NFL Week 16 Odds: Cowboys a Slight Home Favorite vs. Eagles

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NFL Week 16 odds are up at DraftKings, and the 16-game slate is highlighted by an NFC East showdown between the Philadelphia Eagles and Dallas Cowboys.

Dallas is being dealt at -1 with a total of 51.5. The Eagles (13-1 straight up, 8-6 against the spread) have locked up a playoff berth. The Cowboys (10-4 SU, 8-6 against the spread) look to avenge a 26-17 loss at Philadelphia in Week 6.

Let’s take a look NFL Week 16 odds, with the majority of games being played on Saturday, Dec. 24, before a Christmas Day tripleheader.

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NFL Week 16 Betting Lines

Here are odds for Week 16 games from the best sports betting apps.

Bet TypeSpreads
Open
Thu (12/21) @ 8:16pm ET NO Saints +165 +2500 +1850 +6000 +160 +3000 +1300
LA Rams -200 -10000 -10000 0 -200 0 -10000
Sat (12/23) @ 4:31pm ET CIN Bengals -141 +4000 +3300 +2500 -152 +1100 +2500
PIT Steelers +115 0 -10000 -10000 +125 -5000 -10000
Sat (12/23) @ 8:05pm ET BUF Bills -909 0 -1429 -1250 -1429 -1429
LA Chargers +600 +4000 +700 +670 +680 +700
Sun (12/24) @ 1:01pm ET IND Colts -125 +1800 +3300 +1200 +132 +1500 +8000
ATL Falcons +105 -5000 -10000 -5000 -159 -10000 0
Sun (12/24) @ 1:01pm ET DET Lions -185 -200 -400 -500 -147 -370 0
MIN Vikings +150 +154 +300 +350 +120 +265 0
Sun (12/24) @ 1:01pm ET SEA Seahawks -145 -2000 -3333 -345 -159 -1667 -1429
TEN Titans +120 +1000 +1050 +260 +132 +800 +850
Sun (12/24) @ 1:02pm ET WAS Commanders +135 -244 +110 +115 +132 +132 +160
NY Jets -161 +185 -145 -145 -159 -169 -227
Sun (12/24) @ 1:04pm ET CLE Browns +115 0 -10000 -3333 -10000 0
HOU Texans -141 +4000 +3300 +1100 +1700 +10000
Sun (12/24) @ 1:05pm ET GB Packers -208 -1111 -2000 -10000 -196 -5000 -1250
CAR Panthers +170 +650 +900 +2200 +160 +1400 +700
Sun (12/24) @ 4:06pm ET JAX Jaguars -135 +4000 +3300 +850 -128 +1300 +4000
TB Buccaneers +110 0 -10000 -1667 +104 -5000 0
Sun (12/24) @ 4:26pm ET ARI Cardinals +165 +2000 +3300 +900 +170 +3000 +9000
CHI Bears -200 -10000 -10000 -2000 -208 0 0
Sun (12/24) @ 4:26pm ET DAL Cowboys +105 +1800 +1400 +1800 +108 +2500 +1300
MIA Dolphins -125 -5000 -10000 -5000 -133 0 -3333
Sun (12/24) @ 8:17pm ET NE Patriots +200 0 -714 0 +265 0 0
DEN Broncos -250 +4000 +475 +3500 -345 +5500 0
Mon (12/25) @ 1:05pm ET LV Raiders +375 -3333 -10000 -10000 +425 0 -5000
KC Chiefs -500 +1400 +1500 +2200 -588 +2500 +1400
Mon (12/25) @ 4:35pm ET NY Giants +400 +2500 +1200 +1400 +1400 +2500
PHI Eagles -556 -10000 -5000 -5000 -5000 0
Mon (12/25) @ 8:16pm ET BAL Ravens +180 -5000 -10000 -2000 +230 0 -10000
SF 49ers -227 +1500 +1300 +900 -294 +3500 +1500
Thu (12/21) @ 8:16pm ET NO Saints +19.5 -115 +8.5 -526 +16.5 -227 +8.5 -238 +4.0 -110 +7.5 +500 +8.5 0
