NFL Week 5 Odds: Bills Hold Firm as Two-TD Favorite, Total Climbs for Seahawks-Saints is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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We’re here to update NFL Week 5 betting odds and identify line movements ahead of another full weekend of football before byes begin next week.

The Buffalo Bills (-14) opened as the biggest betting favorite on the slate against the Pittsburgh Steelers, and the line has held steady at DraftKings as of Friday.

Other games of interest include an AFC North showdown between the Cincinnati Bengals and Baltimore Ravens on Sunday Night Football and Cowboys-Rams in the NFC.

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NFL Week 5 Lines: Updated Point Spreads, Totals

Here are live odds from legal US sportsbooks on the Week 5 slate.

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Here’s a game-by-game look at NFL Week 5 lines for betting at DraftKings as of Friday, Oct. 7.

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Bengals at Ravens (-3.5, 47.5)

This line ticked up from an opener of Ravens -3. The total has been bet down from 48.5.

The Ravens will try to bounce back from their 23-20 loss to Buffalo. Cincinnati will have the luxury of 10 days to prepare for Lamar Jackson and company after its 27-15 win over Miami on TNF.

The Bengals easily won and covered both games against the Ravens last season, scoring 41 points in both contests.

Lamar Jackson and the Ravens are short favorites vs. the Bengals, according to NFL Week 5 odds (AP Photo/Michael Dwyer)

Cowboys at Rams (-5.5, 43)

Some support for Big D here after the Rams opened at -6. Cooper Rush will be back under center for Dallas. Starting QB Dak Prescott (thumb) remains at least a week away from returning.

Rush is 4-0 overall and ATS in four career starts. He is also turnover free in three games as a starter this year.

The Rams have yet to cover a game at home this season. LA is 0-2 with a big loss to Buffalo in the season opener and a narrow win against Atlanta.

Eagles (-5.5, 48) at Cardinals

Philadelphia, which opened at -6, stands as the last remaining unbeaten team this year after Sunday’s 29-21 win over Jacksonville.

DraftKings was dealing the Eagles at +2500 to go undefeated this week.

Raiders at Chiefs (-7, 51)

KC opened at -6.5 after last week’s 41-31 beatdown of the Bucs at Tampa Bay.

Decent Monday Night Football matchup here if the Raiders decide to show up against Patrick Mahomes & Company at Arrowhead. Las Vegas started 0-3 overall and ATS before beating the Broncos in Week 4.

The Raiders lost both games to KC last year by a combined score of 89-23.

Giants at Packers (-7.5, 41)

The status of starting QB Daniel Jones (ankle) and backup Tyrod Taylor (concussion) are both uncertain heading into New York’s overseas game against the Packers. But both QBs made the trip to London, and Jones is reportedly making decent progress.
The Packers will again be another Survivor Pool favorite after they barely escaped a depleted New England team 27-24 in Week 4.

Steelers at Bills (-14, 46)

The biggest spread on the Week 5 board didn’t budge at DraftKings. Kenny Pickett replaced Mitch Trubisky at QB, but the Steelers still found a way to lose to the Jets. Pickett tossed three picks in that game, and Buffalo’s defense could make life miserable for the rookie in Week 5.
Buffalo was 3-1-2 ATS last season as a favorite of two TDs or more.

Texans at Jaguars (-7, 43.5)

Jacksonville is a prime candidate to bounce off last week’s 29-21 loss to Philadelphia. The Texans remain winless at 0-3-1 after last week’s loss to the Chargers. The Texans failed to cover ATS for the first time this season in the 34-24 loss.

Seahawks at Saints (-5.5, 46)

There was significant movement here on the total, which opened 42.5 at DraftKings. Saints backup QB Andy Dalton looked good filling in for Jameis Winston during last week’s heartbreaking loss to Minnesota in London.

Winston (back/ankle/hip) did not practice Wednesday or Thursday. He’s among a number of key players uncertain to start against the Seahawks along with RB Alvin Kamara (rib) and WR Michael Thomas (toe).

Meanwhile, Seattle’s Geno Smith looked unstoppable in a 48-45 win at Detroit. He was named NFC Offensive Player of the Week for his efforts. Good luck trying to figure this league out on a weekly basis.

Bears at Vikings (-7.5, 44)

Slight move here toward the home team after Minnesota opened at -7. Chicago’s offense has been putrid under QB Justin Fields. The Bears are last in the league when it comes passing offense (97.5 yards per game) and second to last in points per game (16).

Dolphins (-3, 46) at Jets

Miami was -6 on the look-ahead line in this one at DraftKings before QB Tua Tagovailoa’s scary concussion on TNF at Cincinnati. The Dolphins announced he won’t play against the Jets, paving the way for veteran backup Teddy Bridgewater to start.

Miami opened at -3, and that number remained at DraftKings as of Friday. The Dolphins were juiced to -115 on the current spread.

Lions at Patriots (-3.5, 45.5)

New England money has upped this line from an opener of Pats -2.5. Who starts at QB for the home team? Mac Jones (ankle) was reportedly limping at practice yesterday, and backup Brian Hoyer (concussion) was relegated to IR. It will likely be rookie Bailey Zappe under center against the Lions.

It might not matter. Detroit’s defense is becoming a real concern. The Lions are giving up a league-high 35.3 points per game.

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The Rest of NFL Week 5 Lines

Chargers (-2, 47.5) at Browns

Los Angeles opened -3.

49ers (-6.5, 39) at Panthers

San Francisco opened -4.

Falcons at Buccaneers (-10, 46)

Tampa Bay opened -9.

Titans (-1.5, 43) at Commanders

Tennessee opened -2.5.

About the Author
Kris Johnson

Kris Johnson

Senior Writer
Kris Johnson is a senior writer at Gaming Today with more than 15 years of experience as a sports journalist. Johnson's work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and other publications. He also authored a sports betting novel titled The Endgame.

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