NFL Week 4 Odds: Brady Vs. Belichick, NFC West Showdowns, And Largest Line Of Season Highlight Betting Slate

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Week 4 of the 2021 NFL season kicked off with the Bengals beating the Jaguars 24-21 on a field goal in the closing seconds Thursday night, but Jacksonville comfortably covering the spread as a 7.5-point underdog.

In Sunday action, while Buccaneers vs. Patriots is getting a lot of the buzz, we also have our eyes on two games pitting NFC West rivals against each other, a rematch of Super Bowl XLV, and the Bills laying the largest point spread of the season so far.

Monday night features a key showdown in the AFC West.

Live Week 4 Sportsbook Odds

Bet TypeSpreads
Open
Thu (9/29) @ 8:15pm ET MIA Dolphins +120 +250 +3300 +4500 +10000 +2800
CIN Bengals -145 -323 -10000 0 0 -10000
Sun (10/2) @ 9:28am ET MIN Vikings -161 -1667 -10000 -1250 -2500 -769
NO Saints +135 +900 +1700 +750 +900 +500
Sun (10/2) @ 1:00pm ET CLE Browns -149 -130 +525 +400 -120 +3500 0
ATL Falcons +125 +100 -1000 -556 +105 0 0
Sun (10/2) @ 1:00pm ET WAS Commanders +140 +2500 +3300 +1400 +143 +10000 +2000
DAL Cowboys -164 0 -10000 -5000 -164 0 -10000
Sun (10/2) @ 1:00pm ET TEN Titans +155 -5000 -5000 -1667 +175 -10000 -10000
IND Colts -185 +1300 +1350 +850 -200 +1500 +2800
Sun (10/2) @ 1:02pm ET JAX Jaguars +260 +1500 +3300 +2000 +8000 0
PHI Eagles -345 -10000 -10000 -5000 0 0
Sun (10/2) @ 1:02pm ET NY Jets +165 +125 +200 +180 +114 +160
PIT Steelers -200 -154 -278 -222 -147 -189
Sun (10/2) @ 1:02pm ET BUF Bills -164 -1667 -455 -1000 -1250 -1111
BAL Ravens +140 +850 +300 +625 +630 +700
Sun (10/2) @ 1:02pm ET SEA Seahawks +225 -278 -345 -303 -278 -161
DET Lions -278 +220 +250 +240 +210 +135
Sun (10/2) @ 1:02pm ET CHI Bears +125 +850 +825 +6000 +10000 +7000
NY Giants -149 -1667 -2000 0 0 0
Sun (10/2) @ 1:02pm ET LA Chargers -278 -263 -10000 -345 0 0
HOU Texans +225 +210 +3300 +270 +10000 0
Sun (10/2) @ 4:05pm ET ARI Cardinals +105 -105 -105 -110 +100 -112 +100
CAR Panthers -125 -115 -115 -110 -114 -104 -115
Sun (10/2) @ 4:25pm ET NE Patriots +340 +350 +340 +360 +365 +360 +400
GB Packers -455 -435 -455 -476 -455 -455 -556
Sun (10/2) @ 4:25pm ET DEN Broncos +105 +130 +125 +122 +128 +120 +120
LV Raiders -125 -149 -149 -145 -143 -143 -141
Sun (10/2) @ 8:20pm ET KC Chiefs -145 +105 +110 +115 +104 +112 +110
TB Buccaneers +120 -125 -130 -135 -120 -132 -125
Mon (10/3) @ 8:15pm ET LA Rams +105 +105 +105 +105 +105 +104 +105
SF 49ers -125 -125 -125 -125 -122 -122 -120
Thu (9/29) @ 8:15pm ET MIA Dolphins +2.5 -110 +10.5 +530 +10.5 +475 +12.0 +1100 +12.5 0 +4.0 -108
CIN Bengals -2.5 -110 -10.5 -769 -10.5 -833 -12.0 -2500 -12.5 +4000 -4.0 -108
