NFL Week 16 Odds: Cowboys a Slight Home Favorite vs. Eagles

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NFL Week 16 odds are up at DraftKings, and the 16-game slate is highlighted by an NFC East showdown between the Philadelphia Eagles and Dallas Cowboys.

Dallas is being dealt at -1 with a total of 51.5. The Eagles (13-1 straight up, 8-6 against the spread) have locked up a playoff berth. The Cowboys (10-4 SU, 8-6 against the spread) look to avenge a 26-17 loss at Philadelphia in Week 6.

Let’s take a look NFL Week 16 odds, with the majority of games being played on Saturday, Dec. 24, before a Christmas Day tripleheader.

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NFL Week 16 Betting Lines

Here are odds for Week 16 games from the best sports betting apps.

Bet TypeSpreads
Open
Thu (12/22) @ 8:16pm ET JAX Jaguars -105 -1667 -1000 -833 -3333 -10000
NY Jets -115 +900 +550 +525 +1060 +3000
Sat (12/24) @ 1:00pm ET SEA Seahawks +350 +1700 +3300 +1400 +385 +1700 +1500
KC Chiefs -455 -10000 -10000 -5000 -476 -10000 -10000
Sat (12/24) @ 1:00pm ET NY Giants +165 +220 +3300 +210 +185 +180 -105
MIN Vikings -200 -278 -10000 -263 -213 -233 -115
Sat (12/24) @ 1:00pm ET CIN Bengals -208 -115 -10000 +155 -167 +134 +145
NE Patriots +170 -115 +3300 -189 +147 -172 -175
Sat (12/24) @ 1:02pm ET ATL Falcons +240 +2500 +2500 +900 +3500 +4000
BAL Ravens -303 0 -10000 -1667 0 0
Sat (12/24) @ 1:02pm ET NO Saints +150 -1429 -345 -5000 -588 -556
CLE Browns -185 +800 +250 +2000 +390 +400
Sat (12/24) @ 1:02pm ET BUF Bills -370 0 -10000 -1667 0 0
CHI Bears +300 +2500 +3300 +850 +3000 +4500
Sat (12/24) @ 1:02pm ET DET Lions -161 +900 +3300 +1000 +1500 0
CAR Panthers +135 -1667 -10000 -2000 -10000 0
Sat (12/24) @ 2:01pm ET HOU Texans +260 -5000 -3333 0 0 -5000
TEN Titans -345 +1400 +1000 +4500 +2200 +1700
Sat (12/24) @ 4:05pm ET WAS Commanders +275 +1700 +1150 +475 +240 +1700 +3500
SF 49ers -345 -10000 -5000 -714 -278 -10000 -10000
Sat (12/24) @ 4:25pm ET PHI Eagles +100 +310 +250 +400 +175 +470 +450
DAL Cowboys -120 -417 -345 -556 -200 -769 -625
Sat (12/24) @ 8:16pm ET LV Raiders +110 +600 +900 +5000 +1000 +700
PIT Steelers -135 -909 -2000 0 -3333 -1429
Sun (12/25) @ 1:02pm ET GB Packers +165 -233 -250 -233 +162 -244 -417
MIA Dolphins -200 +185 +190 +185 -185 +186 +330
Sun (12/25) @ 4:36pm ET DEN Broncos -110 +2000 +1450 +1400 +2000 +9000
LA Rams -110 -10000 -10000 -5000 0 0
Sun (12/25) @ 8:23pm ET TB Buccaneers -189 -5000 -5000 -5000 -345 -10000 -1000
ARI Cardinals +155 +1400 +1400 +1400 +290 +1500 +550
Mon (12/26) @ 8:15pm ET LA Chargers -164 -1667 -10000 -1667 -3333 -2000
IND Colts +135 +900 +3300 +900 +1060 +1100
Thu (12/22) @ 8:16pm ET JAX Jaguars +1.0 -115 -15.5 -476 -15.5 -10000 -16.0 -110 -15.5 -455 -16.0 +190
