NFL Week 2 Odds: Updated Point Spreads, Moneylines, and Totals

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The second week of the 2022 NFL season is upon us, and it’s time to examine updated point spreads, moneylines, and totals. Here are NFL Week 2 odds from around the sports betting marketplace.

Here’s a game-by-game look at Week 2, which began with an AFC West showdown between the Los Angeles Chargers and Kansas City Chiefs on Thursday night. The Chiefs won 27-24, but failed to cover as a -3.5 home favorite. The game went under a total of 54.

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NFL Week 2 Odds

Bet TypeSpreads
Open
Thu (9/15) @ 8:15pm ET LA Chargers +145 +1300 +1600 +2000 +10000 +4000
KC Chiefs -175 -5000 -10000 -5000 0 0
Sun (9/18) @ 1:02pm ET NE Patriots -120 -2500 -5000 -2500 -5000 -2500
PIT Steelers +100 +1100 +1250 +1100 +1300 +1200
Sun (9/18) @ 1:02pm ET MIA Dolphins +150 -10000 -3333 -2500 -213 -179
BAL Ravens -185 +1700 +1150 +1100 +164 +150
Sun (9/18) @ 1:02pm ET WAS Commanders +110 +540 +1050 +575 +10000 +6000
DET Lions -135 -1000 -2500 -909 0 0
Sun (9/18) @ 1:02pm ET IND Colts -200 +1200 +3300 +900 +2500 +15000
JAX Jaguars +170 -3333 -10000 -1667 0 0
Sun (9/18) @ 1:02pm ET TB Buccaneers -135 -10000 -10000 -3333 0 -5000
NO Saints +110 +2000 +3300 +1200 +10000 +1800
Sun (9/18) @ 1:03pm ET NY Jets +220 -169 -3333 +1100 0 -370
CLE Browns -278 +130 +1100 -2500 0 +300
Sun (9/18) @ 1:03pm ET CAR Panthers +110 +1800 +900 +1100 +3500 +1200
NY Giants -130 -10000 -2000 -2500 0 -2500
Sun (9/18) @ 4:05pm ET SEA Seahawks +325 +1500 +3300 +1400 +310 +10000 +1500
SF 49ers -400 -5000 -10000 -5000 -370 0 -5000
Sun (9/18) @ 4:05pm ET ATL Falcons +550 +575 +1400 +575 +375 +310 +3000
LA Rams -833 -909 -5000 -909 -455 -435 -10000
Sun (9/18) @ 4:25pm ET ARI Cardinals +155 +470 +450 +420 +195 +430 0
LV Raiders -185 -714 -667 -588 -238 -667 0
Sun (9/18) @ 4:25pm ET HOU Texans +340 +1000 +1050 +575 +390 +10000 +1800
DEN Broncos -455 -2000 -2000 -909 -476 0 -5000
Sun (9/18) @ 4:26pm ET CIN Bengals -250 +460 +375 +625 -333 0 0
DAL Cowboys +200 -667 -500 -1000 +275 0 0
Sun (9/18) @ 8:22pm ET CHI Bears +325 +2200 +3300 +1400 +375 +10000 0
GB Packers -455 -10000 -10000 -5000 -476 0 0
Mon (9/19) @ 7:15pm ET TEN Titans +325 +1800 +3300 +1100 +10000 +17500
BUF Bills -455 -10000 -10000 -2500 0 0
Mon (9/19) @ 8:31pm ET MIN Vikings +120 +1800 +1500 +1100 +10000 +10000
PHI Eagles -145 -10000 -10000 -2500 0 0
Thu (9/15) @ 8:15pm ET LA Chargers +3.0 -105 +7.5 -149 +2.5 +1150 +7.5 -169 +3.5 0 +9.5 +110
KC Chiefs -3.0 -115 -7.5 +120 -2.5 -3333 -7.5 +140 -3.5 +7000 -9.5 -130