Sun (10/2) @ 9:28am ET MIN Vikings -3.0 -110 +2.5 +105 +2.5 +105 -2.5 -10000 -3.0 +175
NO Saints +3.0 -110 -2.5 -141 -2.5 -135 +2.5 +1600 +3.0 -208
Sun (10/2) @ 1:00pm ET CLE Browns -3.0 -105 -2.5 -141 -2.5 -141 -2.5 -149 -1.0 -114 +2.5 +7000 -3.0 +120
ATL Falcons +3.0 -115 +2.5 +110 +2.5 +105 +2.5 +120 +1.0 -108 -2.5 0 +3.0 -141
Sun (10/2) @ 1:00pm ET WAS Commanders +3.0 -110 +15.0 -175 +12.5 +185 +15.0 +110 +3.0 -108 +15.5 +168 +15.0 +160
DAL Cowboys -3.0 -110 -15.0 +140 -12.5 -250 -15.0 -141 -3.0 -114 -15.5 -227 -15.0 -189
Sun (10/2) @ 1:00pm ET TEN Titans +3.5 -110 -6.5 -115 -6.5 -149 -7.0 -588 +4.0 -114 -6.5 -2500 -7.0 0
IND Colts -3.5 -110 +6.5 -115 +6.5 +115 +7.0 +420 -4.0 -108 +6.5 +900 +7.0 0
Sun (10/2) @ 1:02pm ET JAX Jaguars +7.0 -110 +7.5 +255 +7.5 +1100 +8.5 -179 +8.5 -213 +8.5 -175
PHI Eagles -7.0 -110 -7.5 -323 -7.5 -5000 -8.5 +150 -8.5 +162 -8.5 +145
Sun (10/2) @ 1:02pm ET NY Jets +3.5 -110 +6.5 +100 +1.5 +180 +6.5 -115 +2.5 +104 +6.5 -120
PIT Steelers -3.5 -110 -6.5 -130 -1.5 -250 -6.5 -115 -2.5 -135 -6.5 +105
Sun (10/2) @ 1:02pm ET BUF Bills -3.0 -110 +2.5 +110 +2.5 +105 +2.5 +120 -3.5 -114 +2.5 +115
BAL Ravens +3.0 -110 -2.5 -141 -2.5 -141 -2.5 -149 +3.5 -114 -2.5 -135
Sun (10/2) @ 1:02pm ET SEA Seahawks +6.0 -110 -3.0 -110 -3.5 +110 -3.5 +185 -2.5 -278 -4.5 -120
DET Lions -6.0 -110 +3.0 -120 +3.5 -145 +3.5 -233 +2.5 +205 +4.5 +105
Sun (10/2) @ 1:02pm ET CHI Bears +3.0 -110 +7.5 +135 +7.5 +150 +7.5 +165 +8.5 0 +8.0 -145
NY Giants -3.0 -110 -7.5 -164 -7.5 -200 -7.5 -200 -8.5 +4000 -8.0 +125
Sun (10/2) @ 1:02pm ET LA Chargers -6.5 -110 -10.0 -179 -10.5 +600 -10.5 +800 -9.5 0 -3.0 +105
HOU Texans +6.5 -110 +10.0 +145 +10.5 -1111 +10.5 -556 +9.5 +2500 +3.0 -120
Sun (10/2) @ 4:05pm ET ARI Cardinals +1.5 -110 +1.0 -110 +1.0 -110 +1.0 -110 +1.0 -109 +1.0 -114 +1.0 -105
CAR Panthers -1.5 -110 -1.0 -110 -1.0 -110 -1.0 -110 -1.0 -112 -1.0 -106 -1.0 -110
Sun (10/2) @ 4:25pm ET NE Patriots +10.0 -110 +9.5 -110 +9.5 -110 +9.5 -110 +9.5 -109 +9.5 -108 +9.5 -105
GB Packers -10.0 -110 -9.5 -110 -9.5 -110 -9.5 -110 -9.5 -112 -9.5 -112 -9.5 -110
Sun (10/2) @ 4:25pm ET DEN Broncos +2.0 -110 +2.5 +100 +2.5 -105 +2.5 +100 +2.5 -106 +2.5 -114 +2.5 -105
LV Raiders -2.0 -110 -2.5 -120 -2.5 -115 -2.5 -120 -2.5 -115 -2.5 -106 -2.5 -110
Sun (10/2) @ 8:20pm ET KC Chiefs -2.5 -110 +2.0 -110 +1.5 -110 +2.0 -110 +1.5 -112 +1.5 -106 +2.0 -110
TB Buccaneers +2.5 -110 -2.0 -110 -1.5 -110 -2.0 -110 -1.5 -109 -1.5 -114 -2.0 -105
Mon (10/3) @ 8:15pm ET LA Rams +2.0 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -105
SF 49ers -2.0 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110
