San Francisco 49ers vs. Green Bay Packers Odds: 2022 NFL Playoffs

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Deebo Samuel and the 49ers are underdogs at the Packers in the Divisional Round, per opening odds (Photo by Jevone Moore/Icon Sportswire)
SF 49ers vs GB Packers Odds NFL Odds

NFL · Sat (1/22) @ 8:15pm ET

SF 49ers at GB Packers
Lambeau Field, Green Bay, Wisconsin

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Packers vs. 49ers Opening Betting Lines

The Green Bay Packers, betting favorites to win Super Bowl 2022, begin their playoff push next weekend at Lambeau Field against the San Francisco 49ers. The Packers opened as 5.5-point chalk over their NFC rival at DraftKings, one of first sportsbooks in the betting market to post a number on this game. The spread dipped to -5 at DraftKings during the first few hours of wagering, while FanDuel was dealing -4.5.

The total was adjusted from 48.5 and 47.5 at DraftKings, and the opening moneyline had Packers -220/49ers +185.

The teams met at Levi’s Stadium in September, with Aaron Rodgers leading a last-ditch drive that resulted in a game-winning field goal as time expired. The Packers, 3-point underdogs in that Week 3 matchup, blew a 17-point lead before rallying for the 30-28 win.

San Francisco (11-7 SU, 10-8 ATS) reached the Divisional Round of these playoffs by upsetting the Dallas Cowboys on Sunday, 23-17, rewarding bettors who backed the underdog at +3.5 or +155 on the moneyline. The Niners jumped out to a 13-0 lead on Dallas, led 16-7 at the half, and held off a late Cowboys surge.

The Packers (13-4 SU, 12-5 ATS) rested up thanks to the first-round bye earned by posting the NFC’s top record.

*While the first of four Divisional Round games kicks off Saturday at 4:35 p.m. ET, dates and times for specific matchups are TBD.

49ers vs Packers Full Sportsbook Odds

Bet TypeSpreads
Open

49ers Lose Bosa

Shocking the Packers at Lambeau won’t be easy, especially if defensive end Nick Bosa is sidelined. Bosa suffered a head injury in the first half against Green Bay and didn’t return to the game.

Offensively, wide receiver Deebo Samuel is the catalyst for the 49ers, leading the team with 77 receptions in the regular season. Samuel tallied 14 touchdowns this regular season and scored a 26-yard TD in Sunday’s Wild Card victory. Elijah Mitchell is the top running back, gaining 963 yards to go with five TDs this and finding paydirt from five yards out in Dallas.

In addition to Samuel, the 49ers have a diverse receiving corps, as tight end George Kittle (six TDs) and receivers Brandon Aiyuk and Jauan Jennings (five TDs apiece) share the workload.

Packers Offense Thriving

As for the Packers, it all starts with Rodgers, who completed 366 of 531 for 4,115 yards this regular season. Rodgers has thrown 37 TDs against just four INTs and is the sizable favorite to  win his fourth MVP Award.

Davante Adams leads the receiving corps with 123 catches for 1,553 yards and 11 TDs. Allen Lazard (513 yards) has eight touchdowns on just 40 receptions.

AJ Dillon has rushed for 803 yards and five TDs to go along with two touchdown receptions. Aaron Jones has 799 yards and four TDs on the ground to go along with six TDs as a receiver.

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About the Author
Mark Ashenfelter

Mark Ashenfelter

Mark Ashenfelter is a Connecticut-based sportswriter and editor who has covered everything from NASCAR to the Philadelphia Phillies and Eagles. A life-long Philadelphia sports fan, in addition to Penn State football and the Baltimore Orioles, he's previously worked at ESPN, NASCAR Scene magazine and the Daily Local News in Chester County, PA.

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