NFL Week 5 Odds: Bills Hold Firm as Two-TD Favorite, Total Climbs for Seahawks-Saints

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We’re here to update NFL Week 5 betting odds and identify line movements ahead of another full weekend of football before byes begin next week.

The Buffalo Bills (-14) opened as the biggest betting favorite on the slate against the Pittsburgh Steelers, and the line has held steady at DraftKings as of Friday.

Other games of interest include an AFC North showdown between the Cincinnati Bengals and Baltimore Ravens on Sunday Night Football and Cowboys-Rams in the NFC.

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NFL Week 5 Lines: Updated Point Spreads, Totals

Here are live odds from legal US sportsbooks on the Week 5 slate.

Bet TypeSpreads
Open
Thu (10/6) @ 8:15pm ET IND Colts +140 +110 +140 +130 +104 +100
DEN Broncos -164 -141 -189 -161 -132 -120
Sun (10/9) @ 9:32am ET NY Giants +275 0 -10000 -455 0 -303
GB Packers -345 +2500 +2000 +340 +5000 +240
Sun (10/9) @ 1:00pm ET PIT Steelers +600 +1700 +3300 +1600 +630 +10000 +10000
BUF Bills -909 -10000 -10000 -5000 -833 0 0
Sun (10/9) @ 1:00pm ET CHI Bears +260 +1000 +165 +850 +305 +10000 +15000
MIN Vikings -345 -2000 -227 -1667 -370 0 0
Sun (10/9) @ 1:00pm ET SEA Seahawks +180 +2500 +3300 +900 +193 +3000 +1700
NO Saints -227 0 -10000 -1667 -227 0 -5000
Sun (10/9) @ 1:01pm ET LA Chargers -161 -154 -189 +130 0 -105
CLE Browns +135 +125 +145 -161 +10000 -110
Sun (10/9) @ 1:02pm ET DET Lions +120 +1600 +2500 +1400 +10000 +17500
NE Patriots -145 -10000 -10000 -5000 0 0
Sun (10/9) @ 1:02pm ET MIA Dolphins -149 +800 +180 +575 +10000 0
NY Jets +125 -1429 -250 -909 0 0
Sun (10/9) @ 1:03pm ET TEN Titans -149 +270 -370 -5000 -154 0
WAS Commanders +125 -345 +270 +2000 +120 0
Sun (10/9) @ 1:03pm ET HOU Texans +260 -10000 -141 -833 0 0
JAX Jaguars -345 +2000 +105 +525 +2000 +4500
Sun (10/9) @ 1:03pm ET ATL Falcons +300 +1400 +3300 +1600 +2200 +6000
TB Buccaneers -370 -5000 -10000 -5000 0 0
Sun (10/9) @ 4:05pm ET SF 49ers -227 -3333 -10000 -2000 -244 0 0
CAR Panthers +185 +1200 +3300 +1000 +210 +10000 +4500
Sun (10/9) @ 4:25pm ET PHI Eagles -227 -208 -10000 -179 -233 -213 -238
ARI Cardinals +185 +170 +3300 +150 +195 +164 +190
Sun (10/9) @ 4:25pm ET DAL Cowboys +200 -10000 -10000 -2500 +193 -10000 0
LA Rams -250 +1600 +1500 +1100 -227 +1700 0
Sun (10/9) @ 8:22pm ET CIN Bengals +155 +1000 +550 +400 +140 +800 +600
BAL Ravens -185 -2000 -833 -556 -159 -1667 -1250
Mon (10/10) @ 8:15pm ET LV Raiders +260 +245 +110 +185 +10000 +190
KC Chiefs -345 -313 -145 -233 0 -238
Thu (10/6) @ 8:15pm ET IND Colts +3.0 -110 +3.0 +100 +1.5 -278 +2.5 +225 -1.5 +114 +3.5 -169