Thu (9/29) @ 8:15pm ET MIA Dolphins u47.5 -105 u41 -130 u42.5 -667 u42.5 0 u41 -108
CIN Bengals o47.5 -115 o41 +100 o42.5 +400 o42.5 +2200 o41 -108
Sun (10/2) @ 9:30am ET MIN Vikings o46.5 -110 o41.5 -105 o41.5 -110 o41.5 -112
NO Saints u46.5 -110 u41.5 -115 u41.5 -110 u41.5 -109
Sun (10/2) @ 1:00pm ET CLE Browns u46.5 -110 u47 -110 u46.5 +110 u48.5 -110 u48.5 -109 u43.5 0 u46.5 +125
ATL Falcons o46.5 -110 o47 -120 o46.5 -145 o48.5 -110 o48.5 -112 o43.5 +7000 o46.5 -145
Sun (10/2) @ 1:00pm ET WAS Commanders u42.5 -110 u38.5 +100 u35.5 -200 u41 -110 u41.0 -112 u35.5 -2000 u35.5 -115
DAL Cowboys o42.5 -110 o38.5 -130 o35.5 +165 o41 -110 o41.0 -109 o35.5 +790 o35.5 +100
Sun (10/2) @ 1:00pm ET TEN Titans u43.5 -110 u51 -120 u49.5 -130 u43 -110 u43.0 -114 u41.5 -909 u48 0
IND Colts o43.5 -110 o51 -110 o49.5 +105 o43 -110 o43.0 -108 o41.5 +530 o48 0
Sun (10/2) @ 1:02pm ET JAX Jaguars o47.5 -115 o50.5 +240 o53.5 +950 o50.5 +120 o55.5 -115
PHI Eagles u47.5 -105 u50.5 -303 u53.5 -3333 u50.5 -156 u55.5 +100
Sun (10/2) @ 1:02pm ET NY Jets o41.5 -110 o39 -115 o39.5 -125 o43.5 +148 o40 -108
PIT Steelers u41.5 -110 u39 -115 u39.5 -105 u43.5 -196 u40 -108
Sun (10/2) @ 1:02pm ET BUF Bills u53.5 -110 u50.5 -135 u50.5 -135 u46.5 +162 u50 +110
BAL Ravens o53.5 -110 o50.5 +105 o50.5 +110 o46.5 -213 o50 -130
Sun (10/2) @ 1:02pm ET SEA Seahawks u49.5 -115 u85.5 -105 u84.5 -115 u84.5 +100 u83.5 +125
DET Lions o49.5 -105 o85.5 -125 o84.5 -115 o84.5 -130 o83.5 -145
Sun (10/2) @ 1:02pm ET CHI Bears o39.5 -110 o35 +100 o36.5 -105 o32.5 +2800 o35 +100
NY Giants u39.5 -110 u35 -130 u36.5 -125 u32.5 0 u35 -115
Sun (10/2) @ 1:02pm ET LA Chargers u46.5 -110 u58 -149 u58.5 -500 u58.5 -10000 u57 +100
HOU Texans o46.5 -110 o58 +120 o58.5 +360 o58.5 +1600 o57 -115
Sun (10/2) @ 4:05pm ET ARI Cardinals o44.5 -110 o44 -110 o43.5 -110 o44 -110 o43.5 -108 o44.5 -106 o43.5 -110
CAR Panthers u44.5 -110 u44 -110 u43.5 -110 u44 -110 u43.5 -114 u44.5 -114 u43.5 -105
Sun (10/2) @ 4:25pm ET NE Patriots u42.5 -110 u40 -110 u40 -105 u40 -110 u40.5 -114 u39.5 -106 u40.5 -108
GB Packers o42.5 -110 o40 -110 o40 -115 o40 -110 o40.5 -108 o39.5 -114 o40.5 -108
Sun (10/2) @ 4:25pm ET DEN Broncos o44 -110 o46 -110 o45.5 -110 o45.5 -110 o45.5 -112 o45.5 -105 o45.5 -108
LV Raiders u44 -110 u46 -110 u45.5 -110 u45.5 -110 u45.5 -109 u45.5 -115 u45.5 -108
Sun (10/2) @ 8:20pm ET KC Chiefs o46.5 -110 o46.5 -110 o46.5 -110 o46.5 -110 o47.0 -110 o46.5 -118 o46.5 -108
TB Buccaneers u46.5 -110 u46.5 -110 u46.5 -110 u46.5 -110 u47.0 -110 u46.5 -104 u46.5 -108
Mon (10/3) @ 8:15pm ET LA Rams o44 -110 o42.5 -110 o42.5 -110 o42 -110 o42.5 -112 o42.5 -110 o42.5 -108
SF 49ers u44 -110 u42.5 -110 u42.5 -110 u42 -110 u42.5 -109 u42.5 -110 u42.5 -108

