It’s time to check on NFL Week 15 odds and see how betting lines have moved for the full slate.
This marks the first week of the season when games will be played on Thursday, Saturday, Sunday, and Monday. The 49ers beat the Seahawks, 21-13, to start the week on TNF.
Dolphins-Bills highlights a trio of games on Saturday, Dec. 17.
Let’s take a look at NFL Week 15 odds.
DraftKings Sportsbook
Claim $50 Free Bet, $1,000 Deposit Match BonusGrab a $50 free bet and a 20% deposit match up to $1,000 at DraftKings Sportsbook by clicking here.
NFL Week 15 Betting Lines
Here’s are a look at odds for Week 15 games from the best sports betting apps.
NFL Week 15 Odds
Here’s a game-by-game peek at NFL Week 15 betting lines from DraftKings:
Saturday, December 17
Colts at Vikings (-3.5, 47.5)
Some support for Indianapolis here after Minnesota opened at -5. The Vikings can clinch the NFC North with a win over the Colts or a loss by the Lions.
Ravens at Browns (-3, 38)
Lamar Jackson (knee) is out again for the Ravens. Baltimore’s defense has been up to the task lately, giving up an average of just 13. 7 points in their last four games. Baltimore (9-4) is currently tied with Cincinnati atop the AFC North.
Dolphins at Bills (-7, 44)
Miami’s Tyreek Hill (ankle) was a full participant in practice on Wednesday and Thursday, but RB Jeff Wilson Jr. (hip) is questionable heading into this huge AFC East matchup.

Miami will be playing its third consecutive road game after losses to the 49ers and Chargers. The Dolphins beat the Bills, 21-19, in Week 3.
Miami is 1-4 ATS as a road dog this season.
Sunday, December 18
Eagles (-9, 48.5) at Bears
Philly backers have bet this up a full three points after the Eagles opened at -6. The Eagles clinched a playoff berth for the fourth time in the last five years with a win against the Giants in Week 14. The Bears (3-10) are officially out of playoff contention.
Cowboys (-4, 48) at Jaguars
Jacksonville took some money during the week after Dallas opened at -6. Interesting trend on the total here: Dallas and Jacksonville have played to the Over the last five times they’ve met. Dallas has won six of its last seven games SU.
Falcons at Saints (-4, 43.5)
The Saints have owned the Falcons, winning five of the last six games in the series. Both teams have been playing to the Under of late.
Lions at Jets (-2, 44.5)
Detroit is 5-0 ATS in its last five games and 5-1 SU in its last six. The Over is 4-1 in the last five games between the Lions and Jets, but bettors favor the Under here after the total opened at 48.
Bengals (-3.5, 44.5) at Bucs
Tampa Bay got exposed in last week’s 35-7 loss at San Francisco. The Bucs have yet to cover at Raymond James Stadium this season. They are 0-5-1 ATS at home.
Titans at Chargers (-3, 46.5)
Tennessee is 5-1 ATS in its last six road games. The Chargers have won their last five games SU against the Titans when playing at home.
Giants at Commanders (-4.5, 40.5)
If it feels like these two teams played fairly recently, it’s because they did. This will be a rematch of the 20-20 tie in Week 13. Washington is 6-1-1 ATS in its last eight games.
Monday, December 19
Rams at Packers (-7, 39.5)
San Francisco’s win over Seattle on TNF helped Green Bay’s slim playoff chances. This looked like a gem of a MNF game at the beginning of the season. The defending Super Bowl champions taking on a perennial playoff team with so much on the line to end Week 15. Unfortunately, for ESPN anyway, this doesn’t qualify as appointment viewing anymore — unless you gamble on it!
The Rest of NFL Week 15 Games
Chiefs (-14, 49.5) at Texans
Steelers at Panthers (-2.5, 37.5)
Cardinals at Broncos (-3, 37)
Patriots at Raiders (-1, 44.5)
Also read: Super Bowl 57 Odds