NFL Week 3 Betting Picks & Predictions: Targeting 2 Favorites and 1 Total

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The second week of the 2022 NFL season brought a flurry of excitement with last-minute, record-breaking comebacks. Cardinals, Jets, and Dolphins fans–and bettors–watched in disbelief as their teams orchestrated historic come-from-behind victories.

With NFL Week 3 on the horizon, there’s bound to be more excitement on deck. The third week poses a must-win scenario for teams on the brink of an 0-3 start and an opportunity for the six remaining unbeaten squads to prove they’re for real. In our NFL Week 3 predictions, find the best bets that offer value in what figures to be another crazy weekend of NFL action.

Chicago Bears vs. Houston Texans Betting Lines & Pick

The Bears are a standard home favorite. Here are live point spreads, totals, and moneylines from around the sports betting marketplace.

HOU Texans vs CHI Bears Odds NFL Odds

NFL · Sun (9/25) @ 1:02pm ET

HOU Texans at CHI Bears
Soldier Field, Chicago, Illinois

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After losing to divisional rival Green Bay at Lambeau Field on Sunday night, the Bears return to Soldier Field for a favorable matchup against Houston. The Texans failed to score a single touchdown last week against the Broncos in the first leg of back-to-back road games.

Chicago Bears RB David Montgomery
Chicago Bears running back David Montgomery (Photo by Robin Alam/Icon Sportswire)

Despite both teams entering the season with low expectations, it’s the team in the north that gets the edge in this inter-conference matchup. Playing the Bears as a short home favorite is one of the best bets of NFL Week 3.

Chicago pulled out a surprise win over the San Francisco 49ers to start the 2022 season. Despite their loss to Green Bay in Week 2, there are a few positives for the Bears to build off of going into this week.

They ran the ball well against the Packers before the deficit necessitated a pivot to the passing game. David Montgomery rushed for 122 yards, and quarterback Justin Fields added 20 yards and a touchdown on the ground.

The Bears rushing attack faces a Texans defense that has conceded the third-most rushing yards this season. Lovie Smith makes his first return to the windy city as a head coach since being let go by Chicago in 2012. Now leading the Texans, he returns with a 0-1-1 record in his first year in Houston.

Quarterback Davis Mills has been up and down through two games this year. Houston has held late leads in both of their games so far, but has been unable to finish the job with a win.

Both of these teams play ugly, but the Bears at home have the slight edge in this one. Expect the Bears to gameplan around Montgomery on the ground and utilize Fields’ legs and play action. As one of the best picks for Week 3, take the Bears to win and cover in a Soldier Field slugfest.

Pick: Chicago -3

Also read: Browns vs. Steelers Odds & TNF Prediction

Cincinnati Bengals vs. New York Jets Betting Lines and Pick

The Bengals are a healthy road favorite in a game they need to win badly.

CIN Bengals vs NY Jets Odds NFL Odds

NFL · Sun (9/25) @ 1:00pm ET

CIN Bengals at NY Jets
MetLife Stadium, East Rutherford, New Jersey

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It hasn’t been a good start to the season for last year’s Super Bowl runnerup. Cincinnati has dropped its first two games to the Pittsburgh Steelers and Dallas Cowboys–each by just a field goal.

The Bengals are primed to bounce back against the Jets who are coming off an improbable last-minute win over Cleveland. One of the best bets of NFL Week 3, take the Bengals laying five on the road.

New York had to rely on a couple of Browns miscues in the last two minutes of Sunday’s game to pull off the 31-30 win. Joe Burrow and the Bengals are a more talented team that won’t allow the Jets to overcome a 13-point deficit with 90 seconds left.

After losing their first two games, this is a must-win for the Bengals. Although the Jets’ new playmakers were on display on Sunday, the Bengals still boast the better roster and experience to pull off a resounding win.

The biggest concern for the Bengals continues to be pass protection. Despite vowing to address the offensive line after last year’s postseason, Burrow has been sacked a league-leading 13 times through two weeks. The Bengals, however, catch a break with a Jets defense that has notched only three sacks on the year.

With more time to throw, expect Burrow and wide receiver Ja’Marr Chase to get back on track against a Jets defense that has allowed the seventh-most yards per passing attempt.

Cincinnati has faced two of the most aggressive defenses in the league with the Steelers and Cowboys. They’ll have their easiest opponent yet with a road trip to MetLife Stadium.

The Jets are lucky to not be entering the game 0-2 and this spread is inflating last week’s Jets win and underestimating a winless Bengals squad. Take the Bengals to win by at least a touchdown in this best bet of NFL Week 3.

Pick: Cincinnati -5

Also read: NFL Week 3 Betting Trends

Denver Broncos vs. San Francisco 49ers Betting Line & Pick

This game looks like a grinder, and our eye is on the total here.

SF 49ers vs DEN Broncos Odds NFL Odds

NFL · Sun (9/25) @ 8:22pm ET

SF 49ers at DEN Broncos
Empower Field at Mile High, Denver, Colorado

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Jimmy Garappolo replaces the injured Trey Lance behind center for San Francisco as the 49ers head to Mile High to take on the Broncos. Neither team has been impressive on the offensive side of the ball through two games.

The under with these two struggling teams is one of the best bets of NFL Week 3.

Denver traded for Russell Wilson in the offseason with the expectation that the former Seahawk will lead the Broncos to the next level. Wilson has been pedestrian thus far, tossing just two touchdown passes to one interception with a modest 86.5 QB rating.

The Broncos have averaged only 16 points per game – ninth worst in the league – despite their first two games coming against teams who finished 2021 near the bottom in most defensive categories.

Wilson has his toughest challenge yet with a stout 49ers defense. San Francisco has performed well in limiting opposing offenses, allowing only 13 points per game and a league-best 210 yards per game. Wilson has an uphill battle and his top receiver, Jerry Jeudy, is day-to-day with a rib injury.

The 49ers offense hasn’t performed well either. Garappolo’s experience may increase the team’s efficiency somewhat, but he lacks the ability to stretch the ball down the field. Through two weeks, the 49ers are 20th in points per game. The 49ers offense faces a tough defense that will limit their ability to score–Denver has also allowed only 13 points per game, tied with the 49ers for the third-best in the league.

San Francisco and Denver have both been dominating the time of possession, posting the second- and sixth-best times in the league, respectively. Long, methodical drives by both teams will limit scoring opportunities. Stingy defenses will keep the offenses from scoring touchdowns and this matchup may come down to a game of field goals.

The under here is one of the best bets of NFL Week 3 as all signs point to a low-scoring affair.

Pick: Under 45

Also read: NFL Week 4 Look-Ahead Lines

About the Author
Ken Bates

Ken Bates

Ken Bates is a contributor to Gaming Today. With years of experience in the sports betting industry, he’s covered several sports and is always on the lookout for an angle to bet. He resides in upstate New York and, as difficult as it may sometimes be, roots for the Jets, Mets, and Islanders.

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