NFL Week 12 Odds: Opening Lines for the Full 16-Game Slate

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NFL Week 12 odds are available at sportsbooks including DraftKings for the full 16-game slate that kicks off with three games on Thanksgiving Day.  

The Buffalo Bills and Detroit Lions will get things started at 12:30 p.m. ET on Thursday. The New York Giants travel to Dallas to face the Cowboys in a pivotal NFC East matchup on Thanksgiving.

There are no teams on a bye for the first time since Week 5. 

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Point Spreads, Totals, Moneylines on NFL Week 12 Oddsboard

Here’s a look at Week 12 betting lines from top sports betting apps.

Bet TypeSpreads
Open
Thu (11/24) @ 12:34pm ET BUF Bills -370 -1429 -1000 -189 -909 -1667
DET Lions +300 +800 +525 +155 +520 +1000
Thu (11/24) @ 4:35pm ET NY Giants +300 +2500 +3300 +1200 +3500 0
DAL Cowboys -370 0 -10000 -3333 0 0
Thu (11/24) @ 8:23pm ET NE Patriots +135 +2500 +1700 +3000 +125 +2500 0
MIN Vikings -161 0 -10000 0 -141 0 0
Sun (11/27) @ 1:00pm ET TB Buccaneers -164 +300 +1100 +270 -167 +360 +375
CLE Browns +140 -400 -5000 -345 +147 -526 -556
Sun (11/27) @ 1:00pm ET ATL Falcons +155 +2500 +3300 +2000 +165 -156 +5000
WAS Commanders -185 0 -10000 -5000 -189 +122 0
Sun (11/27) @ 1:02pm ET CIN Bengals -120 -1000 -10000 -1111 -1667 -1667
TEN Titans +100 +650 +3300 +650 +800 +850
Sun (11/27) @ 1:02pm ET DEN Broncos -141 +2500 +3300 +1100 +2500 +4500
CAR Panthers +115 0 -10000 -2500 0 0
Sun (11/27) @ 1:02pm ET CHI Bears +200 +800 +3300 +2800 +6500 +9000
NY Jets -250 -1429 -10000 -10000 0 0
Sun (11/27) @ 1:03pm ET HOU Texans +425 +1600 +3300 +2000 +1500 +1700
MIA Dolphins -588 -10000 -10000 -5000 -10000 -5000
Sun (11/27) @ 1:27pm ET BAL Ravens -200 +210 +150 +475 -161 -141 -141
JAX Jaguars +165 -263 -200 -714 +140 +110 +120
Sun (11/27) @ 4:04pm ET LV Raiders +165 -149 -145 -141 +182 -233 0
SEA Seahawks -200 +120 +110 +110 -208 +176 0
Sun (11/27) @ 4:05pm ET LA Chargers -154 -10000 -115 -10000 -143 +106 -3333
ARI Cardinals +130 +2200 -110 +2800 +125 -135 +1300
Sun (11/27) @ 4:24pm ET NO Saints +300 +1400 +1250 +1000 +325 +5500 +4500
SF 49ers -370 -5000 -5000 -2000 -385 0 0
Sun (11/27) @ 4:25pm ET LA Rams +750 +1700 +3300 +1600 +800 +1700 +6600
KC Chiefs -1250 -10000 -10000 -5000 -1111 -10000 0
Sun (11/27) @ 8:22pm ET GB Packers +240 +2500 +1900 +4000 +2500 0
PHI Eagles -303 0 -10000 0 0 0
Mon (11/28) @ 8:14pm ET PIT Steelers +125 -769 -10000 -10000 +120 -1250 -1250
IND Colts -149 +520 +3300 +2500 -137 +630 +700
Thu (11/24) @ 12:34pm ET BUF Bills -9.0 -110 -2.5 -1250 -1.5 -110 -3.0 -120 -2.5 -370 -3.0 +135
DET Lions +9.0 -110 +2.5 +700 +1.5 -120 +3.0 -110 +2.5 +260 +3.0 -161
