NFL Week 16 odds are up at DraftKings, and the 16-game slate is highlighted by an NFC East showdown between the Philadelphia Eagles and Dallas Cowboys.
Dallas is being dealt at -1 with a total of 51.5. The Eagles (13-1 straight up, 8-6 against the spread) have locked up a playoff berth. The Cowboys (10-4 SU, 8-6 against the spread) look to avenge a 26-17 loss at Philadelphia in Week 6.
Let’s take a look NFL Week 16 odds, with the majority of games being played on Saturday, Dec. 24, before a Christmas Day tripleheader.
DraftKings Sportsbook
Claim $50 Free Bet, $1,000 Deposit Match BonusGrab a $50 free bet and a 20% deposit match up to $1,000 at DraftKings Sportsbook by clicking here.
NFL Week 16 Betting Lines
Here are odds for Week 16 games from the best sports betting apps.
NFL Week 16 Odds
Here’s a game-by-game peek at NFL Week 16 betting lines from DraftKings:
Jaguars at Jets (-1, 39.5) — TNF
The Jets have been favored at home only once this season. They covered as an 8.5-point favorite in a 31-10 win over Chicago in Week 12. Jacksonville is 2-5 SU on the road this year.
Saturday, Dec. 24
Seahawks at Chiefs (-10, 49.5)
Kansas City slept-walked through much of yesterday’s 30-24 OT win at Houston, but the day ended with the Chiefs securing their seventh straight AFC West division title.
KC has been costing its backers in home games, going 1-5 ATS at Arrowhead Stadium. The Chiefs have also failed to cover the number in their last five games.
Bills (-9, 41) at Bears
For all their success this year, the Bills have still managed to cover once in their last eight games. The Bears played the Eagles tough yesterday and covered in a 25-20 loss at home.
Eagles at Cowboys (-1, 51.5)
Week 16’s marquee matchup sees Philadelphia traveling to Dallas for this NFC East grudge match. The Cowboys are coming off a 40-34 OT loss at Jacksonville.

The Eagles are only 2-5 ATS in road tilts this season. The Cowboys are 5-3 ATS at home.
Bengals (-3.5, 40) at Patriots
The Bengals (10-4) are jockeying with the Ravens (9-5) for the AFC North title. The Patriots (7-7) remain in playoff contention, but their last three games are against the Bengals, Dolphins, and Bills — arguably the toughest stretch on their schedule.
Lions (-3, 44.5) at Panthers
The Lions (7-7) have clawed their way back from a 1-6 start to the season. They likely need to go 3-0 down the stretch to make the playoffs. Carolina (5-9) somehow remains in playoff contention in the putrid NFC South.
Falcons at Ravens (-7, 40)
Baltimore needs to get QB Lamar Jackson (knee) back for this contest. The Ravens looked anemic in Saturday’s 13-3 loss at Cleveland. Baltimore faced a similar scenario last year when it lost Jackson after starting 8-3. The Ravens lost their last six games and missed the playoffs.
Giants at Vikings (-3.5, 47.5)
It took the greatest comeback in NFL history, but the Vikings (11-3) clinched the NFC North after their 39-36 OT win over the Colts. Minnesota failed to cover as a 4-point favorite.
Check out: NFL Week 15 Betting Tips
Sunday, Dec. 25
Packers at Dolphins (-4, 46.5)
Miami has now dropped three straight games. The Dolphins (8-6) are suddenly three games behind Buffalo in the AFC East after dropping a 32-29 decision to the Bills on Saturday.
Broncos (-1.5, 35.5) at Rams
The who cares game of the week. The Broncos are an astounding 11-3 to the Under this year.
Bucs (-4, 40.5) at Cardinals
Tampa Bay (6-8) is still somehow clinging to a one-game lead in the NFC South. After yesterday’s 34-23 loss to the Bengals, the Bucs have still yet to cover ATS at home this season at 0-6-1.
Chargers (-3.5, 47.5) at Colts — MNF
The Chargers pulled out a 17-14 win against Tennessee and pushed as a three-point favorite on Sunday. LA has been a solid bet on the road this year, going 5-2 ATS in away games.
The Rest of NFL Week 16 Games
Saints at Browns (-3, 34.5)
Texans at Titans (-7, 39)
Commanders at 49ers (-7, 40.5)
Raiders at Steelers (-2, 40.5)
Also read: Super Bowl 57 odds | 2022 NFL MVP odds