NFL Week 2 Odds: Updated Point Spreads, Moneylines, and Totals

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The second week of the 2022 NFL season is upon us, and it’s time to examine updated point spreads, moneylines, and totals. Here are NFL Week 2 odds from around the sports betting marketplace.

Here’s a game-by-game look at Week 2, which began with an AFC West showdown between the Los Angeles Chargers and Kansas City Chiefs on Thursday night. The Chiefs won 27-24, but failed to cover as a -3.5 home favorite. The game went under a total of 54.

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NFL Week 2 Odds

Bet TypeSpreads
Open
Thu (9/14) @ 8:16pm ET MIN Vikings +280 +1600 +1550 +1800 +216 +1700 +1800
PHI Eagles -345 -5000 -10000 -5000 -250 -10000 -5000
Sun (9/17) @ 1:01pm ET BAL Ravens +135 -2000 -1000 -1667 +147 -1667 -3333
CIN Bengals -161 +1000 +600 +800 -167 +800 +1200
Sun (9/17) @ 1:01pm ET LA Chargers -149 +470 +600 +1000 -143 +750 +600
TEN Titans +125 -769 -1111 -2500 +126 -1667 -1111
Sun (9/17) @ 1:02pm ET CHI Bears +115 +390 +400 +350 +630 +8000
TB Buccaneers -141 -588 -667 -500 -1250 0
Sun (9/17) @ 1:02pm ET LV Raiders +350 +2500 +3300 +850 +4000 +6600
BUF Bills -455 -10000 -10000 -1667 0 0
Sun (9/17) @ 1:03pm ET SEA Seahawks +185 -417 -400 -303 -161 0
DET Lions -227 +300 +300 +230 +126 0
Sun (9/17) @ 1:03pm ET IND Colts +100 -5000 -10000 -5000 -10000 0
HOU Texans -120 +1600 +3300 +1400 +1700 +10000
Sun (9/17) @ 1:03pm ET KC Chiefs -154 -3333 -10000 -5000 -5000 0
JAX Jaguars +130 +1400 +3300 +1400 +1100 +7000
Sun (9/17) @ 1:05pm ET GB Packers -115 +850 +800 +3500 +1060 -149
ATL Falcons -105 -1667 -1667 0 -3333 +115
Sun (9/17) @ 4:06pm ET NY Giants -208 0 -10000 0 -213 0 -5000
ARI Cardinals +170 +4000 +1400 +3000 +185 +3500 +600
Sun (9/17) @ 4:06pm ET SF 49ers -278 -2000 -2500 0 -333 -2500 0
LA Rams +225 +1000 +950 +6000 +275 +900 +4000
Sun (9/17) @ 4:26pm ET NY Jets +140 +2200 +3300 +3500 +345 +1800 +1300
DAL Cowboys -164 -10000 -10000 0 -417 0 -10000
Sun (9/17) @ 4:27pm ET WAS Commanders +165 -208 -345 -1667 +165 -3333 0
DEN Broncos -200 +160 +250 +850 -189 +1000 +4500
Sun (9/17) @ 8:25pm ET MIA Dolphins -135 -909 -833 -588 -130 -909 0
NE Patriots +110 +550 +500 +400 +114 +540 0
Mon (9/18) @ 7:19pm ET NO Saints -145 -10000 -588 0 -164 0 0
CAR Panthers +120 +2500 +400 +1200 +144 +2500 +15000
Mon (9/18) @ 8:20pm ET CLE Browns -115 +400 +400 +420 -135 +215 +475
PIT Steelers -105 -625 -667 -667 +120 -294 -833
Thu (9/14) @ 8:16pm ET MIN Vikings +7.5 -110 +11.5 -115 +5.5 +3300 +6.5 -238 +6.0 -112 +9.5 -128 +9.5 -120
PHI Eagles -7.5 -110 -11.5 -115 -5.5 -10000 -6.5 +185 -6.0 -109 -9.5 -102 -9.5 -105
Sun (9/17) @ 1:01pm ET BAL Ravens +3.0 -115 -7.5 +110 -2.5 -833 -3.0 -833 +3.5 -115 -2.5 -1667 -3.0 +120
