic stat line, the former Liberty quarterback hasn’t lost in regular time as a starter, going 1-1 overall with an overtime loss to Kansas City. The offense has relied on All-Pro running back Derrick Henry to move the ball but the Broncos’ front seven will be a tougher task. If the defense can keep King Henry in check, Denver is primed for a road upset.

Coming out of their bye, Denver needs to string together wins to keep up in a crowded wildcard race. Denver is 7-1 against the spread in their last eight against Tennessee and should keep it close against this Titans squad. Neither team boasts potent offenses and points may be difficult to come by. With a total set in the upper 30s, the Broncos getting a field goal is the safer play in this one.

In our Week 10 NFL predictions, the Broncos keep Henry in check and the secondary proves too much for rookie Malik Willis to overcome. It won’t be the prettiest game of the weekend but Denver will come out on top, 17-16.

Look ahead: NFL Week 11 odds | Super Bowl 2022 odds

Jacksonville Jaguars at Kansas City Chiefs (Under 50.5)

The Kansas City Chiefs welcome the Jacksonville Jaguars to Missouri as heavy favorites. Both teams are coming off wins with the Chiefs requiring overtime to take down the Titans Sunday Night and the Jags logging a 27-20 win over the lowly Raiders. One of the best bets of NFL Week 10, the under is the play in this AFC matchup.

Quarterback Patrick Mahomes threw the ball 68 times in their overtime win over the Titans. The 6-2 Chiefs’ aerial attack is thriving with tight end Travis Kelce and an ensemble of receivers. Facing a Jaguars’ secondary that has allowed the 10th-most passing yards per game, they shouldn’t have any issue moving the ball.

Whereas the Chiefs can move the ball with ease, the Jaguars’ offense would need to do a lot for a total this high to hit. The Jaguars have struggled after starting the season 2-1, losing five straight before beating the Raiders last week. In their losing streak, they’ve scored over 21 only once — a Week 6 game against the Colts.

Jacksonville will be outmatched in this one and won’t be able to keep up in a shootout with Mahomes and the Chiefs should it come to that. The under is 3-1 in Chiefs games this season after a win.

In our NFL Week 10 predictions, the Chiefs’ high-powered offenses will be able to build a lead and keep the Jaguars at bay. The Chiefs will pull out the dominating home win, 28-13, staying under the posted total of 50.5 in our best bets of NFL Week 10.

Bookmark theseFind the best sportsbook app for you | How to bet on NFL

About the Author
Ken Bates

Ken Bates

Ken Bates is a sports betting writer at Gaming Today. With years of experience in the industry, he’s covered several sports and is always on the lookout for an angle to bet. Bates resides in upstate New York and, as difficult as it may sometimes be, roots for the Jets, Mets, and Islanders.

Get connected with us on Social Media