NFL Week 4 Odds: Brady Vs. Belichick, NFC West Showdowns, And Largest Line Of Season Highlight Betting Slate

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Week 4 of the 2021 NFL season kicked off with the Bengals beating the Jaguars 24-21 on a field goal in the closing seconds Thursday night, but Jacksonville comfortably covering the spread as a 7.5-point underdog.

In Sunday action, while Buccaneers vs. Patriots is getting a lot of the buzz, we also have our eyes on two games pitting NFC West rivals against each other, a rematch of Super Bowl XLV, and the Bills laying the largest point spread of the season so far.

Monday night features a key showdown in the AFC West.

Live Week 4 Sportsbook Odds

Bet TypeSpreads
Open
Thu (9/30) @ 8:22pm ET JAX Jaguars +260 +385 +135 +375 +275 +420 +500
CIN Bengals -345 -588 -164 -500 -333 -588 -714
Sun (10/3) @ 1:00pm ET WAS Washington -115 -3333 +160 0 -123 0 0
ATL Falcons +100 +1200 -200 +3000 +110 +4000 0
Sun (10/3) @ 1:00pm ET HOU Texans +875 +10000 +3300 +6000 +950 +4000 +1550
BUF Bills -1429 0 -10000 0 -1429 0 -3333
Sun (10/3) @ 1:00pm ET DET Lions +155 +10000 +400 +4500 +130 +8000 0
CHI Bears -185 0 -556 0 -147 0 0
Sun (10/3) @ 1:00pm ET CAR Panthers +160 +10000 +600 +4500 +175 +2500 +690
DAL Cowboys -189 0 -1000 0 -200 -10000 -1000
Sun (10/3) @ 1:00pm ET IND Colts +105 0 -2000 0 +123 0 0
MIA Dolphins -125 +5000 +900 +5000 -143 +8000 0
Sun (10/3) @ 1:00pm ET CLE Browns -110 -5000 -1667 0 -108 -5000 0
MIN Vikings -105 +1500 +800 +3500 -105 +1600 0
Sun (10/3) @ 1:00pm ET NY Giants +225 -3333 -161 -145 +280 -145 0
NO Saints -278 +1300 +135 +115 -333 +118 0
Sun (10/3) @ 1:00pm ET TEN Titans -345 -130 +140 -110 -263 +2500 0
NY Jets +290 +100 -175 -120 +220 -10000 0
Sun (10/3) @ 1:00pm ET KC Chiefs -250 0 -10000 0 -357 0 0
PHI Eagles +210 +10000 +3300 +4500 +290 +8000 0
Sun (10/3) @ 4:05pm ET ARI Cardinals +190 0 -667 0 +175 0 0
LA Rams -227 +10000 +425 +4000 -200 +8000 0
Sun (10/3) @ 4:05pm ET SEA Seahawks +140 -10000 -833 -10000 +116 -10000 0
SF 49ers -164 +2500 +550 +2800 -135 +1800 0
Sun (10/3) @ 4:25pm ET BAL Ravens -110 0 -10000 0 +102 0 0
DEN Broncos -105 +4000 +1400 +6000 -115 +8000 0
Sun (10/3) @ 4:25pm ET PIT Steelers +210 +7000 +600 +6000 +220 +8000 +2500
GB Packers -250 0 -1000 0 -263 0 -10000
Sun (10/3) @ 8:20pm ET TB Buccaneers -227 -200 +150 -2000 -278 -189 0
NE Patriots +190 +160 -185 +1000 +235 +152 0
Mon (10/4) @ 8:50pm ET LV Raiders +140 +1600 +230 +6000 +145 +8000 0
LA Chargers -164 -5000 -303 0 -164 0 0
Thu (9/30) @ 8:22pm ET JAX Jaguars +2.5 -110 -1.5 -110 +2.5 +105 +3.5 -238 +7.0 -105 +3.5 -278 +2.5 0
CIN Bengals -2.5 -110 +1.5 -120 -2.5 -130 -3.5 +195 -7.0 -109 -3.5 +210 -2.5 0
Sun (10/3) @ 1:00pm ET WAS Washington -1.5 -110 +1.5 -105 +5.5 +120 -4.0 +150 -2.0 -109 -3.5 0 +7.0 0