CIN Bengals -3.0 -105 +7.5 -141 +2.5 +475 +3.0 +500 -3.5 -106 +2.5 +750 +3.0 -149
Sun (9/17) @ 1:01pm ET LA Chargers -3.0 -110 -3.5 -130 +2.5 +950 -4.5 +125 -2.5 -115 -4.5 -102 -4.5 +110
TEN Titans +3.0 -110 +3.5 +100 -2.5 -3333 +4.5 -161 +2.5 -106 +4.5 -128 +4.5 -141
Sun (9/17) @ 1:02pm ET CHI Bears +2.5 -110 +9.5 +520 +9.5 +525 +9.5 +110 +9.5 +195 +3.0 +160
TB Buccaneers -2.5 -110 -9.5 -833 -9.5 -1000 -9.5 -141 -9.5 -263 -3.0 -200
Sun (9/17) @ 1:02pm ET LV Raiders +9.5 -110 +27.5 +1400 +29.5 -909 +28.0 -455 +21.5 +100 +28.0 -400
BUF Bills -9.5 -110 -27.5 -3333 -29.5 +500 -28.0 +320 -21.5 -130 -28.0 +300
Sun (9/17) @ 1:03pm ET SEA Seahawks +5.5 -110 -5.5 -125 +2.5 -110 -2.5 -278 -2.5 -118 -3.0 +150
DET Lions -5.5 -110 +5.5 -105 -2.5 -120 +2.5 +215 +2.5 -110 +3.0 -189
Sun (9/17) @ 1:03pm ET IND Colts +1.5 -110 -10.5 -1000 -8.5 -714 -11.0 +400 -10.5 -114 -10.5 -141
HOU Texans -1.5 -110 +10.5 +600 +8.5 +425 +11.0 -588 +10.5 -115 +10.5 +110
Sun (9/17) @ 1:03pm ET KC Chiefs -2.5 -115 -11.5 +110 -7.5 -455 -7.5 -400 -7.5 -110 -11.0 0
JAX Jaguars +2.5 -105 +11.5 -141 +7.5 +310 +7.5 +290 +7.5 -118 +11.0 0
Sun (9/17) @ 1:05pm ET GB Packers -1.0 -110 -1.5 +850 -1.5 +210 +1.5 -149 -1.5 -233 +0.5 0
ATL Falcons +1.0 -110 +1.5 -1667 +1.5 -303 -1.5 +120 +1.5 +172 -0.5 0
Sun (9/17) @ 4:06pm ET NY Giants -4.5 -110 -3.5 +185 -2.5 -10000 +3.5 -125 -4.5 -112 +3.5 -108 +3.5 -105
ARI Cardinals +4.5 -110 +3.5 -244 +2.5 +1200 -3.5 -105 +4.5 -109 -3.5 -120 -3.5 -120
Sun (9/17) @ 4:06pm ET SF 49ers -6.5 -110 -9.5 -175 -7.5 -185 -9.5 -303 -7.0 -115 -9.5 -435 -10.5 +210
LA Rams +6.5 -110 +9.5 +135 +7.5 +140 +9.5 +230 +7.0 -108 +9.5 +300 +10.5 -278
Sun (9/17) @ 4:26pm ET NY Jets +3.0 -110 +19.5 +150 +20.5 -909 +20.5 -400 +8.5 -109 +19.5 +185 +19.5 +240
DAL Cowboys -3.0 -110 -19.5 -196 -20.5 +500 -20.5 +290 -8.5 -112 -19.5 -250 -19.5 -323
Sun (9/17) @ 4:27pm ET WAS Commanders +3.5 -110 -4.5 -208 -5.5 +115 -5.5 -105 +3.5 -110 -7.5 -667 -7.0 +110
DEN Broncos -3.5 -110 +4.5 +160 +5.5 -149 +5.5 -125 -3.5 -110 +7.5 +410 +7.0 -141
Sun (9/17) @ 8:25pm ET MIA Dolphins -2.5 -105 -6.5 -161 -6.5 -161 -13.5 -115 -2.0 -114 -6.5 -161 -13.5 -120
NE Patriots +2.5 -115 +6.5 +124 +6.5 +125 +13.5 -115 +2.0 -108 +6.5 +122 +13.5 -105
Mon (9/18) @ 7:19pm ET NO Saints -2.5 -115 -7.5 -135 -6.5 -278 -10.5 -189 -3.0 -114 -10.5 -175 -4.0 +110
CAR Panthers +2.5 -105 +7.5 +105 +6.5 +210 +10.5 +150 +3.0 -108 +10.5 +132 +4.0 -141
Mon (9/18) @ 8:20pm ET CLE Browns -1.5 -105 +4.5 -263 +3.5 +210 -2.5 -189 -2.5 -109 +3.5 +240 +3.5 +500
PIT Steelers +1.5 -115 -4.5 +195 -3.5 -303 +2.5 +150 +2.5 -112 -3.5 -333 -3.5 -833
Thu (9/14) @ 8:16pm ET MIN Vikings o48.5 -110 o56.5 -110 o62.5 +2500 o49.5 -110 o49.0 -110 o56.5 -114 o56.5 -105