Sun (9/18) @ 1:02pm ET NE Patriots -1.5 -110 -3.0 -105 -3.5 +180 -2.5 -233 -5.5 -278 -3.0 -108
PIT Steelers +1.5 -110 +3.0 -125 +3.5 -227 +2.5 +185 +5.5 +205 +3.0 -108
Sun (9/18) @ 1:02pm ET MIA Dolphins +3.5 -115 +2.5 +100 +2.5 +135 -4.0 +525 -3.5 +108 +2.5 +120
BAL Ravens -3.5 -105 -2.5 -130 -2.5 -164 +4.0 -833 +3.5 -141 -2.5 -141
Sun (9/18) @ 1:02pm ET WAS Commanders +1.5 -105 +9.0 -667 +8.5 +500 +9.0 +525 +9.5 -2000 +11.5 -108
DET Lions -1.5 -115 -9.0 +450 -8.5 -714 -9.0 -833 -9.5 +790 -11.5 -108
Sun (9/18) @ 1:02pm ET IND Colts -4.5 -110 +24.0 +210 +24.5 -250 +24.0 +170 +24.5 -1250 +24.0 +310
JAX Jaguars +4.5 -110 -24.0 -263 -24.5 +190 -24.0 -208 -24.5 +600 -24.0 -400
Sun (9/18) @ 1:02pm ET TB Buccaneers -2.5 -110 -10.0 +550 -10.5 +2800 -10.0 +240 -9.5 -1250 -10.0 +190
NO Saints +2.5 -110 +10.0 -833 +10.5 -10000 +10.0 -303 +9.5 +630 +10.0 -238
Sun (9/18) @ 1:03pm ET NY Jets +6.0 -110 +5.5 +1800 -1.5 +775 -1.0 0 -0.5 0 +7.0 +105
CLE Browns -6.0 -110 -5.5 -10000 +1.5 -1429 +1.0 +3000 +0.5 +2200 -7.0 -120
Sun (9/18) @ 1:03pm ET CAR Panthers +2.5 -110 +3.0 +100 +3.5 -345 +3.0 -250 +3.5 0 +3.0 -115
NY Giants -2.5 -110 -3.0 -130 -3.5 +260 -3.0 +200 -3.5 +3500 -3.0 +100
Sun (9/18) @ 4:05pm ET SEA Seahawks +9.5 -110 +19.5 +295 +19.5 +575 +19.5 +575 +8.5 -114 +19.5 +2500 +16.5 -125
SF 49ers -9.5 -110 -19.5 -385 -19.5 -909 -19.5 -909 -8.5 -108 -19.5 0 -16.5 +110
Sun (9/18) @ 4:05pm ET ATL Falcons +11.5 -110 +6.0 -130 +6.5 -161 +4.0 -263 +10.5 -114 +5.5 +182 +6.0 +120
LA Rams -11.5 -110 -6.0 +100 -6.5 +135 -4.0 +210 -10.5 -108 -5.5 -244 -6.0 -141
Sun (9/18) @ 4:25pm ET ARI Cardinals +3.5 -110 +5.5 -125 +4.5 -105 +7.5 +100 +5.5 -108 +0.5 -118 +7.5 +110
LV Raiders -3.5 -110 -5.5 -105 -4.5 -115 -7.5 -130 -5.5 -114 -0.5 -110 -7.5 -130
Sun (9/18) @ 4:25pm ET HOU Texans +10.0 -110 +6.5 +200 +3.5 +135 +6.5 -110 +10.0 -110 +7.5 0 +7.0 -149
DEN Broncos -10.0 -110 -6.5 -250 -3.5 -161 -6.5 -120 -10.0 -110 -7.5 +2500 -7.0 +130
Sun (9/18) @ 4:26pm ET CIN Bengals -6.0 -110 +3.5 -115 +3.5 -115 +3.5 -115 -7.0 -114 +3.5 +182 +4.0 -110
DAL Cowboys +6.0 -110 -3.5 -115 -3.5 -105 -3.5 -115 +7.0 -108 -3.5 +7500 -4.0 -105
Sun (9/18) @ 8:22pm ET CHI Bears +9.5 -110 +16.5 +420 +16.5 +400 +17.0 +900 +10.5 -114 +17.5 0 +17.0 0
GB Packers -9.5 -110 -16.5 -588 -16.5 -556 -17.0 -1667 -10.5 -108 -17.5 +5000 -17.0 0
Mon (9/19) @ 7:15pm ET TEN Titans +9.5 -105 +37.0 +115 +37.5 -110 +36.5 +120 +34.5 -244 +36.5 +100
BUF Bills -9.5 -115 -37.0 -145 -37.5 -110 -36.5 -149 -34.5 +182 -36.5 -115
Mon (9/19) @ 8:31pm ET MIN Vikings +3.0 -115 +16.5 +140 +16.5 -185 +16.5 +575 +16.5 -120 +17.0 +115
