NFL Week 6 Odds: Cowboys-Eagles Betting Line Moves in Philly’s Favor is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

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Two huge tilts headline the NFL Week 6 slate, and we’re here to examine updated odds and betting line movements.

The Buffalo Bills remain a short road favorite vs. the Kansas City Chiefs in this week’s marquee matchup. The undefeated Philadelphia Eagles have been bet up and are laying a big number at home to the Dallas Cowboys in a battle for NFC East supremacy.

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NFL Week 6 Betting Lines: Updated Point Spreads, Totals, Moneylines

Here are updated Week 6 lines that can be found on sportsbook apps around the US.

Bet TypeSpreads
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Betting lines below are via DraftKings as of Friday morning.

San Francisco 49ers (-5, 44.5) at Atlanta Falcons

Slight move in Atlanta’s direction here after this game opened at 49ers -6. The Falcons are the only team in the NFL with a 5-0 ATS record. Keep an eye on the total here as it’s been bet up from 42.5. The under has cashed in seven of San Francisco’s last eight games.

New England Patriots at Cleveland Browns (-2.5, 43)

The Pats are 7-2 ATS in their last nine games against the Browns. Starting QB Mac Jones (ankle) was a limited participant in practice on Thursday. There’s a good chance that rookie Bailey Zappe will be under center again vs. the Browns. Zappe led New England to a 29-0 win over Detroit last week.

New York Jets at Green Bay Packers (-7.5, 45)

We included the Packers in our NFL Week 6 teaser and fully expect Green Bay to cover the adjusted -1.5 spread. But the Jets look like the right choice getting a TD and the hook here. New York is 4-1 ATS in its last five road games.

Jacksonville Jaguars at Indianapolis Colts (-2, 42)

It’s fun to look back and laugh sometimes. DraftKings was dealing the Colts -7 over the summer for this AFC South matchup. Fast forward to today and Indy is last in the league in scoring (13. 8 points per game) through Week 5. The Jags have covered their last five games against the Colts.

Minnesota Vikings (-3.5, 45.5) vs. Miami Dolphins

Miami has been a cover machine at home, going 7-1 ATS in its last eight as the host team. Will that change with third-string QB Skylar Thompson making his first career start against the Vikings?

Cincinnati Bengals (-2.5, 43) at New Orleans Saints

Cincy money has moved this from an opener of Bengals -1. It’s about time for the Bengals to put up some points. Cincinnati games have gone 5-0 to the Under this season.

Baltimore Ravens at New York Giants (-5.5, 45.5)

The Giants are typically involved in low-scoring games at home. They’ve gone Under in seven of the last eight at MetLife Stadium. But this total has been bet up a full two points from the opener. 

Tampa Bay Bucs at Pittsburgh Steelers (-8.5, 45.5)

Mike Tomlin has never had a losing season as head coach of the Steelers…yet. Tampa Bay’s defense could give rookie QB Kenny Pickett fits here. This game looks like an Under waiting to happen. Unders are 48-32 on the year and hitting at a 60% clip.

Carolina Panthers at Los Angeles Rams (-10, 41.5)

The hellscape that is Carolina Panthers football can’t get any worse. Or can it? P.J. Walker will get the start against the Rams, who are having some problems of their own in the wake of last season’s Super Bowl win.

Arizona Cardinals at Seattle Seahawks (-2, 50.5)

Some love for the home dog here after Arizona opened as a three-point favorite. DraftKings was dealing Seattle at +115 on the moneyline as of Friday.

Buffalo Bills (-2.5, 54) at Kansas City Chiefs

The Bills find themselves in the unfamiliar role of favorite against the Chiefs. You saw that stat about Patrick Mahomes in the role of underdog, right? Mahomes is 7-0-1 ATS in his career when the Chiefs are getting points.

It was about this time last year when Buffalo went into Kansas City and rolled, 38-20.

Eagles QB Jalen Hurts (AP Photo/Michael Ainsworth)

Dallas Cowboys at Philadelphia Eagles (-6.5, 42)

Eagles backers have moved this from an opener of Philly -5. This seems like a lot of points to give Dallas, which is 5-0 ATS in its last five road tilts.

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Denver Broncos at Los Angeles Chargers (-4.5, 45.5)

Fun fact: The Under has cashed in eight of the last nine games between these teams when Los Angeles is playing at home. Given Denver’s struggles on the offensive side of the ball and its relative strength on defense, the Under looks like the right play on MNF. 

Also read: NFL Week 6 Betting Strategies | Super Bowl 57 Odds | Cowboys vs. Eagles Odds and Prediction

About the Author
Kris Johnson

Kris Johnson

Senior Writer
Kris Johnson is a senior writer at Gaming Today with more than 15 years of experience as a sports journalist. Johnson's work has appeared in Sports Business Daily, Sports Business Journal, NASCAR Illustrated, and other publications. He also authored a sports betting novel titled The Endgame.

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