PHI Eagles u48.5 -110 u56.5 -120 u62.5 -10000 u49.5 -110 u49.0 -110 u56.5 -114 u56.5 -120
Sun (9/17) @ 1:01pm ET BAL Ravens o45.5 -110 o50.5 -167 o51.5 +240 o45 -110 o45.0 -114 o50.5 -152 o50.5 -130
CIN Bengals u45.5 -110 u50.5 +130 u51.5 -345 u45 -110 u45.0 -108 u50.5 +116 u50.5 +105
Sun (9/17) @ 1:01pm ET LA Chargers o45.5 -110 o51.5 -263 o50.5 -10000 o45.5 -110 o45.5 -112 o44.5 -169 o44.5 -115
TEN Titans u45.5 -110 u51.5 +195 u50.5 +1750 u45.5 -110 u45.5 -109 u44.5 +130 u44.5 -110
Sun (9/17) @ 1:02pm ET CHI Bears o43.5 -110 o37.5 +124 o36.5 -154 o36.5 -164 o37.5 -112
TB Buccaneers u43.5 -110 u37.5 -161 u36.5 +120 u36.5 +125 u37.5 -112
Sun (9/17) @ 1:02pm ET LV Raiders u47.5 -110 u47.5 +140 u48.5 -714 u48.5 -185 u48 -145
BUF Bills o47.5 -110 o47.5 -179 o48.5 +425 o48.5 +140 o48 +115
Sun (9/17) @ 1:03pm ET SEA Seahawks u50.5 -110 u67.5 +270 u65.5 -125 u54.5 -110 u59.5 -145
DET Lions o50.5 -110 o67.5 -370 o65.5 -105 o54.5 -118 o59.5 +115
Sun (9/17) @ 1:03pm ET IND Colts u40.5 -110 u54.5 -120 u54.5 -115 u56.5 -110 u54.5 -120
HOU Texans o40.5 -110 o54.5 -110 o54.5 -115 o56.5 -118 o54.5 -105
Sun (9/17) @ 1:03pm ET KC Chiefs u50.5 -105 u32.5 -105 u26.5 -154 u50 -110 u32.5 -114 u30.5 0
JAX Jaguars o50.5 -115 o32.5 -125 o26.5 +120 o50 -110 o32.5 -115 o30.5 0
Sun (9/17) @ 1:05pm ET GB Packers u41.5 -110 u52.5 -130 u49.5 +100 u51.5 +100 u49 0
ATL Falcons o41.5 -110 o52.5 +100 o49.5 -130 o51.5 -130 o49 0
Sun (9/17) @ 4:06pm ET NY Giants u38.5 -110 u59.5 -145 u59.5 -2000 u39.5 -110 u39.5 -108 u58.5 +104 u51.5 +300
ARI Cardinals o38.5 -110 o59.5 +114 o59.5 +775 o39.5 -110 o39.5 -114 o58.5 -135 o51.5 -400
Sun (9/17) @ 4:06pm ET SF 49ers u42.5 -110 u53.5 -110 u53.5 -110 u45 -110 u45.0 -109 u53.5 -114 u50.5 -130
LA Rams o42.5 -110 o53.5 -120 o53.5 -115 o45 -110 o45.0 -112 o53.5 -114 o50.5 +105
Sun (9/17) @ 4:26pm ET NY Jets u45.5 -110 u46.5 -120 u43.5 -130 u38.5 -110 u38.5 -109 u46.5 -115 u40.5 -250
DAL Cowboys o45.5 -110 o46.5 -110 o43.5 +100 o38.5 -110 o38.5 -112 o46.5 -114 o40.5 +190
Sun (9/17) @ 4:27pm ET WAS Commanders u40.5 -110 u65.5 -149 u63.5 -105 u38.5 -109 u64.5 +106 u62 -112
DEN Broncos o40.5 -110 o65.5 +120 o63.5 -125 o38.5 -112 o64.5 -139 o62 -112
Sun (9/17) @ 8:25pm ET MIA Dolphins o45.5 -110 o40.5 -179 o41.5 -110 o46.5 -112 o41.5 +154 o41 +115
NE Patriots u45.5 -110 u40.5 +140 u41.5 -115 u46.5 -109 u41.5 -204 u41 -145
Mon (9/18) @ 7:19pm ET NO Saints u40.5 -110 u25.5 -200 u24.5 -141 u39.5 -110 u39.5 -109 u22.5 -106 u22.5 -141
CAR Panthers o40.5 -110 o25.5 +154 o24.5 +105 o39.5 -110 o39.5 -112 o22.5 -122 o22.5 +110
Mon (9/18) @ 8:20pm ET CLE Browns o42.5 -110 o50.5 -175 o48.5 -105 o39 -110 o38.5 -112 o48.5 +106 o48.5 -112
PIT Steelers u42.5 -110 u50.5 +135 u48.5 -125 u39 -110 u38.5 -109 u48.5 -139 u48.5 -112