ATL Falcons +1.5 -110 -1.5 -125 -5.5 -145 +4.0 -179 +2.0 -112 +3.5 +1200 -7.0 0
Sun (10/3) @ 1:00pm ET HOU Texans +16.5 -110 +33.5 -161 +39.5 +450 +40.0 +240 +18.0 -110 +39.5 +540 +39.0 0
BUF Bills -16.5 -110 -33.5 +130 -39.5 -1000 -40.0 -303 -18.0 -110 -39.5 -909 -39.0 0
Sun (10/3) @ 1:00pm ET DET Lions +3.5 -110 +3.5 -115 +3.5 -105 +10.0 -125 +2.5 -105 +10.5 -10000 +7.0 0
CHI Bears -3.5 -110 -3.5 -115 -3.5 -115 -10.0 -105 -2.5 -118 -10.5 +1200 -7.0 0
Sun (10/3) @ 1:00pm ET CAR Panthers +4.0 -110 +17.5 -110 +10.5 -105 +8.0 +140 +4.0 -108 +8.5 -909 +14.5 0
DAL Cowboys -4.0 -110 -17.5 -120 -10.5 -115 -8.0 -169 -4.0 -114 -8.5 +520 -14.5 0
Sun (10/3) @ 1:00pm ET IND Colts +1.5 -110 -10.5 +150 -10.5 +165 -13.5 +120 +3.0 -109 -13.5 -106 -9.5 0
MIA Dolphins -1.5 -110 +10.5 -185 +10.5 -200 +13.5 -149 -3.0 -104 +13.5 -120 +9.5 0
Sun (10/3) @ 1:00pm ET CLE Browns -1.0 -110 -6.5 -135 -6.5 -455 -7.0 +105 -0.5 -110 -6.5 -10000 -8.0 0
MIN Vikings +1.0 -110 +6.5 +105 +6.5 +350 +7.0 -135 +0.5 -110 +6.5 +1200 +8.0 0
Sun (10/3) @ 1:00pm ET NY Giants +6.5 -110 +3.0 +110 +3.5 -161 +2.5 +110 +7.0 -108 -2.5 -159 +10.5 0
NO Saints -6.5 -110 -3.0 -141 -3.5 +135 -2.5 -141 -7.0 -106 +2.5 +124 -10.5 0
Sun (10/3) @ 1:00pm ET TEN Titans -7.5 -105 +0.5 -667 +6.5 -110 +0.5 -135 -5.5 -110 +3.5 0 +6.0 0
NY Jets +7.5 -115 -0.5 +425 -6.5 -110 -0.5 +105 +5.5 -105 -3.5 +1200 -6.0 0
Sun (10/3) @ 1:00pm ET KC Chiefs -6.5 -110 -18.5 -263 -8.5 -105 -12.0 +225 -7.0 -108 -11.5 -227 -9.5 0
PHI Eagles +6.5 -110 +18.5 +200 +8.5 -115 +12.0 -278 +7.0 -108 +11.5 +172 +9.5 0
Sun (10/3) @ 4:05pm ET ARI Cardinals +5.5 -110 -23.5 -141 -9.5 -110 -17.0 +800 +3.5 -110 -16.5 -5000 -21.0 0
LA Rams -5.5 -110 +23.5 +110 +9.5 -110 +17.0 -1429 -3.5 -110 +16.5 +1200 +21.0 0
Sun (10/3) @ 4:05pm ET SEA Seahawks +3.5 -120 -14.5 -227 -8.5 +120 -7.0 -455 +2.5 -112 -6.5 -3333 -13.5 0
SF 49ers -3.5 +100 +14.5 +175 +8.5 -145 +7.0 +340 -2.5 -109 +6.5 +1060 +13.5 0
Sun (10/3) @ 4:25pm ET BAL Ravens -1.0 -105 -13.5 -200 -15.5 -455 -16.0 +2000 +1.0 -108 -15.5 -192 -16.0 0
DEN Broncos +1.0 -115 +13.5 +160 +15.5 +360 +16.0 -5000 -1.0 -114 +15.5 +150 +16.0 0
Sun (10/3) @ 4:25pm ET PIT Steelers +6.0 -110 +9.5 +340 +10.5 -278 +10.0 -500 +6.0 -108 +9.5 +400 +15.5 0
GB Packers -6.0 -110 -9.5 -500 -10.5 +230 -10.0 +375 -6.0 -106 -9.5 -625 -15.5 0
Sun (10/3) @ 8:20pm ET TB Buccaneers -3.0 -120 -2.5 -105 +0.5 -105 -2.0 +170 -6.5 -108 -1.5 -161 -2.5 -110
NE Patriots +3.0 +100 +2.5 -125 -0.5 -115 +2.0 -208 +6.5 -108 +1.5 +126 +2.5 -110
Mon (10/4) @ 8:50pm ET LV Raiders +3.0 +100 +13.5 +360 +4.5 -141 +14.0 -169 +3.5 -114 +13.5 +630 +8.5 0
LA Chargers -3.0 -120 -13.5 -556 -4.5 +115 -14.0 +140 -3.5 -103 -13.5 -1250 -8.5 0
Thu (9/30) @ 8:22pm ET JAX Jaguars u47 -110 u49.5 -130 u44.5 -110 u46.0 -108 u45.5 -135 u49.5 0
CIN Bengals o47 -110 o49.5 +100 o44.5 -110 o46.0 -114 o45.5 +106 o49.5 0
