NFL Week 5 Odds, Picks: 49ers Favored Against Cowboys on Sunday Night

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With the “first quarter” of the NFL season in the books, it’s time to turn our attention to an intriguing Week 5 slate. Jaguars vs. Bills in London on Sunday at 9:30 a.m. ET and Cowboys-49ers on Sunday Night Football are the marquee matchups, but Eagles-Rams at 4:05 p.m. ET is among the other games worth watching.

 

We recommend the best NFL betting sites in Gaming Today’s overview of the odds for the best games of Week 5. Let’s break down the best NFL Week 5 odds and analyze a few of the best matchups here.

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NFL Odds for Week 5 at BetMGM

View the table below to find NFL Week 5 odds available at BetMGM Sportsbook. You can sign up to BetMGM today and claim one of two offers. Get up to $1,500 in Bonus Bets (promo code: TODAY) if your first bet of equal value loses, or Bet $10 and Get $200 in Bonus Bets (promo code: GETTODAY).

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GameSpreadMoneylineOver/Under
Bears (0-4)
Commanders (2-2)
+6.5 (-105)
-6.5 (-115)
+240
-300
44.5 (-110)
Jaguars (2-2)
Bills (3-1)
+5.5 (-110)
-5.5 (-110)
+200
-250
49 (-110)
Texans (2-2)
Falcons (2-2)
+1 (-110)
-1 (-110)
-105
-115
41.5 (-110)
Panthers (0-4)
Lions (3-1)
+9 (-110)
-9 (-110)
+340
-450
45 (-110)
Titans (2-2)
Colts (2-2)
+1.5 (-110)
-1.5 (-110)
+100
-120
42.5 (-110)
Giants (1-3)
Dolphins (3-1)
+11 (-110)
-11 (-110)
+425
-600
49.5 (-110)
Saints (2-2)
Patriots (1-3)
+1.5 (-110)
-1.5 (-110)
+105
-125
40 (-110)
Ravens (3-1)
Steelers (2-2)
-4.5 (-110)
+4.5 (-110)
-225
+180
38.5 (-110)
Eagles (4-0)
Rams (2-2)
-4.5 (-110)
+4.5 (-110)
-210
+170
50 (-110)
Bengals (1-3)
Cardinals (1-3)
-3 (-110)
+3 (-110)
-165
+135
44.5 (-110)
Jets (1-3)
Broncos (1-3)
+1.5 (-110)
-1.5 (-110)
+105
-125
43.5 (-110)
Chiefs (3-1)
Vikings (1-3)
-5.5 (-110)
+5.5 (-110)
-225
+185
52.5 (-110)
Cowboys (3-1)
49ers (4-0)
+3.5 (-110)
-3.5 (-110)
+150
-185
45 (-110)
Packers (2-2)
Raiders (1-3)
-2.5 (-105)
+2.5 (-115)
-130
+110
44.5 (-110)

These odds are updated as of Tuesday, Oct. 3.

Week 5 NFL Betting Picks, Analysis

Chicago Bears (0-4) at Washington Commanders (2-2)

  • Time: Thursday, 8:15 p.m. ET
  • TV/Live Stream: Prime Video

Both the Bears and Commanders are coming off frustrating losses. The Bears lost to another struggling team, the Broncos, despite leading 28-7 in the third quarter, while Washington lost to division rival Philadelphia 34-31 in overtime. Bears QB Justin Fields had his best performance of the season against Denver, with 335 yards passing and four TDs, but had a costly fumble in the fourth quarter that directly led to a game-tying TD by the Broncos. If Fields — and it’s a big if — can continue to lean on WR D.J. Moore (8 catches, 131 yards, 1 TD against Denver) and keep the Chicago offense moving, the Bears should be able to at least keep this game close. Three of the Commanders’ first four games of the season have been decided by three points or less, making it tempting to take the Bears and the points.