NFL Week 4 Lines & Early Moves

Here are consensus point spreads and totals for Week 4, updated Friday afternoon.

Jaguars at Bengals (-7.5, 45.5)

DraftKings‘ original look-ahead line of Cincinnati -4.5 proved far too cheap, as the number was bet to -6 last week and reposted -7.5 Sunday night.

Washington (-1.5, 47.5) at Falcons

The line here has flipped since Atlanta -1 was the most common number in early wagering, while the total was bet down from 48.5

Texans at Bills (-17.5, 47)

A Josh Allen-led 22-point blowout over Washington, combined with an 0-3 Texans team that will again trot out third-string QB Davis Mills, gives us the largest point spread of the season so far. The line has ranged from 16.5 to 18 in early wagering, and the total has dipped from 48.

Lions at Bears (-3 even, 41.5)

Underdog bettors grabbed the opening number of Lions +3.5, and the total plummeted from 44. Chicago coach Matt Nagy says he’ll make a game-time decision on the team’s starter at QB.

Colts at Dolphins (-2, 42.5)

While early sentiment on the dog, at Indy +2.5 and +2, moved the line to 1.5, it has since moved back toward Miami, with a few shops dealing 2.5. Here’s another game with a downward-trending total.

Browns (-2, 51.5) at Vikings

We’re seeing Vikings +2.5 on some boards, while WynnBET is dealing Browns -1.5 as of this Friday update. The total opened 52.5.

Giants at Saints (-7, 42)

New Orleans’ impressive showing in a 28-13 win in New England helped push this line from 6.5 in advanced wagering to -8, but that number was too big for the market’s tastes. So too was the earlier total of 43.5.

Titans (-6.5, 44.5) at Jets

The Titans are expected to be without starting wide receivers A.J. Brown and Julio Jones, and the spread has shrunk from 7.5. Some books, including FanDuel, are dealing -6. The total is also on its way down from as high as 47 in earlier wagering.

Chiefs (-7, 54.5) at Eagles

Kansas City opened -5.5 but reopened -7.5 after Philadelphia’s poor performance as 3-point dogs in Dallas on Monday night. While the hook has enticed dog bettors, Chiefs -6.5 is the most popular pick this week in our Bookies Battle contest.

Panthers at Cowboys (-4.5, 51.5)

Christian McCaffrey is among the few running backs whose absence impacts a betting line, and we’ve seen this number drift since 3.5 was hung last week. There’s been a point of resistance, though, as this week’s opening number of Dallas -5 didn’t last long against the unbeaten Panthers. Meanwhile, there’s been a move toward the OVER, as the total opened 50.

Cardinals at Rams (-4, 54.5)

Early interest has been on the dog, as the line has been bet down from 6. The total has been adjusted upward from 53.5 ahead of this battle of unbeatens.

49ers at Seahawks (-3 even, 52)

This number ranged from 2.5 to 3.5 in advanced wagering, as these divisional foes look to shake off Week 3 losses.

Ravens (-1, 44.5) at Broncos

The favorite has flipped twice here — Ravens -2.5 was hung on look-ahead oddsboards last week, while Sunday night’s opening price of Denver -2.5 drew interest in the underdog.

Steelers at Packers (-6.5, 45.5)

The Steelers are getting healthier, and dog and UNDER money has prompted moves from Green Bay -7 and 47.

Bucs (-7, 49) at Patriots

DraftKings’ look-ahead number was Bucs -3 (-120); if you got down on Tampa at that price, well done. The Sunday night opening line was Tampa -6, which looks pretty good now, too. There’s been some erosion in the betting market’s confidence in New England after rookie QB Mac Jones’ three-interception game against the Saints.

Raiders at Chargers (-3/-120, 51.5)

A small early market lean toward Los Angeles in this AFC West battle, the line moving from -3 in advanced wagering to -3 (-120).

Check out updated Super Bowl odds 2022.

About the Author
Marcus DiNitto

Marcus DiNitto

Sr. News Editor
Marcus DiNitto is Senior News Editor for Gaming Today. He has been managing editor at national sports websites SportsBusiness Daily, Sporting News, and The Linemakers, as well as with licensed sportsbook operator USA Sports Gaming. Marcus graduated from the University of Wisconsin-Madison and earned his MBA from the University of North Carolina-Charlotte.

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