NFL Week 4 Odds: Brady Vs. Belichick, NFC West Showdowns, And Largest Line Of Season Highlight Betting Slate

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Week 4 of the 2021 NFL season kicked off with the Bengals beating the Jaguars 24-21 on a field goal in the closing seconds Thursday night, but Jacksonville comfortably covering the spread as a 7.5-point underdog.

In Sunday action, while Buccaneers vs. Patriots is getting a lot of the buzz, we also have our eyes on two games pitting NFC West rivals against each other, a rematch of Super Bowl XLV, and the Bills laying the largest point spread of the season so far.

Monday night features a key showdown in the AFC West.

Live Week 4 Sportsbook Odds

Bet TypeSpreads
Open
Thu (9/28) @ 8:15pm ET DET Lions -120 -115 -125 -125 -122 -123 -120
GB Packers +100 -105 +105 +105 +108 +106 +100
Sun (10/1) @ 9:30am ET ATL Falcons +135 +136 +130 +143 +150 +138 +145
JAX Jaguars -161 -161 -154 -169 -175 -164 -175
Sun (10/1) @ 1:00pm ET MIA Dolphins +120 +130 +130 +130 +125 +120 +130
BUF Bills -145 -154 -161 -154 -143 -143 -161
Sun (10/1) @ 1:00pm ET BAL Ravens +105 +124 +120 +122 +125 +120 +115
CLE Browns -125 -147 -145 -145 -141 -143 -141
Sun (10/1) @ 1:01pm ET MIN Vikings -161 -179 -189 -196 -182 -179 -179
CAR Panthers +135 +150 +155 +162 +160 +150 +150
Sun (10/1) @ 1:01pm ET DEN Broncos -154 -161 -164 -169 -161 -167 -175
CHI Bears +130 +136 +140 +143 +140 +140 +145
Sun (10/1) @ 1:01pm ET PIT Steelers -164 -161 -164 -164 -156 -164 -149
HOU Texans +140 +136 +140 +140 +138 +138 +125
Sun (10/1) @ 1:01pm ET LA Rams -110 +102 +100 +100 +100 +108 +105
IND Colts -110 -122 -120 -120 -114 -127 -125
Sun (10/1) @ 1:01pm ET TB Buccaneers +130 +136 +145 +140 +145 +144 +145
NO Saints -154 -161 -175 -164 -167 -172 -175
Sun (10/1) @ 1:01pm ET WAS Commanders +240 +300 +300 +300 +310 +310 +300
PHI Eagles -303 -385 -400 -385 -370 -385 -370
Sun (10/1) @ 1:01pm ET CIN Bengals +105 -135 -135 -135 -135 -135 -145
TEN Titans -125 +114 +115 +115 +118 +116 +120
Sun (10/1) @ 4:06pm ET LV Raiders +170 +195 +200 +210 +205 +205 +200
LA Chargers -208 -238 -250 -263 -263 -250 -278
Sun (10/1) @ 4:25pm ET NE Patriots +240 +230 +240 +240 +245 +260 +240
DAL Cowboys -303 -294 -303 -303 -286 -323 -303
Sun (10/1) @ 4:25pm ET ARI Cardinals +550 +600 +600 +600 +550 +610 +600
SF 49ers -833 -909 -909 -909 -833 -909 -909
Sun (10/1) @ 8:20pm ET KC Chiefs -455 -500 -455 -455 -435 -500 -417
NY Jets +340 +380 +350 +345 +360 +385 +330
Mon (10/2) @ 8:15pm ET SEA Seahawks -125 +102 +100 +110 +105 +102 +105
NY Giants +105 -122 -120 -130 -120 -120 -125
Thu (9/28) @ 8:15pm ET DET Lions -1.5 -110 -1.0 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.0 -110
GB Packers +1.5 -110 +1.0 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.0 -110
Sun (10/1) @ 9:30am ET ATL Falcons +3.0 -110 +3.0 -105 +3.0 -110 +3.0 +110 +3.5 -114 +3.0 -105 +3.0 -105
