The second week of the 2022 NFL season is upon us, and it’s time to examine updated point spreads, moneylines, and totals. Here are NFL Week 2 odds from around the sports betting marketplace.
Here’s a game-by-game look at Week 2, which began with an AFC West showdown between the Los Angeles Chargers and Kansas City Chiefs on Thursday night. The Chiefs won 27-24, but failed to cover as a -3.5 home favorite. The game went under a total of 54.
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NFL Week 2 Odds
NFL Week 2 Point Spreads and Totals
Lines are via FanDuel as of Friday, Sept. 16. Always shop around the sports betting marketplace for the best odds for your wagers.

Commanders at Lions (-1.5, 48.5)
This line flipped in favor of Detroit by three full points at FanDuel since Monday. The Lions have received 73% of the bets and 76% of the overall handle.
I was at Two Kings Sportsbook in North Carolina working on a story last week. One bettor identified this game as his best bet of the week on a look-ahead line that was pick ‘em at the time. He’d bet the Lions “all day” here.
Until Detroit actually wins a game, it’s hard to get too excited about the Lions.
Bengals (-7.5, 41.5) at Cowboys
More serious movement here after the line previously flipped from Cowboys -2.5 to Bengals -6.5 on the news that Dallas QB Dak Prescott needs surgery on his thumb and will miss several weeks. Bettors have pushed the Bengals to -7.5 and driven the total down to 41.5.
A total of 86% of the bets and 84% of the handle were on Cincinnati as of Friday morning.
Dolphins at Ravens (-3.5, 44.5)
Congratulations if you took Baltimore in your Survivor pool in Week 1 as teams like Indianapolis, Tennessee, and San Francisco found a way to disappoint.
But looking ahead to this clash, it’s hard to forget what the Dolphins did to the Ravens last season. Miami’s defense smothered Lamar Jackson and made him look mortal in a 22-10 victory.
FanDuel bettors still believe in Baltimore as 80% of the betting handle is on the Ravens.
Jets at Browns (-6.5, 39.5)
The total for this game dropped a full point since Monday at FanDuel, where 85% of the handle and 72% of bets were on the under.
Southerners have a time-honored expression: “Bless your heart.” It’s often used disingenuously. Translation: You’re a hot mess. We truly feel for long-suffering fans of the Jets, who find new ways to disappoint every year.
Meanwhile, Cleveland’s defense is no joke and on offense it continues to run the ball with the league’s best. The Browns look like a solid Survivor pick in Week 2.
Colts (-4.5, 45.5) at Jaguars
This line has moved down a full point from Monday to Indy -3.5. FanDuel bettors have pounded the over with 84% of the handle on it.
There’s always one you didn’t see coming, right? We wrote about the Wong Teaser last week and selected Indianapolis -2 over Houston along with Minnesota, which handled Green Bay with ease.
There’s always a tendency to overreact in Week 2 of an NFL season, too, but Jacksonville +3.5 looks like a solid play anyway.
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Buccaneers (-2.5, 44.5) at Saints
Flip a coin on the side here? The betting handle for this NFC South matchup was split exactly down the middle at FanDuel.
The Saints owned the Bucs last year as they swept the season series, and dealt Tampa Bay two of its four losses during the regular season.
We used the Saints +8.5 and Steelers +7.5 in our Wong Teaser for NFL Week 2.
Patriots (-2.5, 40.5) at Steelers
Why is New England favored here? This line moved another 1.5 points in New England’s direction since Monday. FanDuel bettors don’t agree, either, as 78% of the bets are on Pittsburgh.
Steelers defensive stalwart T.J. Watt will miss this game with a torn pectoral muscle.
Panthers at Giants (-1.5, 43.5)
The Giants were -2.5 at FanDuel on Monday, and the total was 42.5. The percentage of bets on both sides was fairly even at FanDuel as was the total as of Friday.
Also read: Week 1 betting recap
Falcons at Rams (-9.5, 46.5)
The Rams have a potential get-well game after stumbling against the Bills in the NFL season opener, but 60% of the bets at FanDuel are backing the Falcons with the points.
Matthew Stafford will look to rebound from a poor Week 1 performance that saw him throw three picks and just one TD. He failed to throw multiple TDs in just four games last season.
Maybe his elbow isn’t fully recovered, or perhaps he just needs to spend more time with this iteration of Sean McVay’s offense.
LA was a double-digit favorite three times last season, and the Rams were 1-2 ATS in those games.
Seahawks at 49ers (-8.5, 41.5)
Tricky spot here, no? It’s difficult to take too much away from San Francisco’s season opener due to monsoon conditions in Chicago. Not keen on laying 8.5 points until Trey Lance proves himself at QB. FanDuel players are hammering the under at 91% of the handle on the total.
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Cardinals at Raiders (-5.5, 51.5)
This line jumped two points to Las Vegas -5.5 since the start of the week. The Raiders are the highly preferred side on the moneyline at FanDuel with 81% of the handle backing Las Vegas (-240 as of Friday).
Texans at Broncos (-9.5, 45.5)
Another game with fairly even money coming in on the side and total at FanDuel.
Houston was perhaps the biggest surprise in Week 1, taking Indianapolis to overtime before emerging with a hard-fought tie. But are the Texans worth taking as a big dog again in Denver? We’re not quite there yet.
Bears at Packers (-9.5, 41.5)
Yes, Aaron Rodgers has owned the Bears. But 61% of the bets on the spread have been on Chicago at FanDuel.
Chicago gave its fans a pleasant surprise in Week 1, and Green Bay looked like a hot mess against Minnesota. So, expect A-Rod to find a way to lead Green Bay to a double-digit cover on Sunday Night Football. Seriously, though, this game has stay away written all over it.
Packers: We're down by 1, 37 seconds on the clock and no timeouts
Aaron Rodgers: pic.twitter.com/MeEVdJaG7l
— FanDuel Sportsbook (@FDSportsbook) September 27, 2021
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Titans at Bills (-9.5, 48.5)
Do yourself a solid and read the Sharp Report by Rob Miech on Gaming Today each week. As Miech noted in this week’s installment, sharp bettors jumped on the Titans early at +10.5 at the South Point in Las Vegas.
Did you know the underdog has won the last four games in this series? The two teams met last October with the Bills laying -6 on the road. The Titans won that game outright, 34-31.
Vikings at Eagles (-2.5, 50.5)
The second of two MNF matchups this week features a pair of teams we’re bullish on in 2022. Philadelphia could be a sneaky good choice to win the NFC, and hopefully the Eagles were among your futures bets at the time this piece was published. They were down to +600 at FanDuel as of today.
Minnesota was +300 to win the NFC North at FanDuel in early August. The Vikings are now +130.
Also check: Super Bowl 57 odds
Oddsmakers at sportsbooks such as DraftKings and BetMGM set the odds for NFL games. The odds are adjusted based on how patrons are betting, injuries, trades, and other key developments.
That depends on your bet. Always shop around the industry to compare the odds being offered at different sportsbooks before making your bet.
The favorite team is listed as minus. For example, the Bills are -9.5 against the Titans in Week 2. That means Buffalo needs to win the game by 10 points to cover the spread.
The Buffalo Bills are the betting favorite to win Super Bowl 57. FanDuel was dealing the Bills at +500 as of Monday, Sept. 12.