Thu (11/24) @ 4:35pm ET NY Giants +8.0 -110 +11.5 -130 +14.5 +150 +8.0 +525 +14.5 +630 +15.5 -179
DAL Cowboys -8.0 -110 -11.5 +100 -14.5 -208 -8.0 -833 -14.5 -1250 -15.5 +150
Thu (11/24) @ 8:23pm ET NE Patriots +3.0 -115 +6.5 -110 +4.5 +3300 +6.5 +110 +2.5 -106 +3.5 -114 +4.0 -110
MIN Vikings -3.0 -105 -6.5 -120 -4.5 -10000 -6.5 -141 -2.5 -115 -3.5 -115 -4.0 -105
Sun (11/27) @ 1:00pm ET TB Buccaneers -3.0 -110 -6.5 -250 -7.5 +170 -6.5 -200 -3.5 -108 -8.5 -114 -7.0 -175
CLE Browns +3.0 -110 +6.5 +200 +7.5 -227 +6.5 +165 +3.5 -114 +8.5 -114 +7.0 +145
Sun (11/27) @ 1:00pm ET ATL Falcons +3.0 -105 +5.5 +160 +5.5 +240 +5.5 +105 +3.5 -108 +6.5 -179 +6.0 -130
WAS Commanders -3.0 -115 -5.5 -196 -5.5 -345 -5.5 -135 -3.5 -114 -6.5 +136 -6.0 +110
Sun (11/27) @ 1:02pm ET CIN Bengals -1.5 -105 -3.5 +125 -4.5 -145 -4.5 +210 -3.5 -278 -4.0 +140
TEN Titans +1.5 -115 +3.5 -154 +4.5 +110 +4.5 -263 +3.5 +205 +4.0 -169
Sun (11/27) @ 1:02pm ET DEN Broncos -2.5 -110 +12.5 +1500 +13.5 -370 +13.0 +450 +13.5 -455 +13.5 -370
CAR Panthers +2.5 -110 -12.5 -5000 -13.5 +270 -13.0 -667 -13.5 +305 -13.5 +300
Sun (11/27) @ 1:02pm ET CHI Bears +5.5 -110 +20.5 +440 +20.5 +250 +21.5 -556 +14.5 -110 +21.0 +130
NY Jets -5.5 -110 -20.5 -625 -20.5 -345 -21.5 +400 -14.5 -118 -21.0 -149
Sun (11/27) @ 1:03pm ET HOU Texans +11.5 -110 +14.5 +200 +14.5 +950 +11.5 +195 +14.5 +150 +15.0 -303
MIA Dolphins -11.5 -110 -14.5 -250 -14.5 -2500 -11.5 -238 -14.5 -196 -15.0 +240
Sun (11/27) @ 1:27pm ET BAL Ravens -3.5 -110 -8.5 -105 -7.5 -110 -5.5 -141 -3.5 -106 -6.5 +110 +0.5 +100
JAX Jaguars +3.5 -110 +8.5 -125 +7.5 -120 +5.5 +110 +3.5 -115 +6.5 -145 -0.5 -115
Sun (11/27) @ 4:04pm ET LV Raiders +3.5 -105 +3.5 -130 +6.5 +150 +3.5 -149 +4.0 -112 +6.5 +168 +1.5 0
SEA Seahawks -3.5 -115 -3.5 +100 -6.5 -200 -3.5 +120 -4.0 -109 -6.5 -227 -1.5 0
Sun (11/27) @ 4:05pm ET LA Chargers -3.0 +100 +6.5 -125 +7.5 -175 -1.0 +225 -2.5 -118 +7.5 -161 +7.5 0
ARI Cardinals +3.0 -120 -6.5 -105 -7.5 +135 +1.0 -278 +2.5 -105 -7.5 +122 -7.5 0
Sun (11/27) @ 4:24pm ET NO Saints +8.5 -115 +12.5 +350 +13.5 -10000 +13.0 +300 +9.0 -112 +13.5 -400 +13.0 -208
SF 49ers -8.5 -105 -12.5 -476 -13.5 +3300 -13.0 -400 -9.0 -109 -13.5 +275 -13.0 +175
Sun (11/27) @ 4:25pm ET LA Rams +14.5 -110 +15.5 +1000 +15.5 +1100 +16.0 -714 +16.5 -114 +15.5 +900 +16.0 0
KC Chiefs -14.5 -110 -15.5 -2000 -15.5 -5000 -16.0 +475 -16.5 -108 -15.5 -2500 -16.0 0
Sun (11/27) @ 8:22pm ET GB Packers +7.0 -105 +7.5 -149 +6.5 +190 +7.0 +340 +14.5 -147 +9.0 -108
PHI Eagles -7.0 -115 -7.5 +120 -6.5 -250 -7.0 -455 -14.5 +112 -9.0 -108
Mon (11/28) @ 8:14pm ET PIT Steelers +2.5 -105 -2.5 +105 -6.5 -345 -6.5 -278 +2.5 -109 -6.5 -357 -7.0 +165
IND Colts -2.5 -115 +2.5 -135 +6.5 +250 +6.5 +225 -2.5 -112 +6.5 +255 +7.0 -200