NY Jets -1.0 -105 +15.5 +350 +15.5 +1900 +16.0 -120 +15.5 +305 +16.0 -238
Sat (12/24) @ 1:00pm ET SEA Seahawks +10.0 -110 +13.5 +1300 +13.5 +675 +13.5 +625 +10.0 -109 +20.5 -106 +14.0 -250
KC Chiefs -10.0 -110 -13.5 -5000 -13.5 -1429 -13.5 -1000 -10.0 -112 -20.5 -122 -14.0 +210
Sat (12/24) @ 1:00pm ET NY Giants +3.5 -110 +3.5 -110 +2.5 +100 +3.5 -125 +5.0 -114 +3.5 -114 +3.5 +110
MIN Vikings -3.5 -110 -3.5 -120 -2.5 -130 -3.5 -105 -5.0 -108 -3.5 -114 -3.5 -125
Sat (12/24) @ 1:00pm ET CIN Bengals -4.0 -110 -8.5 -115 -7.5 +110 +2.5 +100 -3.0 -114 -7.5 +100 -4.0 0
NE Patriots +4.0 -110 +8.5 -115 +7.5 -145 -2.5 -130 +3.0 -108 +7.5 -130 +4.0 0
Sat (12/24) @ 1:02pm ET ATL Falcons +7.0 -115 +10.5 +115 +8.5 -909 +7.5 +525 +10.5 +148 +10.5 +105
BAL Ravens -7.0 -105 -10.5 -145 -8.5 +525 -7.5 -833 -10.5 -196 -10.5 -120
Sat (12/24) @ 1:02pm ET NO Saints +3.5 -115 -7.5 +115 -6.5 -278 -7.0 +700 -7.5 -102 -7.5 +140
CLE Browns -3.5 -105 +7.5 -145 +6.5 +200 +7.0 -1250 +7.5 -128 +7.5 -169
Sat (12/24) @ 1:02pm ET BUF Bills -9.5 -105 -14.5 -303 -15.5 -130 -15.5 +150 -15.5 +138 -15.0 +110
CHI Bears +9.5 -115 +14.5 +240 +15.5 +100 +15.5 -179 +15.5 -182 +15.0 -130
Sat (12/24) @ 1:02pm ET DET Lions -3.0 -110 +16.5 +290 +15.5 +125 +16.5 +700 +16.5 +290 +16.5 +145
CAR Panthers +3.0 -110 -16.5 -385 -15.5 -164 -16.5 -1250 -16.5 -417 -16.5 -175
Sat (12/24) @ 2:01pm ET HOU Texans +7.0 -110 +1.5 -135 -4.5 -345 +1.5 -120 +4.5 -147 -4.5 -323
TEN Titans -7.0 -110 -1.5 +105 +4.5 +240 -1.5 -110 -4.5 +114 +4.5 +250
Sat (12/24) @ 4:05pm ET WAS Commanders +7.5 -110 +16.5 +800 +16.5 +850 +16.5 +420 +6.5 -109 +17.5 -3333 +17.0 -238
SF 49ers -7.5 -110 -16.5 -1429 -16.5 -2500 -16.5 -588 -6.5 -112 -17.5 +980 -17.0 +200
Sat (12/24) @ 4:25pm ET PHI Eagles +1.5 -110 -2.5 -145 -3.5 +125 +1.5 -110 +4.0 -109 -1.5 -114 +1.5 -110
DAL Cowboys -1.5 -110 +2.5 +115 +3.5 -161 -1.5 -120 -4.0 -112 +1.5 -114 -1.5 -105
Sat (12/24) @ 8:16pm ET LV Raiders +2.5 -110 -3.5 -161 -3.5 -185 -3.5 -169 -3.5 -179 -3.5 -189
PIT Steelers -2.5 -110 +3.5 +130 +3.5 +140 +3.5 +140 +3.5 +136 +3.5 +160
Sun (12/25) @ 1:02pm ET GB Packers +4.5 -110 -1.5 -105 -2.5 -110 -1.5 -120 +3.5 -118 -2.5 -118 -5.5 0
MIA Dolphins -4.5 -110 +1.5 -125 +2.5 -120 +1.5 -110 -3.5 -104 +2.5 -110 +5.5 0
Sun (12/25) @ 4:36pm ET DEN Broncos -1.0 -105 +29.5 -110 +35.5 +375 +37.0 -556 +35.5 +168 +36.5 +165
LA Rams +1.0 -115 -29.5 -120 -35.5 -588 -37.0 +400 -35.5 -227 -36.5 -200
Sun (12/25) @ 8:23pm ET TB Buccaneers -3.5 -110 -2.5 -135 +2.5 +125 +5.5 -110 -7.5 -110 +6.5 -122 +3.0 0
ARI Cardinals +3.5 -110 +2.5 +105 -2.5 -161 -5.5 -120 +7.5 -110 -6.5 -106 -3.0 0
Mon (12/26) @ 8:15pm ET LA Chargers -3.0 -110 -16.5 -1250 -16.5 -2000 -17.0 -400 -16.5 -1000 -17.0 -149