DEN Broncos -3.0 -110 -3.0 -130 -1.5 +200 -2.5 -278 +1.5 -147 -3.5 +140
Sun (10/9) @ 9:32am ET NY Giants +7.5 -115 -3.5 -105 -1.5 -10000 -4.5 -400 -4.5 0 -4.0 -108
GB Packers -7.5 -105 +3.5 -125 +1.5 +2000 +4.5 +300 +4.5 +6000 +4.0 -108
Sun (10/9) @ 1:00pm ET PIT Steelers +13.5 -105 +34.5 +120 +30.5 -110 +35.0 +165 +14.0 -110 +29.5 +7000 +29.0 -110
BUF Bills -13.5 -115 -34.5 -149 -30.5 -115 -35.0 -200 -14.0 -110 -29.5 0 -29.0 -105
Sun (10/9) @ 1:00pm ET CHI Bears +7.0 -110 +2.5 -135 +2.5 -161 +1.5 +120 +8.5 -112 +7.5 0 +7.0 -169
MIN Vikings -7.0 -110 -2.5 +105 -2.5 +125 -1.5 -149 -8.5 -109 -7.5 +6000 -7.0 +140
Sun (10/9) @ 1:00pm ET SEA Seahawks +4.5 -110 +5.5 +100 +5.5 -115 +600.0 0 +5.0 -109 +7.5 -714 +7.0 -303
NO Saints -4.5 -110 -5.5 -130 -5.5 -110 -600.0 -556 -5.0 -112 -7.5 +430 -7.0 +240
Sun (10/9) @ 1:01pm ET LA Chargers -3.0 -105 -1.5 -130 -2.5 -115 -1.5 -141 -8.5 +7500 +1.0 0
CLE Browns +3.0 -115 +1.5 +100 +2.5 -115 +1.5 +110 +8.5 -204 -1.0 0
Sun (10/9) @ 1:02pm ET DET Lions +3.0 -115 +26.0 -120 +23.5 -115 +29.0 +115 +23.5 +3500 +29.0 +200
NE Patriots -3.0 -105 -26.0 -110 -23.5 -110 -29.0 -145 -23.5 0 -29.0 -250
Sun (10/9) @ 1:02pm ET MIA Dolphins -3.0 -105 +17.0 -110 +2.5 -105 +22.5 +110 +23.5 +2200 +16.5 0
NY Jets +3.0 -115 -17.0 -120 -2.5 -125 -22.5 -141 -23.5 0 -16.5 0
Sun (10/9) @ 1:03pm ET TEN Titans -2.5 -115 -4.0 -130 -4.5 -115 -4.0 -400 -3.5 -152 -4.0 -141
WAS Commanders +2.5 -105 +4.0 +100 +4.5 -110 +4.0 +300 +3.5 +116 +4.0 +120
Sun (10/9) @ 1:03pm ET HOU Texans +7.0 -110 +2.5 +120 -1.5 -125 -7.0 +100 -12.5 +6000 -6.5 -200
JAX Jaguars -7.0 -110 -2.5 -149 +1.5 -105 +7.0 -130 +12.5 0 +6.5 +165
Sun (10/9) @ 1:03pm ET ATL Falcons +7.5 -110 +13.5 -110 +14.5 -141 +13.5 +100 +8.5 +175 +6.5 -200
TB Buccaneers -7.5 -110 -13.5 -120 -14.5 +105 -13.5 -130 -8.5 -233 -6.5 +165
Sun (10/9) @ 4:05pm ET SF 49ers -5.0 -110 -21.5 -714 -15.5 +140 -22.0 +155 -6.0 -109 -21.5 -10000 -21.5 -110
CAR Panthers +5.0 -110 +21.5 +490 +15.5 -185 +22.0 -189 +6.0 -112 +21.5 +1600 +21.5 -105
Sun (10/9) @ 4:25pm ET PHI Eagles -5.5 -105 -4.5 +110 -6.5 -115 -5.5 -135 -5.5 -110 -2.5 -196 -6.5 -108
ARI Cardinals +5.5 -115 +4.5 -141 +6.5 -110 +5.5 +105 +5.5 -110 +2.5 +148 +6.5 -108
Sun (10/9) @ 4:25pm ET DAL Cowboys +4.5 -110 -6.5 +110 -6.5 -115 -12.0 -500 +5.0 -109 -5.5 -110 -11.5 -145
LA Rams -4.5 -110 +6.5 -141 +6.5 -115 +12.0 +375 -5.0 -112 +5.5 -118 +11.5 +125
Sun (10/9) @ 8:22pm ET CIN Bengals +3.5 -110 +6.0 -105 +5.5 +100 +1.5 +210 +3.0 -105 +2.5 -233 +2.5 -120
BAL Ravens -3.5 -110 -6.0 -125 -5.5 -130 -1.5 -263 -3.0 -115 -2.5 +172 -2.5 +105
Mon (10/10) @ 8:15pm ET LV Raiders +7.5 -115 +5.0 -125 +1.5 -10000 +6.5 +115 +1.5 0 +6.5 +135
KC Chiefs -7.5 -105 -5.0 -105 -1.5 +3300 -6.5 -145 -1.5 +7500 -6.5 -161