JAX Jaguars -3.0 -110 -3.0 -115 -3.0 -110 -3.0 -130 -3.5 -108 -3.0 -115 -3.0 -115
Sun (10/1) @ 1:00pm ET MIA Dolphins +2.5 -110 +3.0 -110 +3.0 -110 +2.5 +100 +3.0 -112 +3.0 -120 +3.0 -110
BUF Bills -2.5 -110 -3.0 -110 -3.0 -110 -2.5 -120 -3.0 -109 -3.0 -102 -3.0 -110
Sun (10/1) @ 1:00pm ET BAL Ravens +2.5 -115 +2.5 -105 +2.5 -105 +2.5 -105 +2.5 -106 +2.5 -110 +2.5 -110
CLE Browns -2.5 -105 -2.5 -115 -2.5 -115 -2.5 -115 -2.5 -115 -2.5 -110 -2.5 -110
Sun (10/1) @ 1:01pm ET MIN Vikings -3.0 -110 -3.5 -112 -3.5 -110 -3.5 -110 -3.5 -110 -3.5 -114 -3.5 -110
CAR Panthers +3.0 -110 +3.5 -108 +3.5 -110 +3.5 -110 +3.5 -110 +3.5 -106 +3.5 -110
Sun (10/1) @ 1:01pm ET DEN Broncos -3.0 -110 -3.0 -118 -3.5 -105 -3.5 -105 -3.5 -108 -3.5 -104 -3.5 -105
CHI Bears +3.0 -110 +3.0 -102 +3.5 -115 +3.5 -115 +3.5 -114 +3.5 -118 +3.5 -115
Sun (10/1) @ 1:01pm ET PIT Steelers -3.5 -105 -3.0 -112 -3.0 -115 -3.0 -110 -3.0 -112 -3.0 -118 -3.0 -110
HOU Texans +3.5 -115 +3.0 -108 +3.0 -105 +3.0 -110 +3.0 -109 +3.0 -104 +3.0 -110
Sun (10/1) @ 1:01pm ET LA Rams +1.0 -115 +1.5 -110 +1.0 -110 +1.5 -110 +1.0 -109 +1.5 -105 +1.5 -110
IND Colts -1.0 -105 -1.5 -110 -1.0 -110 -1.5 -110 -1.0 -112 -1.5 -115 -1.5 -110
Sun (10/1) @ 1:01pm ET TB Buccaneers +3.0 -110 +3.0 -105 +3.5 -115 +3.0 -105 +3.5 -118 +3.0 -102 +3.0 -105
NO Saints -3.0 -110 -3.0 -115 -3.5 -105 -3.0 -115 -3.5 -105 -3.0 -120 -3.0 -115
Sun (10/1) @ 1:01pm ET WAS Commanders +7.0 -110 +8.0 -112 +8.5 -110 +8.0 -110 +8.0 -110 +8.5 -114 +8.0 -110
PHI Eagles -7.0 -110 -8.0 -108 -8.5 -110 -8.0 -110 -8.0 -110 -8.5 -106 -8.0 -110
Sun (10/1) @ 1:01pm ET CIN Bengals +1.5 -110 -2.5 -112 -2.5 -110 -2.5 -110 -2.5 -112 -2.5 -110 -2.5 -110
TEN Titans -1.5 -110 +2.5 -108 +2.5 -110 +2.5 -110 +2.5 -109 +2.5 -110 +2.5 -110
Sun (10/1) @ 4:06pm ET LV Raiders +4.5 -110 +5.5 -108 +5.5 -110 +5.5 -110 +6.0 -115 +6.0 -115 +6.0 -110
LA Chargers -4.5 -110 -5.5 -112 -5.5 -110 -5.5 -110 -6.0 -106 -6.0 -105 -6.0 -110
Sun (10/1) @ 4:25pm ET NE Patriots +7.0 -110 +7.0 -115 +7.0 -115 +7.0 -120 +6.5 -106 +6.5 -102 +7.0 -110
DAL Cowboys -7.0 -110 -7.0 -105 -7.0 -105 -7.0 +100 -6.5 -115 -6.5 -120 -7.0 -110
Sun (10/1) @ 4:25pm ET ARI Cardinals +14.0 -110 +14.0 -112 +14.0 -110 +14.0 -110 +14.0 -110 +14.0 -110 +14.0 -110
SF 49ers -14.0 -110 -14.0 -108 -14.0 -110 -14.0 -110 -14.0 -110 -14.0 -110 -14.0 -110
Sun (10/1) @ 8:20pm ET KC Chiefs -9.0 -110 -9.5 -115 -9.5 -110 -9.5 -110 -9.5 -112 -9.5 -115 -10.0 -110
NY Jets +9.0 -110 +9.5 -105 +9.5 -110 +9.5 -110 +9.5 -109 +9.5 -105 +10.0 -110
Mon (10/2) @ 8:15pm ET SEA Seahawks -1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110 +1.5 -110
NY Giants +1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110 -1.5 -110
Thu (9/28) @ 8:15pm ET DET Lions o44.5 -110 o46 -108 o45.5 -110 o46 -110 o46.0 -112 o45.5 -115 o46 -110
GB Packers u44.5 -110 u46 -112 u45.5 -110 u46 -110 u46.0 -109 u45.5 -105 u46 -110