NFL Week 2 Point Spreads and Totals 

Lines are via FanDuel as of Friday, Sept. 16. Always shop around the sports betting marketplace for the best odds for your wagers.

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Detroit is now favored against Washington in Week 2. (AP Photo/Paul Sancya)

Commanders at Lions (-1.5, 48.5)

This line flipped in favor of Detroit by three full points at FanDuel since Monday. The Lions have received 73% of the bets and 76% of the overall handle.

I was at Two Kings Sportsbook in North Carolina working on a story last week. One bettor identified this game as his best bet of the week on a look-ahead line that was pick ‘em at the time. He’d bet the Lions “all day” here.

Until Detroit actually wins a game, it’s hard to get too excited about the Lions.

Bengals (-7.5, 41.5) at Cowboys

More serious movement here after the line previously flipped from Cowboys -2.5 to Bengals -6.5 on the news that Dallas QB Dak Prescott needs surgery on his thumb and will miss several weeks. Bettors have pushed the Bengals to -7.5 and driven the total down to 41.5.

A total of 86% of the bets and 84% of the handle were on Cincinnati as of Friday morning.

Dolphins at Ravens (-3.5, 44.5)

Congratulations if you took Baltimore in your Survivor pool in Week 1 as teams like Indianapolis, Tennessee, and San Francisco found a way to disappoint.    

But looking ahead to this clash, it’s hard to forget what the Dolphins did to the Ravens last season. Miami’s defense smothered Lamar Jackson and made him look mortal in a 22-10 victory.

FanDuel bettors still believe in Baltimore as 80% of the betting handle is on the Ravens.

Jets at Browns (-6.5, 39.5)

The total for this game dropped a full point since Monday at FanDuel, where 85% of the handle and 72% of bets were on the under.

Southerners have a time-honored expression: “Bless your heart.” It’s often used disingenuously. Translation: You’re a hot mess. We truly feel for long-suffering fans of the Jets, who find new ways to disappoint every year.

Meanwhile, Cleveland’s defense is no joke and on offense it continues to run the ball with the league’s best. The Browns look like a solid Survivor pick in Week 2.  

Colts (-4.5, 45.5) at Jaguars

This line has moved down a full point from Monday to Indy -3.5. FanDuel bettors have pounded the over with 84% of the handle on it.

There’s always one you didn’t see coming, right? We wrote about the Wong Teaser last week and selected Indianapolis -2 over Houston along with Minnesota, which handled Green Bay with ease. 

There’s always a tendency to overreact in Week 2 of an NFL season, too, but Jacksonville +3.5 looks like a solid play anyway.

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Buccaneers (-2.5, 44.5) at Saints

Flip a coin on the side here? The betting handle for this NFC South matchup was split exactly down the middle at FanDuel.

The Saints owned the Bucs last year as they swept the season series, and dealt Tampa Bay two of its four losses during the regular season.

