We’re here to update NFL Week 5 betting odds and identify line movements ahead of another full weekend of football before byes begin next week.
The Buffalo Bills (-14) opened as the biggest betting favorite on the slate against the Pittsburgh Steelers, and the line has held steady at DraftKings as of Friday.
Other games of interest include an AFC North showdown between the Cincinnati Bengals and Baltimore Ravens on Sunday Night Football and Cowboys-Rams in the NFC.
NFL Week 5 Lines: Updated Point Spreads, Totals
Here are live odds from legal US sportsbooks on the Week 5 slate.
Here’s a game-by-game look at NFL Week 5 lines for betting at DraftKings as of Friday, Oct. 7.
Bengals at Ravens (-3.5, 47.5)
This line ticked up from an opener of Ravens -3. The total has been bet down from 48.5.
The Ravens will try to bounce back from their 23-20 loss to Buffalo. Cincinnati will have the luxury of 10 days to prepare for Lamar Jackson and company after its 27-15 win over Miami on TNF.
The Bengals easily won and covered both games against the Ravens last season, scoring 41 points in both contests.
Cowboys at Rams (-5.5, 43)
Some support for Big D here after the Rams opened at -6. Cooper Rush will be back under center for Dallas. Starting QB Dak Prescott (thumb) remains at least a week away from returning.
Rush is 4-0 overall and ATS in four career starts. He is also turnover free in three games as a starter this year.
The Rams have yet to cover a game at home this season. LA is 0-2 with a big loss to Buffalo in the season opener and a narrow win against Atlanta.
Eagles (-5.5, 48) at Cardinals
Philadelphia, which opened at -6, stands as the last remaining unbeaten team this year after Sunday’s 29-21 win over Jacksonville.
DraftKings was dealing the Eagles at +2500 to go undefeated this week.
Raiders at Chiefs (-7, 51)
KC opened at -6.5 after last week’s 41-31 beatdown of the Bucs at Tampa Bay.
Decent Monday Night Football matchup here if the Raiders decide to show up against Patrick Mahomes & Company at Arrowhead. Las Vegas started 0-3 overall and ATS before beating the Broncos in Week 4.
The Raiders lost both games to KC last year by a combined score of 89-23.
Giants at Packers (-7.5, 41)
Steelers at Bills (-14, 46)
Texans at Jaguars (-7, 43.5)
Seahawks at Saints (-5.5, 46)
There was significant movement here on the total, which opened 42.5 at DraftKings. Saints backup QB Andy Dalton looked good filling in for Jameis Winston during last week’s heartbreaking loss to Minnesota in London.
Winston (back/ankle/hip) did not practice Wednesday or Thursday. He’s among a number of key players uncertain to start against the Seahawks along with RB Alvin Kamara (rib) and WR Michael Thomas (toe).
Meanwhile, Seattle’s Geno Smith looked unstoppable in a 48-45 win at Detroit. He was named NFC Offensive Player of the Week for his efforts. Good luck trying to figure this league out on a weekly basis.
Bears at Vikings (-7.5, 44)
Slight move here toward the home team after Minnesota opened at -7. Chicago’s offense has been putrid under QB Justin Fields. The Bears are last in the league when it comes passing offense (97.5 yards per game) and second to last in points per game (16).
Dolphins (-3, 46) at Jets
Miami was -6 on the look-ahead line in this one at DraftKings before QB Tua Tagovailoa’s scary concussion on TNF at Cincinnati. The Dolphins announced he won’t play against the Jets, paving the way for veteran backup Teddy Bridgewater to start.
Miami opened at -3, and that number remained at DraftKings as of Friday. The Dolphins were juiced to -115 on the current spread.
Lions at Patriots (-3.5, 45.5)
New England money has upped this line from an opener of Pats -2.5. Who starts at QB for the home team? Mac Jones (ankle) was reportedly limping at practice yesterday, and backup Brian Hoyer (concussion) was relegated to IR. It will likely be rookie Bailey Zappe under center against the Lions.
It might not matter. Detroit’s defense is becoming a real concern. The Lions are giving up a league-high 35.3 points per game.
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The Rest of NFL Week 5 Lines
Chargers (-2, 47.5) at Browns
Los Angeles opened -3.
49ers (-6.5, 39) at Panthers
San Francisco opened -4.
Falcons at Buccaneers (-10, 46)
Tampa Bay opened -9.
Titans (-1.5, 43) at Commanders
Tennessee opened -2.5.