Sun (10/1) @ 9:30am ET ATL Falcons o43.5 -110 o43 -110 o43.5 -110 o43.5 -110 o43.5 -110 o43.5 -110 o43.5 -110
JAX Jaguars u43.5 -110 u43 -110 u43.5 -110 u43.5 -110 u43.5 -110 u43.5 -110 u43.5 -110
Sun (10/1) @ 1:00pm ET MIA Dolphins u53.5 -110 u53.5 -110 u53.5 -110 u53.5 -110 u53.5 -108 u53.5 -115 u53.5 -110
BUF Bills o53.5 -110 o53.5 -110 o53.5 -110 o53.5 -110 o53.5 -114 o53.5 -105 o53.5 -110
Sun (10/1) @ 1:00pm ET BAL Ravens o42.5 -105 o41 -112 o41 -110 o41 -110 o41.0 -114 o40.5 -115 o41 -110
CLE Browns u42.5 -115 u41 -108 u41 -110 u41 -110 u41.0 -108 u40.5 -105 u41 -110
Sun (10/1) @ 1:01pm ET MIN Vikings u44.5 -110 u45 -108 u45.5 -110 u45.5 -110 u45.5 -112 u45.5 -110 u45.5 -110
CAR Panthers o44.5 -110 o45 -112 o45.5 -110 o45.5 -110 o45.5 -109 o45.5 -110 o45.5 -110
Sun (10/1) @ 1:01pm ET DEN Broncos u45.5 -115 u46 -110 u46 -110 u46 -110 u46.0 -110 u46 -110 u46 -110
CHI Bears o45.5 -105 o46 -110 o46 -110 o46 -110 o46.0 -110 o46 -110 o46 -110
Sun (10/1) @ 1:01pm ET PIT Steelers u40.5 -105 u42 -110 u42 -110 u42 -110 u42.0 -112 u42.5 -110 u42 -110
HOU Texans o40.5 -115 o42 -110 o42 -110 o42 -110 o42.0 -109 o42.5 -110 o42 -110
Sun (10/1) @ 1:01pm ET LA Rams u45 -110 u47 -112 u46.5 -110 u46.5 -110 u46.5 -112 u45.5 -115 u46.5 -110
IND Colts o45 -110 o47 -108 o46.5 -110 o46.5 -110 o46.5 -109 o45.5 -105 o46.5 -110
Sun (10/1) @ 1:01pm ET TB Buccaneers u40.5 -110 u40.5 -112 u40.5 -110 u40.5 -110 u40.5 -108 u40.5 -105 u40.5 -110
NO Saints o40.5 -110 o40.5 -108 o40.5 -110 o40.5 -110 o40.5 -114 o40.5 -115 o40.5 -110
Sun (10/1) @ 1:01pm ET WAS Commanders u44.5 -110 u44.5 -112 u44.5 -110 u44.5 -110 u44.5 -109 u44.5 -106 u44.5 -110
PHI Eagles o44.5 -110 o44.5 -108 o44.5 -110 o44.5 -110 o44.5 -112 o44.5 -114 o44.5 -110
Sun (10/1) @ 1:01pm ET CIN Bengals o42.5 -110 o41.5 -110 o41 -110 o41 -110 o41.5 -110 o40.5 -115 o41 -110
TEN Titans u42.5 -110 u41.5 -110 u41 -110 u41 -110 u41.5 -110 u40.5 -105 u41 -110
Sun (10/1) @ 4:06pm ET LV Raiders o50.5 -110 o47.5 -112 o47.5 -110 o47.5 -110 o47.5 -109 o47.5 -115 o47.5 -110
LA Chargers u50.5 -110 u47.5 -108 u47.5 -110 u47.5 -110 u47.5 -112 u47.5 -105 u47.5 -110
Sun (10/1) @ 4:25pm ET NE Patriots u42 -110 u43.5 -110 u43 -110 u43 -110 u43.0 -109 u43.5 -110 u43 -110
DAL Cowboys o42 -110 o43.5 -110 o43 -110 o43 -110 o43.0 -112 o43.5 -110 o43 -110
Sun (10/1) @ 4:25pm ET ARI Cardinals o42 -110 o43.5 -112 o44 -110 o44 -110 o44.0 -110 o43.5 -112 o44 -110
SF 49ers u42 -110 u43.5 -108 u44 -110 u44 -110 u44.0 -110 u43.5 -108 u44 -110
Sun (10/1) @ 8:20pm ET KC Chiefs o42.5 -110 o42.5 -110 o42.5 -110 o42.5 -110 o42.0 -110 o42.5 -110 o41.5 -110
NY Jets u42.5 -110 u42.5 -110 u42.5 -110 u42.5 -110 u42.0 -110 u42.5 -110 u41.5 -110
Mon (10/2) @ 8:15pm ET SEA Seahawks u45 -110 u47 -112 u47 -110 u47 -110 u46.5 -108 u46.5 -105 u46.5 -110
NY Giants o45 -110 o47 -108 o47 -110 o47 -110 o46.5 -114 o46.5 -115 o46.5 -110