We used the Saints +8.5 and Steelers +7.5 in our Wong Teaser for NFL Week 2.  

Patriots (-2.5, 40.5) at Steelers  

Why is New England favored here? This line moved another 1.5 points in New England’s direction since Monday. FanDuel bettors don’t agree, either, as 78% of the bets are on Pittsburgh.

Steelers defensive stalwart T.J. Watt will miss this game with a torn pectoral muscle. 

Panthers at Giants (-1.5, 43.5)

The Giants were -2.5 at FanDuel on Monday, and the total was 42.5. The percentage of bets on both sides was fairly even at FanDuel as was the total as of Friday.

Also read: Week 1 betting recap

Falcons at Rams (-9.5, 46.5)

The Rams have a potential get-well game after stumbling against the Bills in the NFL season opener, but 60% of the bets at FanDuel are backing the Falcons with the points.

Matthew Stafford will look to rebound from a poor Week 1 performance that saw him throw three picks and just one TD. He failed to throw multiple TDs in just four games last season.

Maybe his elbow isn’t fully recovered, or perhaps he just needs to spend more time with this iteration of Sean McVay’s offense. 

LA was a double-digit favorite three times last season, and the Rams were 1-2 ATS in those games.    

Seahawks at 49ers (-8.5, 41.5) 

Tricky spot here, no? It’s difficult to take too much away from San Francisco’s season opener due to monsoon conditions in Chicago. Not keen on laying 8.5 points until Trey Lance proves himself at QB. FanDuel players are hammering the under at 91% of the handle on the total.

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Cardinals at Raiders (-5.5, 51.5)

This line jumped two points to Las Vegas -5.5 since the start of the week. The Raiders are the highly preferred side on the moneyline at FanDuel with 81% of the handle backing Las Vegas (-240 as of Friday).

Texans at Broncos (-9.5, 45.5)

Another game with fairly even money coming in on the side and total at FanDuel.

Houston was perhaps the biggest surprise in Week 1, taking Indianapolis to overtime before emerging with a hard-fought tie. But are the Texans worth taking as a big dog again in Denver? We’re not quite there yet.      

Bears at Packers (-9.5, 41.5) 

Yes, Aaron Rodgers has owned the Bears. But 61% of the bets on the spread have been on Chicago at FanDuel.

Chicago gave its fans a pleasant surprise in Week 1, and Green Bay looked like a hot mess against Minnesota. So, expect A-Rod to find a way to lead Green Bay to a double-digit cover on Sunday Night Football. Seriously, though, this game has stay away written all over it. 

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Titans at Bills (-9.5, 48.5)

Do yourself a solid and read the Sharp Report by Rob Miech on Gaming Today each week. As Miech noted in this week’s installment, sharp bettors jumped on the Titans early at +10.5 at the South Point in Las Vegas.

Did you know the underdog has won the last four games in this series? The two teams met last October with the Bills laying -6 on the road. The Titans won that game outright, 34-31.     

Vikings at Eagles (-2.5, 50.5)

The second of two MNF matchups this week features a pair of teams we’re bullish on in 2022. Philadelphia could be a sneaky good choice to win the NFC, and hopefully the Eagles were among your futures bets at the time this piece was published. They were down to +600 at FanDuel as of today.

Minnesota was +300 to win the NFC North at FanDuel in early August. The Vikings are now +130.

Also check: Super Bowl 57 odds

Who sets the NFL odds for Week 2?

Oddsmakers at sportsbooks such as DraftKings and BetMGM set the odds for NFL games. The odds are adjusted based on how patrons are betting, injuries, trades, and other key developments.

Who has the best NFL odds?

That depends on your bet. Always shop around the industry to compare the odds being offered at different sportsbooks before making your bet.

Is the favored team plus or minus?

The favorite team is listed as minus. For example, the Bills are -9.5 against the Titans in Week 2. That means Buffalo needs to win the game by 10 points to cover the spread.

Who is favored to win Super Bowl 57?

The Buffalo Bills are the betting favorite to win Super Bowl 57. FanDuel was dealing the Bills at +500 as of Monday, Sept. 12.

About the Author
Kris Johnson

Kris Johnson

Senior Writer
Kris Johnson is a senior writer at Gaming Today with more than 15 years of experience as a sports journalist. Johnson's work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and other publications. He also authored a sports betting novel titled The Endgame.

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