IND Colts +3.0 -110 +16.5 +700 +16.5 +825 +17.0 +300 +16.5 +550 +17.0 +130
Thu (12/22) @ 8:16pm ET JAX Jaguars o39.5 -110 o22.5 +130 o29.5 +105 o22.5 +118 o23.5 +175
NY Jets u39.5 -110 u22.5 -161 u29.5 -135 u22.5 -154 u23.5 -208
Sat (12/24) @ 1:00pm ET SEA Seahawks u49.5 -110 u27.5 -145 u35.5 -1000 u48.5 -110 u49.5 -110 u27.5 -135 u28.5 -169
KC Chiefs o49.5 -110 o27.5 +115 o35.5 +575 o48.5 -110 o49.5 -110 o27.5 +104 o28.5 +140
Sat (12/24) @ 1:00pm ET NY Giants u47.5 -110 u37.5 -120 u39.5 -105 u48 -110 u48.0 -108 u38.5 -114 u37 +110
MIN Vikings o47.5 -110 o37.5 -110 o39.5 -120 o48 -110 o48.0 -114 o38.5 -114 o37 -125
Sat (12/24) @ 1:00pm ET CIN Bengals o39.5 -110 o40.5 -105 o40.5 -154 o41.5 -110 o41.5 -110 o40.5 -152 o43.5 0
NE Patriots u39.5 -110 u40.5 -125 u40.5 +120 u41.5 -110 u41.5 -110 u40.5 +116 u43.5 0
Sat (12/24) @ 1:02pm ET ATL Falcons o40.5 -110 o25.5 -135 o26.5 +625 o26.5 +134 o26 -120
BAL Ravens u40.5 -110 u25.5 +105 u26.5 -1250 u26.5 -175 u26 +105
Sat (12/24) @ 1:02pm ET NO Saints u35.5 -110 u32.5 +100 u30.5 -115 u33.5 -154 u32.5 +100
CLE Browns o35.5 -110 o32.5 -130 o30.5 -115 o33.5 +118 o32.5 -115
Sat (12/24) @ 1:02pm ET BUF Bills o42.5 -110 o40.5 -141 o41.5 -185 o40.5 -114 o41.5 +175
CHI Bears u42.5 -110 u40.5 +110 u41.5 +140 u40.5 -114 u41.5 -208
Sat (12/24) @ 1:02pm ET DET Lions u43.5 -105 u54.5 -145 u58.5 -400 u59.5 -102 u57 +115
CAR Panthers o43.5 -115 o54.5 +115 o58.5 +280 o59.5 -128 o57 -135
Sat (12/24) @ 2:01pm ET HOU Texans o40.5 -110 o32.5 -125 o33.5 +210 o30.5 -114 o33.5 +200
TEN Titans u40.5 -110 u32.5 -105 u33.5 -278 u30.5 -115 u33.5 -250
Sat (12/24) @ 4:05pm ET WAS Commanders u39.5 -110 u50.5 -141 u50.5 -105 u37.5 -109 u50.5 -130 u53.5 -141
SF 49ers o39.5 -110 o50.5 +110 o50.5 -125 o37.5 -112 o50.5 +100 o53.5 +120
Sat (12/24) @ 4:25pm ET PHI Eagles u50.5 -110 u74.5 -105 u70.5 -115 u48.0 -114 u74.5 -122 u74.5 +105
DAL Cowboys o50.5 -110 o74.5 -125 o70.5 -115 o48.0 -108 o74.5 -106 o74.5 -120
Sat (12/24) @ 8:16pm ET LV Raiders o40.5 -110 o19.5 -105 o20.5 +100 o19.5 -106 o19 +100
PIT Steelers u40.5 -110 u19.5 -125 u20.5 -130 u19.5 -122 u19 -115
Sun (12/25) @ 1:02pm ET GB Packers o46.5 -110 o49.5 -130 o53.5 +100 o49.5 -110 o49.5 -109 o53.5 +102 o50 0
MIA Dolphins u46.5 -110 u49.5 +100 u53.5 -125 u49.5 -110 u49.5 -112 u53.5 -132 u50 0
Sun (12/25) @ 4:36pm ET DEN Broncos o35.5 -110 o58.5 +125 o60.5 -115 o53.5 -145 o65.5 +140
LA Rams u35.5 -110 u58.5 -154 u60.5 -115 u53.5 +110 u65.5 -169
Sun (12/25) @ 8:23pm ET TB Buccaneers u40.5 -110 u31.5 -115 u35.5 -154 u42.0 -109 u31.5 -108 u35 0
ARI Cardinals o40.5 -110 o31.5 -115 o35.5 +120 o42.0 -112 o31.5 -120 o35 0
Mon (12/26) @ 8:15pm ET LA Chargers u47.5 -110 u26.5 -154 u24.5 -130 u29.5 -118 u24.5 -169
IND Colts o47.5 -110 o26.5 +125 o24.5 +100 o29.5 -110 o24.5 +140