Thu (10/6) @ 8:15pm ET IND Colts u43.5 -115 u21 -115 u25.5 -185 u26.5 +390 u21 -115
DEN Broncos o43.5 -105 o21 -115 o25.5 +140 o26.5 -625 o21 +100
Sun (10/9) @ 9:32am ET NY Giants u41.5 -105 u46 -105 u49.5 -10000 u49.5 0 u54 -108
GB Packers o41.5 -115 o46 -125 o49.5 +1600 o49.5 +3000 o54 -108
Sun (10/9) @ 1:00pm ET PIT Steelers u47.5 -110 u43.5 -115 u44.5 -120 u44.5 -110 u45.0 -114 u41.5 0 u47 +100
BUF Bills o47.5 -110 o43.5 -115 o44.5 +100 o44.5 -110 o45.0 -108 o41.5 +7000 o47 -115
Sun (10/9) @ 1:00pm ET CHI Bears o42.5 -115 o51.5 -105 o49.5 +110 o44 -110 o44.0 -112 o51.5 +6000 o51.5 +220
MIN Vikings u42.5 -105 u51.5 -125 u49.5 -135 u44 -110 u44.0 -109 u51.5 0 u51.5 -278
Sun (10/9) @ 1:00pm ET SEA Seahawks u43.5 -110 u62 -110 u56.5 -115 u45 -110 u46.0 -110 u71.5 -476 u62.5 +110
NO Saints o43.5 -110 o62 -120 o56.5 -105 o45 -110 o46.0 -110 o71.5 +320 o62.5 -130
Sun (10/9) @ 1:01pm ET LA Chargers u48.5 -105 u64.5 -115 u68.5 +100 u58.5 +165 u65.5 0
CLE Browns o48.5 -115 o64.5 -115 o68.5 -120 o58.5 +7500 o65.5 0
Sun (10/9) @ 1:02pm ET DET Lions o46.5 -110 o34.5 -120 o33.5 +140 o29.5 +1700 o34.5 -108
NE Patriots u46.5 -110 u34.5 -110 u33.5 -175 u29.5 0 u34.5 -108
Sun (10/9) @ 1:02pm ET MIA Dolphins o44.5 -110 o57.5 +185 o45.5 -135 o57.5 +7500 o63.5 0
NY Jets u44.5 -110 u57.5 -233 u45.5 +110 u57.5 0 u63.5 0
Sun (10/9) @ 1:03pm ET TEN Titans o42.5 -105 o45 -115 o50.5 -125 o38.5 +114 o44.5 -135
WAS Commanders u42.5 -115 u45 -115 u50.5 -105 u38.5 -147 u44.5 +115
Sun (10/9) @ 1:03pm ET HOU Texans o44.5 -105 o18.5 -125 o18.5 -154 o19.5 +4000 o20.5 +110
JAX Jaguars u44.5 -115 u18.5 -105 u18.5 +120 u19.5 0 u20.5 -130
Sun (10/9) @ 1:03pm ET ATL Falcons o48.5 -110 o35.5 +105 o36.5 +100 o39.5 +182 o37.5 +135
TB Buccaneers u48.5 -110 u35.5 -135 u36.5 -130 u39.5 -244 u37.5 -161
Sun (10/9) @ 4:05pm ET SF 49ers u39.5 -110 u49 -105 u49.5 -141 u40.0 -112 u52.5 -10000 u48.5 -110
CAR Panthers o39.5 -110 o49 -125 o49.5 +105 o40.0 -109 o52.5 +1600 o48.5 -105
Sun (10/9) @ 4:25pm ET PHI Eagles u49.5 -110 u40.5 +110 u37.5 -130 u48.5 -110 u48.5 -109 u42.5 +125 u37.5 -105
ARI Cardinals o49.5 -110 o40.5 -141 o37.5 +100 o48.5 -110 o48.5 -112 o42.5 -164 o37.5 -110
Sun (10/9) @ 4:25pm ET DAL Cowboys o45.5 -110 o38.5 -120 o35.5 -125 o42.0 -110 o38.5 -132 o33.5 +115
LA Rams u45.5 -110 u38.5 -110 u35.5 -105 u42.0 -110 u38.5 +102 u33.5 -135
Sun (10/9) @ 8:22pm ET CIN Bengals u48.5 -115 u36 -105 u36.5 -125 u47.5 -110 u36.5 -213 u33 +115
BAL Ravens o48.5 -105 o36 -125 o36.5 -105 o47.5 -110 o36.5 +162 o33 -135
Mon (10/10) @ 8:15pm ET LV Raiders u52.5 -110 u60.5 -120 u60.5 -120 u59.5 0 u58.5 -105
KC Chiefs o52.5 -110 o60.5 -110 o60.5 +100 o59.5 +2200 o58.5 -110