Thu (11/24) @ 12:34pm ET BUF Bills o52.5 -110 o53.5 +490 o50.5 -105 o49.5 -120 o47.5 +105
DET Lions u52.5 -110 u53.5 -714 u50.5 -120 u49.5 -108 u47.5 -120
Thu (11/24) @ 4:35pm ET NY Giants u43.5 -110 u47.5 -135 u47.5 +145 u47.5 -125 u43.5 +105
DAL Cowboys o43.5 -110 o47.5 +105 o47.5 -189 o47.5 -104 o43.5 -120
Thu (11/24) @ 8:23pm ET NE Patriots u42.5 -110 u68.5 -105 u68.5 -115 u42.0 -110 u67.5 -102 u66 -108
MIN Vikings o42.5 -110 o68.5 -125 o68.5 -115 o42.0 -110 o67.5 -128 o66 -108
Sun (11/27) @ 1:00pm ET TB Buccaneers u44.5 -115 u32.5 -115 u30.5 -125 u42 -110 u42.0 -109 u33.5 +102 u30.5 -108
CLE Browns o44.5 -105 o32.5 -115 o30.5 -105 o42 -110 o42.0 -112 o33.5 -132 o30.5 -108
Sun (11/27) @ 1:00pm ET ATL Falcons o42.5 -115 o35.5 +105 o33.5 -110 o40 -110 o40.5 -108 o37.5 -147 o34.5 -115
WAS Commanders u42.5 -105 u35.5 -135 u33.5 -120 u40 -110 u40.5 -114 u37.5 +112 u34.5 +100
Sun (11/27) @ 1:02pm ET CIN Bengals o42.5 -115 o39.5 +110 o38.5 -145 o36.5 -114 o38.5 -115
TEN Titans u42.5 -105 u39.5 -141 u38.5 +115 u36.5 -114 u38.5 +100
Sun (11/27) @ 1:02pm ET DEN Broncos u34.5 -105 u33.5 -286 u32.5 +165 u29.5 +100 u33.5 -278
CAR Panthers o34.5 -115 o33.5 +225 o32.5 -227 o29.5 -130 o33.5 +230
Sun (11/27) @ 1:02pm ET CHI Bears o43 -110 o46.5 -120 o47.5 -125 o47.5 -132 o41.5 +350
NY Jets u43 -110 u46.5 -110 u47.5 -105 u47.5 +102 u41.5 -455
Sun (11/27) @ 1:03pm ET HOU Texans o45.5 -110 o49.5 +130 o45.5 +775 o49.5 -110 o48.5 +100
MIA Dolphins u45.5 -110 u49.5 -161 u45.5 -1429 u49.5 -118 u48.5 -115
Sun (11/27) @ 1:27pm ET BAL Ravens o45.5 -110 o36.5 -110 o36.5 +110 o43.0 -114 o38.5 -141 o42 -130
JAX Jaguars u45.5 -110 u36.5 -120 u36.5 -135 u43.0 -108 u38.5 +108 u42 +110
Sun (11/27) @ 4:04pm ET LV Raiders o47.5 -110 o63.5 -110 o65.5 -120 o47.5 -109 o61.5 +108 o71 0
SEA Seahawks u47.5 -110 u63.5 -120 u65.5 -105 u47.5 -112 u61.5 -141 u71 0
Sun (11/27) @ 4:05pm ET LA Chargers u47.5 -110 u53.5 +100 u49.5 -110 u48.5 -109 u50.5 -114 u50.5 0
ARI Cardinals o47.5 -110 o53.5 -130 o49.5 -120 o48.5 -112 o50.5 -115 o50.5 0
Sun (11/27) @ 4:24pm ET NO Saints o42.5 -105 o20.5 +105 o19.5 -120 o43.5 -110 o43.5 -112 o20.5 +122 o13.5 +120
SF 49ers u42.5 -115 u20.5 -135 u19.5 +100 u43.5 -110 u43.5 -109 u20.5 -161 u13.5 -141
Sun (11/27) @ 4:25pm ET LA Rams u44 -110 u39.5 -110 u36.5 -110 u41.5 -112 u40.5 -141 u37.5 0
KC Chiefs o44 -110 o39.5 -120 o36.5 -115 o41.5 -109 o40.5 +108 o37.5 0
Sun (11/27) @ 8:22pm ET GB Packers o45.5 -110 o72.5 -125 o71.5 -130 o67.5 +142 o73.5 -125
PHI Eagles u45.5 -110 u72.5 -105 u71.5 +100 u67.5 -189 u73.5 +110
Mon (11/28) @ 8:14pm ET PIT Steelers u39.5 -110 u43.5 -115 u44.5 -110 u39.5 -110 u39.5 -110 u44.5 -115 u44 -108
IND Colts o39.5 -110 o43.5 -115 o44.5 -110 o39.5 -110 o39.5 -110 o44.5 -114 o44 -108