Pick: Bears (+7 at time of publishing)

Jacksonville Jaguars (2-2) at Buffalo Bills (3-1) (London)

  • Time: Sunday, 9:30 a.m. ET
  • TV/Live Stream: NFL Network

The Bills are coming off one of the most impressive wins of the season — across the entire league — a 48-20 win over the previously undefeated Miami Dolphins. Buffalo QB Josh Allen had one of the best games of his career against the Dolphins. If he can play anywhere near that level, while avoiding careless mistakes, Buffalo is a legitimate threat in the AFC. Jacksonville is 2-2 following a 23-7 win over the Falcons in London. The Jags haven’t quite lived up to the offseason hype after winning a playoff game last year, but QB Trevor Lawrence and the offense were efficient against the Falcons in Week 3. Expect Lawrence and the Jaguars to get off to a strong start in front of their “home” fans in London, where they’re set to play for the 11th time.

Pick: Jaguars first half (+3.5 at time of publishing)

Baltimore Ravens (3-1) at Pittsburgh Steelers (2-2)

  • Time: Sunday 1:00 p.m. ET
  • TV/Live Stream: CBS

Lamar Jackson and the Ravens moved to 3-1 by controlling their Week 4 matchup against the Browns, while Pittsburgh was embarrassed in a 30-6 loss to Houston. The Steelers are in the mix in the AFC North thanks to their wins over Cleveland in Week 2 and Las Vegas in Week 3, but QB Kenny Pickett and the offense have been completely stifled in two of their first four games (they were also shut down by San Francisco in Week 1). The Steelers’ pass rush will create some problems for Ravens QB Lamar Jackson, especially in Pittsburgh, but it’s easy to see Baltimore not only winning but covering after its 28-3 win over a Cleveland team with one of the best defenses in the NFL.

Pick: Ravens (-4.5 at time of publishing)

Dallas Cowboys (3-1) at San Francisco 49ers (4-0)

  •  Time: Sunday, 8:20 p.m. ET
  • TV/Live Stream: NBC

The Week 5 edition of Sunday Night Football pits two of the most dominant teams in the league through the first month of the season. The 49ers have been dominant in three of their four wins this year (only the Rams, in Week 2, were competitive against them), while Dallas has piled up three wins by at least 20 points but also lost a head-scratcher against the Cardinals. This game will feel as much like a playoff battle as an early-October contest possibly can, with San Francisco QB Brock Purdy and RB Christian McCaffrey facing a tough test from LB Micah Parsons and the Cowboys’ talented D. On the other side of the ball, Nick Bosa and Co. are looking for another dominant performance after holding three of their first four opponents to 16 points or fewer. It’s easy to see both Purdy and Dak Prescott struggling against tough defenses, making the Under the best play.

Pick: Under (45 at time of publishing)

Green Bay Packers (2-2) at Las Vegas Raiders (1-3)

  • Time: Monday, 8:15 p.m. ET
  • TV/Live Stream: ABC, ESPN

Despite their stunning fourth-quarter comeback win against the Saints, QB Jordan Love and the Packers don’t have it all figured out yet, as we saw in their Week 4 loss to the Lions. Still, Green Bay looks like a solid team, and whether the Raiders start Aidan O’Connell or Jimmy Garoppolo at quarterback, the Packers feel like a safe bet considering Las Vegas is yet to score more than 18 points in a game through four weeks. Love’s first primetime game did not go according to plan against the Lions last week, but he’ll bounce back against the Raiders to get Green Bay to 3-2 on the season.

Pick: Packers (-1.5 at time of publishing)

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About the Author
Tyler Everett

Tyler Everett

Writer
Tyler Everett has been a sports writer since joining the student newspaper at his alma mater, NC State, back in 2008. He's covered sports and sports business for a number of newspapers and websites, including the Denver Broncos, Charlotte Observer, High Press Soccer, and Sports Business Journal, where he currently works full-time.

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