Sun (10/3) @ 1:00pm ET WAS Washington u48.5 -110 u61.5 -115 u60.5 -110 u47 -110 u47.5 -114 u64.5 0 u61 0
ATL Falcons o48.5 -110 o61.5 -115 o60.5 -110 o47 -110 o47.5 -108 o64.5 +1000 o61 0
Sun (10/3) @ 1:00pm ET HOU Texans u49 -110 u39.5 +130 u30.5 -115 u47.5 -110 u47.0 -110 u40.5 -400 u38 0
BUF Bills o49 -110 o39.5 -161 o30.5 -105 o47.5 -110 o47.0 -110 o40.5 +285 o38 0
Sun (10/3) @ 1:00pm ET DET Lions u44 -110 u45.5 -135 u46.5 -141 u41.5 -110 u41.5 -110 u38.5 0 u45 0
CHI Bears o44 -110 o45.5 +105 o46.5 +115 o41.5 -110 o41.5 -110 o38.5 0 o45 0
Sun (10/3) @ 1:00pm ET CAR Panthers o50.5 -110 o64 -105 o65.5 -154 o51.5 -110 o51.5 -110 o64.5 +186 o61.5 -105
DAL Cowboys u50.5 -110 u64 -125 u65.5 +125 u51.5 -110 u51.5 -110 u64.5 -244 u61.5 -115
Sun (10/3) @ 1:00pm ET IND Colts o43.5 -110 o44.5 +105 o44.5 +150 o42 -110 o41.5 -114 o50.5 -118 o42 -110
MIA Dolphins u43.5 -110 u44.5 -135 u44.5 -185 u42 -110 u41.5 -108 u50.5 -108 u42 -110
Sun (10/3) @ 1:00pm ET CLE Browns o50.5 -135 o28 -120 o21.5 +300 o51.5 -110 o51.5 -108 o21.5 +1000 o25 0
MIN Vikings u50.5 +110 u28 -110 u21.5 -370 u51.5 -110 u51.5 -114 u21.5 -5000 u25 0
Sun (10/3) @ 1:00pm ET NY Giants u47 -110 u37.5 -105 u44.5 -149 u42.5 -110 u42.5 -108 u45.5 -135 u38.5 0
NO Saints o47 -110 o37.5 -125 o44.5 +125 o42.5 -110 o42.5 -114 o45.5 +106 o38.5 0
Sun (10/3) @ 1:00pm ET TEN Titans u46 -110 u50.5 +110 u50.5 +115 u44.5 -110 u44.5 -114 u51.5 0 u50.5 0
NY Jets o46 -110 o50.5 -141 o50.5 -141 o44.5 -110 o44.5 -108 o51.5 +1000 o50.5 0
Sun (10/3) @ 1:00pm ET KC Chiefs o54.5 -110 o65 -164 o64.5 -164 o54 -110 o53.5 -114 o72.5 +162 o64.5 -110
PHI Eagles u54.5 -110 u65 +135 u64.5 +140 u54 -110 u53.5 -108 u72.5 -208 u64.5 -110
Sun (10/3) @ 4:05pm ET ARI Cardinals o53.5 -110 o59.5 -115 o60.5 -105 o54 -110 o54.0 -112 o57.5 +1000 o60.5 -105
LA Rams u53.5 -110 u59.5 -115 u60.5 -115 u54 -110 u54.0 -109 u57.5 -5000 u60.5 -115
Sun (10/3) @ 4:05pm ET SEA Seahawks u49.5 -110 u48 -115 u46.5 +100 u52 -110 u52.0 -110 u49.5 -5000 u48.5 0
SF 49ers o49.5 -110 o48 -115 o46.5 -120 o52 -110 o52.0 -110 o49.5 +1000 o48.5 0
Sun (10/3) @ 4:25pm ET BAL Ravens o45 -110 o34 -141 o40.5 -120 o44 -110 o44.0 -114 o30.5 +215 o35.5 0
DEN Broncos u45 -110 u34 +110 u40.5 +100 u44 -110 u44.0 -108 u30.5 -294 u35.5 0
Sun (10/3) @ 4:25pm ET PIT Steelers u48 -115 u44 -120 u47.5 -130 u45 -110 u45.5 -114 u44.5 -345 u46.5 0
GB Packers o48 -105 o44 -110 o47.5 +105 o45 -110 o45.5 -108 o44.5 +255 o46.5 0
Sun (10/3) @ 8:20pm ET TB Buccaneers u49 -110 u36 -110 u35.5 +120 u49 -110 u49.5 -110 u38.5 +100 u37 0
NE Patriots o49 -110 o36 -120 o35.5 -145 o49 -110 o49.5 -110 o38.5 -130 o37 0
Mon (10/4) @ 8:50pm ET LV Raiders o52.5 -110 o45 -120 o46.5 +100 o52.0 -112 o42.5 +430 o44.5 0
LA Chargers u52.5 -110 u45 -110 u46.5 -120 u52.0 -109 u42.5 -667 u44.5 0