NFL Week 16 Odds

Here’s a game-by-game peek at NFL Week 16 betting lines from DraftKings:

Jaguars at Jets (-1, 39.5) — TNF

The Jets have been favored at home only once this season. They covered as an 8.5-point favorite in a 31-10 win over Chicago in Week 12. Jacksonville is 2-5 SU on the road this year.

Saturday, Dec. 24

Seahawks at Chiefs (-10, 49.5)

Kansas City slept-walked through much of yesterday’s 30-24 OT win at Houston, but the day ended with the Chiefs securing their seventh straight AFC West division title.

KC has been costing its backers in home games, going 1-5 ATS at Arrowhead Stadium. The Chiefs have also failed to cover the number in their last five games.

Bills (-9, 41) at Bears

For all their success this year, the Bills have still managed to cover once in their last eight games. The Bears played the Eagles tough yesterday and covered in a 25-20 loss at home.

Eagles at Cowboys (-1, 51.5)

Week 16’s marquee matchup sees Philadelphia traveling to Dallas for this NFC East grudge match. The Cowboys are coming off a 40-34 OT loss at Jacksonville.

The Cowboys and QB Dak Prescott are slight favorites against the Eagles, per NFL Week 16 odds. (AP Photo/Matt Ludtke)

The Eagles are only 2-5 ATS in road tilts this season. The Cowboys are 5-3 ATS at home.

Bengals (-3.5, 40) at Patriots

The Bengals (10-4) are jockeying with the Ravens (9-5) for the AFC North title. The Patriots (7-7) remain in playoff contention, but their last three games are against the Bengals, Dolphins, and Bills — arguably the toughest stretch on their schedule.

Lions (-3, 44.5) at Panthers

The Lions (7-7) have clawed their way back from a 1-6 start to the season. They likely need to go 3-0 down the stretch to make the playoffs. Carolina (5-9) somehow remains in playoff contention in the putrid NFC South.

Falcons at Ravens (-7, 40)

Baltimore needs to get QB Lamar Jackson (knee) back for this contest. The Ravens looked anemic in Saturday’s 13-3 loss at Cleveland. Baltimore faced a similar scenario last year when it lost Jackson after starting 8-3. The Ravens lost their last six games and missed the playoffs.

Giants at Vikings (-3.5, 47.5)

It took the greatest comeback in NFL history, but the Vikings (11-3) clinched the NFC North after their 39-36 OT win over the Colts. Minnesota failed to cover as a 4-point favorite.

Check out: NFL Week 15 Betting Tips

Sunday, Dec. 25

Packers at Dolphins (-4, 46.5)

Miami has now dropped three straight games. The Dolphins (8-6) are suddenly three games behind Buffalo in the AFC East after dropping a 32-29 decision to the Bills on Saturday.

Broncos (-1.5, 35.5) at Rams

The who cares game of the week. The Broncos are an astounding 11-3 to the Under this year.

Bucs (-4, 40.5) at Cardinals

Tampa Bay (6-8) is still somehow clinging to a one-game lead in the NFC South. After yesterday’s 34-23 loss to the Bengals, the Bucs have still yet to cover ATS at home this season at 0-6-1.

Chargers (-3.5, 47.5) at Colts — MNF

The Chargers pulled out a 17-14 win against Tennessee and pushed as a three-point favorite on Sunday. LA has been a solid bet on the road this year, going 5-2 ATS in away games.

The Rest of NFL Week 16 Games

Saints at Browns (-3, 34.5)

Texans at Titans (-7, 39)

Commanders at 49ers (-7, 40.5)

Raiders at Steelers (-2, 40.5)

Also read: Super Bowl 57 odds | 2022 NFL MVP odds

About the Author
Kris Johnson

Kris Johnson

Writer & Contributor
Kris Johnson is a Senior Writer at Gaming Today with more than 15 years of experience as a sports journalist. Kris' work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and more. Kris also authored a sports betting novel entitled The Endgame.

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