PHI Eagles -3.0 -105 -16.5 -175 -16.5 +150 -16.5 -909 -16.5 -108 -17.0 -135
Thu (9/15) @ 8:15pm ET LA Chargers u54.5 -110 u48.5 -125 u49.5 -110 u51.5 0 u48 +110
KC Chiefs o54.5 -110 o48.5 -105 o49.5 -110 o51.5 +7000 o48 -125
Sun (9/18) @ 1:02pm ET NE Patriots o40.5 -110 o37.5 -125 o37.5 +105 o33.5 -476 o37 -125
PIT Steelers u40.5 -110 u37.5 -105 u37.5 -125 u33.5 +325 u37 +110
Sun (9/18) @ 1:02pm ET MIA Dolphins u45.5 -110 u76 -110 u76.5 -110 u79.5 +116 u76 +100
BAL Ravens o45.5 -110 o76 -120 o76.5 -110 o79.5 -152 o76 -115
Sun (9/18) @ 1:02pm ET WAS Commanders u46.5 -105 u63.5 +105 u63.5 -400 u63.5 -2000 u64 -135
DET Lions o46.5 -115 o63.5 -135 o63.5 +310 o63.5 +750 o64 +115
Sun (9/18) @ 1:02pm ET IND Colts o45.5 -115 o24.5 +145 o25.5 -115 o24.5 +560 o25.5 +250
JAX Jaguars u45.5 -105 u24.5 -179 u25.5 -105 u24.5 -1000 u25.5 -323
Sun (9/18) @ 1:02pm ET TB Buccaneers u45.5 -110 u19 -115 u31.5 -10000 u30.5 -909 u31.5 -108
NO Saints o45.5 -110 o19 -115 o31.5 +2000 o30.5 +530 o31.5 -108
Sun (9/18) @ 1:03pm ET NY Jets u42.5 -110 u43.5 -110 u63.5 -714 u61.5 0 u41.5 -120
CLE Browns o42.5 -110 o43.5 -120 o63.5 +500 o61.5 +1700 o41.5 +105
Sun (9/18) @ 1:03pm ET CAR Panthers o43.5 -110 o42 -110 o35.5 +155 o35.5 +1600 o39 -120
NY Giants u43.5 -110 u42 -120 u35.5 -189 u35.5 0 u39 +105
Sun (9/18) @ 4:05pm ET SEA Seahawks u42.5 -115 u34 -125 u35.5 -667 u39.5 -110 u39.5 -109 u34.5 0 u33.5 +145
SF 49ers o42.5 -105 o34 -105 o35.5 +450 o39.5 -110 o39.5 -112 o34.5 +1700 o33.5 -175
Sun (9/18) @ 4:05pm ET ATL Falcons o47.5 -110 o56.5 +100 o49.5 -110 o46.0 -112 o56.5 +130 o56.5 +125
LA Rams u47.5 -110 u56.5 -130 u49.5 -110 u46.0 -109 u56.5 -169 u56.5 -145
Sun (9/18) @ 4:25pm ET ARI Cardinals o51.5 -110 o43.5 -115 o44.5 +165 o52.0 -110 o49.5 +280 o39.5 +100
LV Raiders u51.5 -110 u43.5 -115 u44.5 -200 u52.0 -110 u49.5 -400 u39.5 -115
Sun (9/18) @ 4:25pm ET HOU Texans u43.5 -105 u25.5 -161 u31.5 -120 u45.5 -108 u25.5 0 u25.5 -125
DEN Broncos o43.5 -115 o25.5 +130 o31.5 +100 o45.5 -114 o25.5 +2200 o25.5 +110
Sun (9/18) @ 4:26pm ET CIN Bengals o44.5 -110 o35 -105 o35.5 +100 o42.0 -109 o37.5 +7500 o35 -105
DAL Cowboys u44.5 -110 u35 -125 u35.5 -120 u42.0 -112 u37.5 -526 u35 -110
Sun (9/18) @ 8:22pm ET CHI Bears o44.5 -110 o37.5 +370 o52.5 -120 o42.0 -108 o37.5 +4000 o37.5 0
GB Packers u44.5 -110 u37.5 -500 u52.5 +100 u42.0 -114 u37.5 0 u37.5 0
Mon (9/19) @ 7:15pm ET TEN Titans u49.5 -110 u51.5 -125 u52.5 -130 u48.5 -256 u51 -145
BUF Bills o49.5 -110 o51.5 -105 o52.5 +105 o48.5 +188 o51 +125
Mon (9/19) @ 8:31pm ET MIN Vikings o49.5 -110 o40.5 -115 o37.5 -105 o31.5 -114 o31.5 +105
PHI Eagles u49.5 -110 u40.5 -115 u37.5 -115 u31.5 -115 u31.5 -120