NFL Week 4 Lines & Early Moves

Here are consensus point spreads and totals for Week 4, updated Friday afternoon.

Jaguars at Bengals (-7.5, 45.5)

DraftKings‘ original look-ahead line of Cincinnati -4.5 proved far too cheap, as the number was bet to -6 last week and reposted -7.5 Sunday night.

Washington (-1.5, 47.5) at Falcons

The line here has flipped since Atlanta -1 was the most common number in early wagering, while the total was bet down from 48.5

Texans at Bills (-17.5, 47)

A Josh Allen-led 22-point blowout over Washington, combined with an 0-3 Texans team that will again trot out third-string QB Davis Mills, gives us the largest point spread of the season so far. The line has ranged from 16.5 to 18 in early wagering, and the total has dipped from 48.

Lions at Bears (-3 even, 41.5)

Underdog bettors grabbed the opening number of Lions +3.5, and the total plummeted from 44. Chicago coach Matt Nagy says he’ll make a game-time decision on the team’s starter at QB.

Colts at Dolphins (-2, 42.5)

While early sentiment on the dog, at Indy +2.5 and +2, moved the line to 1.5, it has since moved back toward Miami, with a few shops dealing 2.5. Here’s another game with a downward-trending total.

Browns (-2, 51.5) at Vikings

We’re seeing Vikings +2.5 on some boards, while WynnBET is dealing Browns -1.5 as of this Friday update. The total opened 52.5.

Giants at Saints (-7, 42)

New Orleans’ impressive showing in a 28-13 win in New England helped push this line from 6.5 in advanced wagering to -8, but that number was too big for the market’s tastes. So too was the earlier total of 43.5.

Titans (-6.5, 44.5) at Jets

The Titans are expected to be without starting wide receivers A.J. Brown and Julio Jones, and the spread has shrunk from 7.5. Some books, including FanDuel, are dealing -6. The total is also on its way down from as high as 47 in earlier wagering.

Chiefs (-7, 54.5) at Eagles

Kansas City opened -5.5 but reopened -7.5 after Philadelphia’s poor performance as 3-point dogs in Dallas on Monday night. While the hook has enticed dog bettors, Chiefs -6.5 is the most popular pick this week in our Bookies Battle contest.

Panthers at Cowboys (-4.5, 51.5)

Christian McCaffrey is among the few running backs whose absence impacts a betting line, and we’ve seen this number drift since 3.5 was hung last week. There’s been a point of resistance, though, as this week’s opening number of Dallas -5 didn’t last long against the unbeaten Panthers. Meanwhile, there’s been a move toward the OVER, as the total opened 50.

Cardinals at Rams (-4, 54.5)

Early interest has been on the dog, as the line has been bet down from 6. The total has been adjusted upward from 53.5 ahead of this battle of unbeatens.

49ers at Seahawks (-3 even, 52)

This number ranged from 2.5 to 3.5 in advanced wagering, as these divisional foes look to shake off Week 3 losses.

Ravens (-1, 44.5) at Broncos

The favorite has flipped twice here — Ravens -2.5 was hung on look-ahead oddsboards last week, while Sunday night’s opening price of Denver -2.5 drew interest in the underdog.

Steelers at Packers (-6.5, 45.5)

The Steelers are getting healthier, and dog and UNDER money has prompted moves from Green Bay -7 and 47.

Bucs (-7, 49) at Patriots

DraftKings’ look-ahead number was Bucs -3 (-120); if you got down on Tampa at that price, well done. The Sunday night opening line was Tampa -6, which looks pretty good now, too. There’s been some erosion in the betting market’s confidence in New England after rookie QB Mac Jones’ three-interception game against the Saints.

Raiders at Chargers (-3/-120, 51.5)

A small early market lean toward Los Angeles in this AFC West battle, the line moving from -3 in advanced wagering to -3 (-120).

Check out updated Super Bowl odds 2022.

About the Author
Marcus DiNitto

Marcus DiNitto

Managing Editor, News
Marcus DiNitto was news managing editor of Gaming Today. In past roles, he has been managing editor at national sports websites SportsBusiness Daily, Sporting News, and The Linemakers, as well as with licensed sportsbook operator USA Sports Gaming. Marcus graduated from the University of Wisconsin-Madison, earned his MBA from the University of North Carolina-Charlotte, and studied sports and entertainment marketing at New York University.

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