NFL Week 4 Lines & Early Moves

Here are consensus point spreads and totals for Week 4, updated Friday afternoon.

Jaguars at Bengals (-7.5, 45.5)

DraftKings‘ original look-ahead line of Cincinnati -4.5 proved far too cheap, as the number was bet to -6 last week and reposted -7.5 Sunday night.

Washington (-1.5, 47.5) at Falcons

The line here has flipped since Atlanta -1 was the most common number in early wagering, while the total was bet down from 48.5

Texans at Bills (-17.5, 47)

A Josh Allen-led 22-point blowout over Washington, combined with an 0-3 Texans team that will again trot out third-string QB Davis Mills, gives us the largest point spread of the season so far. The line has ranged from 16.5 to 18 in early wagering, and the total has dipped from 48.

Lions at Bears (-3 even, 41.5)

Underdog bettors grabbed the opening number of Lions +3.5, and the total plummeted from 44. Chicago coach Matt Nagy says he’ll make a game-time decision on the team’s starter at QB.

Colts at Dolphins (-2, 42.5)

While early sentiment on the dog, at Indy +2.5 and +2, moved the line to 1.5, it has since moved back toward Miami, with a few shops dealing 2.5. Here’s another game with a downward-trending total.

Browns (-2, 51.5) at Vikings

We’re seeing Vikings +2.5 on some boards, while WynnBET is dealing Browns -1.5 as of this Friday update. The total opened 52.5.

Giants at Saints (-7, 42)

New Orleans’ impressive showing in a 28-13 win in New England helped push this line from 6.5 in advanced wagering to -8, but that number was too big for the market’s tastes. So too was the earlier total of 43.5.

Titans (-6.5, 44.5) at Jets

The Titans are expected to be without starting wide receivers A.J. Brown and Julio Jones, and the spread has shrunk from 7.5. Some books, including FanDuel, are dealing -6. The total is also on its way down from as high as 47 in earlier wagering.

Chiefs (-7, 54.5) at Eagles

Kansas City opened -5.5 but reopened -7.5 after Philadelphia’s poor performance as 3-point dogs in Dallas on Monday night. While the hook has enticed dog bettors, Chiefs -6.5 is the most popular pick this week in our Bookies Battle contest.

Panthers at Cowboys (-4.5, 51.5)

Christian McCaffrey is among the few running backs whose absence impacts a betting line, and we’ve seen this number drift since 3.5 was hung last week. There’s been a point of resistance, though, as this week’s opening number of Dallas -5 didn’t last long against the unbeaten Panthers. Meanwhile, there’s been a move toward the OVER, as the total opened 50.

Cardinals at Rams (-4, 54.5)

Early interest has been on the dog, as the line has been bet down from 6. The total has been adjusted upward from 53.5 ahead of this battle of unbeatens.

49ers at Seahawks (-3 even, 52)

This number ranged from 2.5 to 3.5 in advanced wagering, as these divisional foes look to shake off Week 3 losses.

Ravens (-1, 44.5) at Broncos

The favorite has flipped twice here — Ravens -2.5 was hung on look-ahead oddsboards last week, while Sunday night’s opening price of Denver -2.5 drew interest in the underdog.

Steelers at Packers (-6.5, 45.5)

The Steelers are getting healthier, and dog and UNDER money has prompted moves from Green Bay -7 and 47.

Bucs (-7, 49) at Patriots

DraftKings’ look-ahead number was Bucs -3 (-120); if you got down on Tampa at that price, well done. The Sunday night opening line was Tampa -6, which looks pretty good now, too. There’s been some erosion in the betting market’s confidence in New England after rookie QB Mac Jones’ three-interception game against the Saints.

Raiders at Chargers (-3/-120, 51.5)

A small early market lean toward Los Angeles in this AFC West battle, the line moving from -3 in advanced wagering to -3 (-120).

Check out updated Super Bowl odds 2022.

About the Author

Marcus DiNitto

Marcus DiNitto is a nationally recognized editor and writer specializing in sports betting and sports business. He is the editor for Louisiana Sharp. He has been managing editor at SportsBusiness Daily, USA Sports Gaming, Sporting News and The Linemakers. Marcus earned his MBA from the University of North Carolina-Charlotte.

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