Here’s a game-by-game look at NFL Week 5 lines for betting at DraftKings as of Friday, Oct. 7.

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Bengals at Ravens (-3.5, 47.5)

This line ticked up from an opener of Ravens -3. The total has been bet down from 48.5.

The Ravens will try to bounce back from their 23-20 loss to Buffalo. Cincinnati will have the luxury of 10 days to prepare for Lamar Jackson and company after its 27-15 win over Miami on TNF.

The Bengals easily won and covered both games against the Ravens last season, scoring 41 points in both contests.

Lamar Jackson and the Ravens are short favorites vs. the Bengals, according to NFL Week 5 odds (AP Photo/Michael Dwyer)

Cowboys at Rams (-5.5, 43)

Some support for Big D here after the Rams opened at -6. Cooper Rush will be back under center for Dallas. Starting QB Dak Prescott (thumb) remains at least a week away from returning.

Rush is 4-0 overall and ATS in four career starts. He is also turnover free in three games as a starter this year.

The Rams have yet to cover a game at home this season. LA is 0-2 with a big loss to Buffalo in the season opener and a narrow win against Atlanta.

Eagles (-5.5, 48) at Cardinals

Philadelphia, which opened at -6, stands as the last remaining unbeaten team this year after Sunday’s 29-21 win over Jacksonville.

DraftKings was dealing the Eagles at +2500 to go undefeated this week.

Raiders at Chiefs (-7, 51)

KC opened at -6.5 after last week’s 41-31 beatdown of the Bucs at Tampa Bay.

Decent Monday Night Football matchup here if the Raiders decide to show up against Patrick Mahomes & Company at Arrowhead. Las Vegas started 0-3 overall and ATS before beating the Broncos in Week 4.

The Raiders lost both games to KC last year by a combined score of 89-23.

Giants at Packers (-7.5, 41)

The status of starting QB Daniel Jones (ankle) and backup Tyrod Taylor (concussion) are both uncertain heading into New York’s overseas game against the Packers. But both QBs made the trip to London, and Jones is reportedly making decent progress.
The Packers will again be another Survivor Pool favorite after they barely escaped a depleted New England team 27-24 in Week 4.

Steelers at Bills (-14, 46)

The biggest spread on the Week 5 board didn’t budge at DraftKings. Kenny Pickett replaced Mitch Trubisky at QB, but the Steelers still found a way to lose to the Jets. Pickett tossed three picks in that game, and Buffalo’s defense could make life miserable for the rookie in Week 5.
Buffalo was 3-1-2 ATS last season as a favorite of two TDs or more.

Texans at Jaguars (-7, 43.5)

Jacksonville is a prime candidate to bounce off last week’s 29-21 loss to Philadelphia. The Texans remain winless at 0-3-1 after last week’s loss to the Chargers. The Texans failed to cover ATS for the first time this season in the 34-24 loss.

Seahawks at Saints (-5.5, 46)

There was significant movement here on the total, which opened 42.5 at DraftKings. Saints backup QB Andy Dalton looked good filling in for Jameis Winston during last week’s heartbreaking loss to Minnesota in London.

Winston (back/ankle/hip) did not practice Wednesday or Thursday. He’s among a number of key players uncertain to start against the Seahawks along with RB Alvin Kamara (rib) and WR Michael Thomas (toe).

Meanwhile, Seattle’s Geno Smith looked unstoppable in a 48-45 win at Detroit. He was named NFC Offensive Player of the Week for his efforts. Good luck trying to figure this league out on a weekly basis.

Bears at Vikings (-7.5, 44)

Slight move here toward the home team after Minnesota opened at -7. Chicago’s offense has been putrid under QB Justin Fields. The Bears are last in the league when it comes passing offense (97.5 yards per game) and second to last in points per game (16).

Dolphins (-3, 46) at Jets

Miami was -6 on the look-ahead line in this one at DraftKings before QB Tua Tagovailoa’s scary concussion on TNF at Cincinnati. The Dolphins announced he won’t play against the Jets, paving the way for veteran backup Teddy Bridgewater to start.

Miami opened at -3, and that number remained at DraftKings as of Friday. The Dolphins were juiced to -115 on the current spread.

Lions at Patriots (-3.5, 45.5)

New England money has upped this line from an opener of Pats -2.5. Who starts at QB for the home team? Mac Jones (ankle) was reportedly limping at practice yesterday, and backup Brian Hoyer (concussion) was relegated to IR. It will likely be rookie Bailey Zappe under center against the Lions.

It might not matter. Detroit’s defense is becoming a real concern. The Lions are giving up a league-high 35.3 points per game.

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The Rest of NFL Week 5 Lines

Chargers (-2, 47.5) at Browns

Los Angeles opened -3.

49ers (-6.5, 39) at Panthers

San Francisco opened -4.

Falcons at Buccaneers (-10, 46)

Tampa Bay opened -9.

Titans (-1.5, 43) at Commanders

Tennessee opened -2.5.

About the Author
Kris Johnson

Kris Johnson

Writer & Contributor
Kris Johnson is a Senior Writer at Gaming Today with more than 15 years of experience as a sports journalist. Kris' work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and more. Kris also authored a sports betting novel entitled The Endgame.

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