NFL Week 2 Point Spreads and Totals 

Lines are via FanDuel as of Friday, Sept. 16. Always shop around the sports betting marketplace for the best odds for your wagers.

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Detroit is now favored against Washington in Week 2. (AP Photo/Paul Sancya)

Commanders at Lions (-1.5, 48.5)

This line flipped in favor of Detroit by three full points at FanDuel since Monday. The Lions have received 73% of the bets and 76% of the overall handle.

I was at Two Kings Sportsbook in North Carolina working on a story last week. One bettor identified this game as his best bet of the week on a look-ahead line that was pick ‘em at the time. He’d bet the Lions “all day” here.

Until Detroit actually wins a game, it’s hard to get too excited about the Lions.

Bengals (-7.5, 41.5) at Cowboys

More serious movement here after the line previously flipped from Cowboys -2.5 to Bengals -6.5 on the news that Dallas QB Dak Prescott needs surgery on his thumb and will miss several weeks. Bettors have pushed the Bengals to -7.5 and driven the total down to 41.5.

A total of 86% of the bets and 84% of the handle were on Cincinnati as of Friday morning.

Dolphins at Ravens (-3.5, 44.5)

Congratulations if you took Baltimore in your Survivor pool in Week 1 as teams like Indianapolis, Tennessee, and San Francisco found a way to disappoint.    

But looking ahead to this clash, it’s hard to forget what the Dolphins did to the Ravens last season. Miami’s defense smothered Lamar Jackson and made him look mortal in a 22-10 victory.

FanDuel bettors still believe in Baltimore as 80% of the betting handle is on the Ravens.

Jets at Browns (-6.5, 39.5)

The total for this game dropped a full point since Monday at FanDuel, where 85% of the handle and 72% of bets were on the under.

Southerners have a time-honored expression: “Bless your heart.” It’s often used disingenuously. Translation: You’re a hot mess. We truly feel for long-suffering fans of the Jets, who find new ways to disappoint every year.

Meanwhile, Cleveland’s defense is no joke and on offense it continues to run the ball with the league’s best. The Browns look like a solid Survivor pick in Week 2.  

Colts (-4.5, 45.5) at Jaguars

This line has moved down a full point from Monday to Indy -3.5. FanDuel bettors have pounded the over with 84% of the handle on it.

There’s always one you didn’t see coming, right? We wrote about the Wong Teaser last week and selected Indianapolis -2 over Houston along with Minnesota, which handled Green Bay with ease. 

There’s always a tendency to overreact in Week 2 of an NFL season, too, but Jacksonville +3.5 looks like a solid play anyway.

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Buccaneers (-2.5, 44.5) at Saints

Flip a coin on the side here? The betting handle for this NFC South matchup was split exactly down the middle at FanDuel.

The Saints owned the Bucs last year as they swept the season series, and dealt Tampa Bay two of its four losses during the regular season.

We used the Saints +8.5 and Steelers +7.5 in our Wong Teaser for NFL Week 2.  