Here’s a game-by-game look at Week 12 betting lines, which opened at DraftKings on Nov. 20.

Thanksgiving Day Games

Bills (-9.5, 54) vs. Lions

The Lions have now won and covered three straight games heading into their Turkey Day matchup with the Bills. This is the biggest total on the Week 12 slate. Detroit has gone 5-1 to the Over in its last six home games.

The Buffalo Bills are our NFL Week 5 Survivor Pick
The Bills are laying a big number vs. the Lions, per NFL Week 12 betting odds. (AP Photo/Adrian Kraus)

Giants vs. Cowboys (-8.5, 44.5)

New York will try to avenge its 23-16 home loss to the Cowboys in Week 3. The Cowboys have won five straight games against the Giants, and 10 of the last 11 in the series.

Patriots vs. Vikings (-3, 41.5)

The Vikings were the talk of the NFL after their big win at Buffalo. Dallas brought Minnesota back to earth with a 40-3 beatdown yesterday. The Patriots are riding a 6-1 streak of covering ATS.

Actionable advice: MNF Player Props for 49ers-Cardinals in Mexico City

Sunday’s Games

Broncos (-2.5, 35) vs. Panthers

Lowest total on the Week 12 betting board here. These two teams rarely play each other. Denver is 6-1 ATS vs. Carolina including a 24-10 victory in the Super Bowl back in 2016.

Bucs (-3, 44) vs. Browns

Have the Bucs actually righted the ship? We’ll find out more in this matchup against the Browns coming off a bye week. Tampa Bay rushed for a season-best 161 yards in its 21-16 win over Seattle in Germany. The only other time the Bucs eclipsed more than 100 yards on the ground came in the season-opening 19-3 win at Dallas.

Ravens (-4, 45.5) vs. Jaguars

The Ravens have been road warriors with a 4-1 ATS record this season through Week 10. Consider a bet on the Under here. Baltimore has cashed it in six of its last seven games, and Jacksonville’s last five home games have gone Under.

Texans vs. Dolphins (-12, 46)

AFC East leader Miami (7-3) has won all seven games that QB Tua Tagovailoa started and finished. The Dolphins are coming off a bye to face Houston, which is in line for the No. 1 pick in the draft at 1-8-1.

Bears vs. Jets (-4, 44)

The Jets are bidding to make their first appearance in the playoffs since 2010. DraftKings was dealing the Jets at +120 to make the playoffs and -145 to miss the postseason as of this update.

Bengals (-1.5, 43) vs. Titans

The Bengals did not place WR Ja’Marr Chase on injured reserve after his hip injury. He would have missed this game on IR, but Chase could be back for this crucial contest.

Bet NFL totals at BetMGM: Use Bonus Code TODAY for $1,000 Risk-Free Bet

Falcons vs. Commanders (-3.5, 43)

Taylor Heinicke is now 4-1 after taking over for Carson Wentz. He’s officially QB1 for the Commanders now. Washington has been a boon for bettors recently going 5-0-1 ATS in its last six tilts.

Chargers (-3, 47.5) vs. Cardinals

The Chargers have been making bettors mucho dinero in road games this year. LA is 5-0 in road tilts.

Raiders vs. Seahawks (-4, 47)

Seattle will be coming off a bye after its 21-16 loss to Tampa Bay in Germany. The 12th man has helped the Seahawks to a 3-1 home record and ATS this season.

Rams vs. Chiefs (-14, 44)

Here’s the biggest spread on the Week 12 betting board. WR Cooper Kupp (ankle) is on injured reserve and will miss this game. The Rams really could have used him in an effort to keep up with Patrick Mahomes & Co. The Chiefs lead the NFL in scoring with 30 points per game.

Saints vs. 49ers (-8, 42)

This seems like a big number, but San Francisco’s top-rated defense has helped it go 2-1 in the role of home favorite this season. The 49ers (+700) are now the fourth betting favorite to win Super Bowl 57 at DraftKings.

Packers vs. Eagles (-6.5, 45)

Philadelphia was also a 6.5-point favorite on the road at Indy yesterday. The Eagles escaped with a 1-point win after Jalen Hurts scampered for a late TD. Aside from Christian Watson scoring five TDs in Green Bay’s last two games, there’s not a lot of positivity around the Packers these days.

Monday Night Football

Steelers vs. Colts (-3, 39.5)

Fun fact: Indy had lost three straight games and failed to cover in all of them before Jeff Saturday took over as head coach. Despite yesterday’s 17-16 loss to the Eagles, the Colts are now 2-0 ATS with Saturday at the helm.

Also read: Discover the best sportsbook promos and bonuses | How to bet on NFL | Super Bowl 57 odds for all teams

About the Author
Kris Johnson

Kris Johnson

Writer & Contributor
Kris Johnson is a Senior Writer at Gaming Today with more than 15 years of experience as a sports journalist. Kris' work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and more. Kris also authored a sports betting novel entitled The Endgame.

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