LA Rams -19.5 -115 -8.5 +360 -16.5 +165 -8.5 +185 -4.0 -110 -7.5 -909 -8.5 0
Sat (12/23) @ 4:31pm ET CIN Bengals +16.5 -115 +22.5 +290 +22.5 +300 +22.5 +320 -2.5 -114 +22.5 +415 +22.5 +230
PIT Steelers -16.5 -115 -22.5 -417 -22.5 -455 -22.5 -455 +2.5 -108 -22.5 -667 -22.5 -303
Sat (12/23) @ 8:05pm ET BUF Bills -13.5 -110 -2.5 +165 -2.5 +160 -4.5 -141 -4.5 -189 -2.0 0
LA Chargers +13.5 -110 +2.5 -213 +2.5 -208 +4.5 +110 +4.5 +142 +2.0 0
Sun (12/24) @ 1:01pm ET IND Colts -2.0 -110 +18.5 +325 +18.5 +525 +18.5 +500 +2.5 -103 +18.5 +245 +19.0 0
ATL Falcons +2.0 -110 -18.5 -476 -18.5 -1000 -18.5 -833 -2.5 -120 -18.5 -345 -19.0 0
Sun (12/24) @ 1:01pm ET DET Lions -3.0 -110 -6.5 +280 -6.5 +155 -6.5 +175 -3.0 -104 -8.5 -141 -6.5 +250
MIN Vikings +3.0 -110 +6.5 -400 +6.5 -208 +6.5 -222 +3.0 -118 +8.5 +108 +6.5 -345
Sun (12/24) @ 1:01pm ET SEA Seahawks -2.5 -110 +3.5 +260 -2.5 -2500 -2.5 -161 -3.0 -110 +3.5 +265 +4.0 0
TEN Titans +2.5 -110 -3.5 -357 +2.5 +825 +2.5 +125 +3.0 -110 -3.5 -385 -4.0 0
Sun (12/24) @ 1:02pm ET WAS Commanders +3.0 -110 +1.5 -105 +1.5 -115 +6.5 -189 +3.0 -118 +5.5 +165 -1.0 -105
NY Jets -3.0 -110 -1.5 -125 -1.5 -110 -6.5 +150 -3.0 -104 -5.5 -222 +1.0 -120
Sun (12/24) @ 1:02pm ET CLE Browns +2.5 -110 -11.5 -1111 -13.5 -1000 -15.0 +5000 -13.5 -909 -14.0 -149
HOU Texans -2.5 -110 +11.5 +650 +13.5 +550 +15.0 0 +13.5 +530 +14.0 +120
Sun (12/24) @ 1:05pm ET GB Packers -4.0 -110 -2.5 -370 -7.5 +155 -8.5 +180 -3.5 -112 -8.5 +175 -7.5 -175
CAR Panthers +4.0 -110 +2.5 +270 +7.5 -208 +8.5 -233 +3.5 -109 +8.5 -233 +7.5 +140
Sun (12/24) @ 4:06pm ET JAX Jaguars -2.0 -110 +18.5 -189 +18.5 -189 +18.0 +2500 -2.0 -110 +17.5 +320 +18.5 0
TB Buccaneers +2.0 -110 -18.5 +145 -18.5 +145 -18.0 -10000 +2.0 -110 -17.5 -476 -18.5 0
Sun (12/24) @ 4:26pm ET ARI Cardinals +4.5 -110 +10.5 +400 +10.5 +170 +10.5 +1100 +5.0 -118 +10.5 +325 +10.5 +120
CHI Bears -4.5 -110 -10.5 -625 -10.5 -227 -10.5 -3333 -5.0 -104 -10.5 -476 -10.5 -149
Sun (12/24) @ 4:26pm ET DAL Cowboys +1.5 -110 +2.5 +100 +2.5 -1429 +4.5 -115 +1.0 -106 +5.5 -108 +5.5 -120
MIA Dolphins -1.5 -110 -2.5 -130 -2.5 +650 -4.5 -115 -1.0 -115 -5.5 -120 -5.5 -105
Sun (12/24) @ 8:17pm ET NE Patriots +5.5 -110 -2.5 -120 -6.5 -141 -4.5 -125 +7.0 -104 -5.5 +102 -4.5 -120
DEN Broncos -5.5 -110 +2.5 -110 +6.5 +105 +4.5 -105 -7.0 -118 +5.5 -132 +4.5 -105
Mon (12/25) @ 1:05pm ET LV Raiders +10.0 -110 -6.5 +170 -6.5 +170 -12.5 -141 +11.0 -110 -11.5 -114 -10.0 -112
KC Chiefs -10.0 -110 +6.5 -222 +6.5 -227 +12.5 +110 -11.0 -110 +11.5 -114 +10.0 -112
Mon (12/25) @ 4:35pm ET NY Giants +10.5 -110 +12.5 -278 +11.5 +185 +12.5 -263 +11.5 +235 +11.5 +135
PHI Eagles -10.5 -110 -12.5 +210 -11.5 -250 -12.5 +200 -11.5 -333 -11.5 -169
Mon (12/25) @ 8:16pm ET BAL Ravens +5.0 -110 -12.5 -115 -7.5 +160 -7.5 +230 +6.5 -110 -9.5 -130 -10.5 -112
SF 49ers -5.0 -110 +12.5 -115 +7.5 -227 +7.5 -303 -6.5 -110 +9.5 +100 +10.5 -112
