NFL Week 13 Odds, Picks, Schedule: 49ers-Eagles, Chiefs-Packers Highlight Strong Slate is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. Gaming Today may receive referral compensation from the sportsbook company when you claim a bonus offer or promotion through a link on this site. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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Week 13 in the NFL offers plenty to watch as the battle to secure playoff spots heats up. Six teams have a Week 13 bye — the Bills, Bears, Raiders, Vikings, Giants, and Ravens — but the 13 games on tap include an intriguing Thursday Night Football battle between the Seahawks and Cowboys.

Sunday’s top matchups include 49ers-Eagles and Chiefs-Packers on Sunday Night Football, followed by Bengals-Jaguars to wrap up the week on Monday, Dec. 4.

We recommend the best NFL betting sites in Gaming Today’s overview of the odds for the best games of Week 13. Let’s break down the best NFL Week 13 odds and analyze a few of the best matchups here.

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Seattle Seahawks (6-5) at Dallas Cowboys (8-3)

  • Time: Thursday, 8:15 p.m. ET
  • TV/Live Stream: Prime Video


The Cowboys once again made it clear in Week 12 that there’s a massive gap between them and the league’s bad teams, blowing out Washington 45-10 on Thanksgiving. But Dallas has not looked nearly as impressive against the top teams, losing to both San Francisco and Philadelphia. On paper, the Seahawks pose a much bigger challenge than the Cowboys’ last three opponents (the Giants, Panthers, and Commanders), but they have lost three of their last four games and do not look like the same team that started the year 5-2.

Seattle is coming off an 18-point loss at home to San Francisco last week in a game they trailed 24-3 at halftime, and it’s not hard to imagine a similar result for Pete Carroll’s team in Dallas on Thursday night.

Pick: Dallas (-7.5 at time of publishing)

Denver Broncos (6-5) at Houston Texans (6-5)

  • Time: Sunday, 1:00 p.m. ET
  • TV/Live Stream: CBS


Despite the Texans’ close loss to division rival Jacksonville on Sunday, these are two of the hottest teams in the league. Neither were considered playoff contenders in August, or even as recently as mid-October, but Denver is now in the thick of the Wild Card hunt at 6-5 after winning five games in a row. Houston is also playing well after struggling early this year, with four wins over the last six weeks, including three of its last four.

Turnovers have played a massive role in the Broncos’ winning streak (they’ve forced at least three turnovers in each of their last four games), and Russell Wilson has been solid, with just two picks in his team’s last eight games.

Expect Denver to keep this one close, and low-scoring, making the Under the best play.

Pick: Under (46.5 at time of publishing)

San Francisco 49ers (8-3) at Philadelphia Eagles (10-1)

  • Time: Sunday, 4:25 p.m. ET
  • TV/Live Stream: FOX


San Francisco’s trip to Philadelphia marks the biggest game of the weekend. This looks like a preview of the NFC Championship Game, and it’s crucial for the Niners’ slim hopes of home-field advantage. A 49ers win would cut the Eagles’ lead in the fight for the No. 1 seed to just one game with five left on the schedule. But a Philadelphia win would give it a three-game lead and all but guarantee that the road to the Super Bowl in this conference would go through Lincoln Financial Field.

While the Niners have looked outstanding the last couple of weeks and the Eagles have shown some vulnerabilities, it feels like a no-brainer to take a team as good as Philly is at finding a way to win as the home underdog. The Eagles are coming off two straight tough wins against the Chiefs and Bills, but as long as they can keep this game close, how can you bet against Jalen Hurts if he has a chance in the fourth quarter?

Pick: Eagles moneyline (+126 at time of publishing)

Kansas City Chiefs (8-3) at Green Bay Packers (5-6)

  • Time: Sunday, 8:20 p.m. ET
  • TV/Live Stream: NBC


The Chiefs responded to a brutal Week 11 loss to Philadelphia on Monday Night Football with a 14-point win over the Raiders, while Green Bay stunned Detroit on the road on Thanksgiving Day last week. The Packers look like a dangerous home dog for a couple of reasons: they’ve won three of their last four, QB Jordan Love has shown signs in recent weeks that he’s the Packers’ QB of the future, and this team is rested coming off an early Thursday game in Week 12.

But the Chiefs have one of the best defenses Love will have faced this season, and Patrick Mahomes may have finally found a receiver he can trust (besides Travis Kelce). Last Sunday against Las Vegas, Mahomes completed eight passes to rookie WR Rashee Rice for 107 yards and a TD. Given how well the KC D has played this year, Rice’s emergence could be enough for the Chiefs to stay atop the AFC.

At home, Green Bay covering feels like a safe bet.

Pick: Green Bay (+6.5 at time of publishing)

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About the Author
Tyler Everett

Tyler Everett

Tyler Everett has been a sports writer since joining the student newspaper at his alma mater, NC State, back in 2008. He's covered sports and sports business for a number of newspapers and websites, including the Denver Broncos, Charlotte Observer, High Press Soccer, and Sports Business Journal, where he currently works full-time.

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