Patriots (-2.5, 40.5) at Steelers  

Why is New England favored here? This line moved another 1.5 points in New England’s direction since Monday. FanDuel bettors don’t agree, either, as 78% of the bets are on Pittsburgh.

Steelers defensive stalwart T.J. Watt will miss this game with a torn pectoral muscle. 

Panthers at Giants (-1.5, 43.5)

The Giants were -2.5 at FanDuel on Monday, and the total was 42.5. The percentage of bets on both sides was fairly even at FanDuel as was the total as of Friday.

Also read: Week 1 betting recap

Falcons at Rams (-9.5, 46.5)

The Rams have a potential get-well game after stumbling against the Bills in the NFL season opener, but 60% of the bets at FanDuel are backing the Falcons with the points.

Matthew Stafford will look to rebound from a poor Week 1 performance that saw him throw three picks and just one TD. He failed to throw multiple TDs in just four games last season.

Maybe his elbow isn’t fully recovered, or perhaps he just needs to spend more time with this iteration of Sean McVay’s offense. 

LA was a double-digit favorite three times last season, and the Rams were 1-2 ATS in those games.    

Seahawks at 49ers (-8.5, 41.5) 

Tricky spot here, no? It’s difficult to take too much away from San Francisco’s season opener due to monsoon conditions in Chicago. Not keen on laying 8.5 points until Trey Lance proves himself at QB. FanDuel players are hammering the under at 91% of the handle on the total.

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Cardinals at Raiders (-5.5, 51.5)

This line jumped two points to Las Vegas -5.5 since the start of the week. The Raiders are the highly preferred side on the moneyline at FanDuel with 81% of the handle backing Las Vegas (-240 as of Friday).

Texans at Broncos (-9.5, 45.5)

Another game with fairly even money coming in on the side and total at FanDuel.

Houston was perhaps the biggest surprise in Week 1, taking Indianapolis to overtime before emerging with a hard-fought tie. But are the Texans worth taking as a big dog again in Denver? We’re not quite there yet.      

Bears at Packers (-9.5, 41.5) 

Yes, Aaron Rodgers has owned the Bears. But 61% of the bets on the spread have been on Chicago at FanDuel.

Chicago gave its fans a pleasant surprise in Week 1, and Green Bay looked like a hot mess against Minnesota. So, expect A-Rod to find a way to lead Green Bay to a double-digit cover on Sunday Night Football. Seriously, though, this game has stay away written all over it. 

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Titans at Bills (-9.5, 48.5)

Do yourself a solid and read the Sharp Report by Rob Miech on Gaming Today each week. As Miech noted in this week’s installment, sharp bettors jumped on the Titans early at +10.5 at the South Point in Las Vegas.

Did you know the underdog has won the last four games in this series? The two teams met last October with the Bills laying -6 on the road. The Titans won that game outright, 34-31.     

Vikings at Eagles (-2.5, 50.5)

The second of two MNF matchups this week features a pair of teams we’re bullish on in 2022. Philadelphia could be a sneaky good choice to win the NFC, and hopefully the Eagles were among your futures bets at the time this piece was published. They were down to +600 at FanDuel as of today.

Minnesota was +300 to win the NFC North at FanDuel in early August. The Vikings are now +130.

Also check: Super Bowl 57 odds

Who sets the NFL odds for Week 2?

Oddsmakers at sportsbooks such as DraftKings and BetMGM set the odds for NFL games. The odds are adjusted based on how patrons are betting, injuries, trades, and other key developments.

Who has the best NFL odds?

That depends on your bet. Always shop around the industry to compare the odds being offered at different sportsbooks before making your bet.

Is the favored team plus or minus?

The favorite team is listed as minus. For example, the Bills are -9.5 against the Titans in Week 2. That means Buffalo needs to win the game by 10 points to cover the spread.

Who is favored to win Super Bowl 57?

The Buffalo Bills are the betting favorite to win Super Bowl 57. FanDuel was dealing the Bills at +500 as of Monday, Sept. 12.

About the Author
Kris Johnson

Kris Johnson

Writer & Contributor
Kris Johnson is a Senior Writer at Gaming Today with more than 15 years of experience as a sports journalist. Kris' work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and more. Kris also authored a sports betting novel entitled The Endgame.

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