Thu (12/21) @ 8:16pm ET NO Saints u44.5 -110 u52.5 -200 u46.5 +105 u45.5 -110 u45.5 -114 u46.5 +100 u47.5 0
LA Rams o44.5 -110 o52.5 +154 o46.5 -141 o45.5 -110 o45.5 -108 o46.5 -130 o47.5 0
Sat (12/23) @ 4:31pm ET CIN Bengals o38.5 -110 o47.5 -135 o45.5 +400 o39.5 -110 o39.0 -109 o50.5 -122 o45.5 +220
PIT Steelers u38.5 -110 u47.5 +105 u45.5 -667 u39.5 -110 u39.0 -112 u50.5 -106 u45.5 -294
Sat (12/23) @ 8:05pm ET BUF Bills o42.5 -110 o44.5 -120 o44.5 +110 o43.5 -141 o48.5 0
LA Chargers u42.5 -110 u44.5 -110 u44.5 -145 u43.5 +108 u48.5 0
Sun (12/24) @ 1:01pm ET IND Colts u44.5 -115 u39.5 -125 u41.5 -110 u44 -110 u44.5 -110 u39.5 +126 u42.5 0
ATL Falcons o44.5 -105 o39.5 -105 o41.5 -120 o44 -110 o44.5 -110 o39.5 -164 o42.5 0
Sun (12/24) @ 1:01pm ET DET Lions o46.5 -115 o54.5 +170 o57.5 -145 o48 -110 o47.5 -112 o57.5 -132 o54.5 +165
MIN Vikings u46.5 -105 u54.5 -222 u57.5 +110 u48 -110 u47.5 -109 u57.5 +102 u54.5 -208
Sun (12/24) @ 1:01pm ET SEA Seahawks o42.5 -110 o30.5 -110 o39.5 +475 o42.5 -110 o42.0 -109 o32.5 -130 o30.5 0
TEN Titans u42.5 -110 u30.5 -120 u39.5 -833 u42.5 -110 u42.0 -112 u32.5 +100 u30.5 0
Sun (12/24) @ 1:02pm ET WAS Commanders u37.5 -105 u54.5 -125 u57.5 -105 u36 -110 u36.5 -109 u57.5 +108 u57.5 +120
NY Jets o37.5 -115 o54.5 -105 o57.5 -125 o36 -110 o36.5 -112 o57.5 -141 o57.5 -149
Sun (12/24) @ 1:05pm ET GB Packers u36.5 -110 u63.5 -208 u56.5 -125 u39.5 -110 u39.5 -110 u55.5 -139 u55.5 -130
CAR Panthers o36.5 -110 o63.5 +160 o56.5 -105 o39.5 -110 o39.5 -110 o55.5 +106 o55.5 +105
Sun (12/24) @ 4:06pm ET JAX Jaguars o45 -110 o42.5 +100 o41.5 -145 o43 -110 o43.5 -108 o43.5 -102 o44.5 0
TB Buccaneers u45 -110 u42.5 -130 u41.5 +110 u43 -110 u43.5 -114 u43.5 -128 u44.5 0
Sun (12/24) @ 4:26pm ET ARI Cardinals o44.5 -110 o40.5 -141 o40.5 -164 o42 -110 o42.5 -108 o41.5 +134 o43 0
CHI Bears u44.5 -110 u40.5 +110 u40.5 +125 u42 -110 u42.5 -114 u41.5 -175 u43 0
Sun (12/24) @ 4:26pm ET DAL Cowboys o51 -110 o41.5 -141 o42.5 +625 o48.5 -110 o48.5 -112 o39.5 -102 o40.5 -112
MIA Dolphins u51 -110 u41.5 +110 u42.5 -1250 u48.5 -110 u48.5 -109 u39.5 -128 u40.5 -112
Sun (12/24) @ 8:17pm ET NE Patriots u36.5 -110 u49.5 -278 u40.5 -130 u37.5 -110 u37.0 -110 u43.5 -102 u44 -120
DEN Broncos o36.5 -110 o49.5 +210 o40.5 +100 o37.5 -110 o37.0 -110 o43.5 -128 o44 -105
Mon (12/25) @ 1:05pm ET LV Raiders u43 -110 u34.5 -167 u33.5 -115 u40 -110 u40.5 -112 u33.5 -106 u33.5 +100
KC Chiefs o43 -110 o34.5 +130 o33.5 -115 o40 -110 o40.5 -109 o33.5 -122 o33.5 -125
Mon (12/25) @ 4:35pm ET NY Giants o43.5 -110 o50.5 -141 o50.5 -120 o50.5 -115 o54.5 -112
PHI Eagles u43.5 -110 u50.5 +110 u50.5 -110 u50.5 -114 u54.5 -112
Mon (12/25) @ 8:16pm ET BAL Ravens o45.5 -110 o58.5 -110 o56.5 -110 o47 -110 o47.0 -112 o58.5 -147 o58.5 -141
SF 49ers u45.5 -110 u58.5 -120 u56.5 -115 u47 -110 u47.0 -109 u58.5 +112 u58.5 +110

NFL Week 16 Odds

Here’s a game-by-game peek at NFL Week 16 betting lines from DraftKings:

Jaguars at Jets (-1, 39.5) — TNF

The Jets have been favored at home only once this season. They covered as an 8.5-point favorite in a 31-10 win over Chicago in Week 12. Jacksonville is 2-5 SU on the road this year.

Saturday, Dec. 24

Seahawks at Chiefs (-10, 49.5)

Kansas City slept-walked through much of yesterday’s 30-24 OT win at Houston, but the day ended with the Chiefs securing their seventh straight AFC West division title.

KC has been costing its backers in home games, going 1-5 ATS at Arrowhead Stadium. The Chiefs have also failed to cover the number in their last five games.

Bills (-9, 41) at Bears

For all their success this year, the Bills have still managed to cover once in their last eight games. The Bears played the Eagles tough yesterday and covered in a 25-20 loss at home.

Eagles at Cowboys (-1, 51.5)

Week 16’s marquee matchup sees Philadelphia traveling to Dallas for this NFC East grudge match. The Cowboys are coming off a 40-34 OT loss at Jacksonville.

The Cowboys and QB Dak Prescott are slight favorites against the Eagles, per NFL Week 16 odds. (AP Photo/Matt Ludtke)

The Eagles are only 2-5 ATS in road tilts this season. The Cowboys are 5-3 ATS at home.

Bengals (-3.5, 40) at Patriots

The Bengals (10-4) are jockeying with the Ravens (9-5) for the AFC North title. The Patriots (7-7) remain in playoff contention, but their last three games are against the Bengals, Dolphins, and Bills — arguably the toughest stretch on their schedule.

Lions (-3, 44.5) at Panthers

The Lions (7-7) have clawed their way back from a 1-6 start to the season. They likely need to go 3-0 down the stretch to make the playoffs. Carolina (5-9) somehow remains in playoff contention in the putrid NFC South.

Falcons at Ravens (-7, 40)

Baltimore needs to get QB Lamar Jackson (knee) back for this contest. The Ravens looked anemic in Saturday’s 13-3 loss at Cleveland. Baltimore faced a similar scenario last year when it lost Jackson after starting 8-3. The Ravens lost their last six games and missed the playoffs.

Giants at Vikings (-3.5, 47.5)

It took the greatest comeback in NFL history, but the Vikings (11-3) clinched the NFC North after their 39-36 OT win over the Colts. Minnesota failed to cover as a 4-point favorite.

Check out: NFL Week 15 Betting Tips

Sunday, Dec. 25

Packers at Dolphins (-4, 46.5)

Miami has now dropped three straight games. The Dolphins (8-6) are suddenly three games behind Buffalo in the AFC East after dropping a 32-29 decision to the Bills on Saturday.

Broncos (-1.5, 35.5) at Rams

The who cares game of the week. The Broncos are an astounding 11-3 to the Under this year.

Bucs (-4, 40.5) at Cardinals

Tampa Bay (6-8) is still somehow clinging to a one-game lead in the NFC South. After yesterday’s 34-23 loss to the Bengals, the Bucs have still yet to cover ATS at home this season at 0-6-1.

Chargers (-3.5, 47.5) at Colts — MNF

The Chargers pulled out a 17-14 win against Tennessee and pushed as a three-point favorite on Sunday. LA has been a solid bet on the road this year, going 5-2 ATS in away games.

The Rest of NFL Week 16 Games

Saints at Browns (-3, 34.5)

Texans at Titans (-7, 39)

Commanders at 49ers (-7, 40.5)

Raiders at Steelers (-2, 40.5)

Also read: Super Bowl 57 odds | 2022 NFL MVP odds

About the Author
Kris Johnson

Kris Johnson

Senior Writer
Kris Johnson is a senior writer at Gaming Today with more than 15 years of experience as a sports journalist. Johnson's work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and other publications. He also authored a sports betting novel titled The Endgame.

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