Titans vs. Bills Odds & Prediction: Tough MNF Game Against Massive Underdog

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Here is a look at Titans vs. Bills odds on Monday Night Football and a prediction to conclude Week 2 of the 2022 NFL season.

Tennessee and Buffalo, which have won their divisions the past two years, will be jousting for the fifth straight season, with the underdog having prevailed in the past four meetings.

Included was the Titans’ bizarre 42-16 victory as a three-point home underdog in 2020. In that game which was pushed back to a Tuesday because of COVID issues, Tennessee had a 29-yard edge in average starting field position, matching the greatest margin for any team in the past seven years. The Titans had three TD drives of 18 yards or less.

MNF Odds: Point Spread, Moneyline, Total

Here are Monday Night Football odds from around the sports betting marketplace as the underdog looks to prevail for the fifth consecutive time.

TEN Titans vs BUF Bills Odds NFL Odds

NFL · Mon (9/19) @ 7:15pm ET

TEN Titans at BUF Bills
Bills Stadium, Orchard Park, New York

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Bills Aware of ‘Very, Very Tough’ MNF Game Against Titans

Last week, the Bills got the season rolling with a rousing 31-10 victory over the defending Super Bowl champion Rams in Los Angeles, outscoring their hosts 21-0 in the second half.

Bills quarterback Josh Allen (17) runs past Los Angeles Rams linebacker Justin Hollins in Buffalo’s 31-10 win. (AP Photo/John McCoy)

Ex-Ram Von Miller helped lead the defensive charge with two of Buffalo’s seven sacks of Matthew Stafford. The Bills also intercepted him three times.

The Titans, meanwhile, suffered a stunning home loss to the New York Giants, 21-20, as a five-point favorite while squandering a 13-0 second-half lead in the process.

Tennessee, though, had five sacks of Daniel Jones in that game on only 26 attempted passes despite going without their lead sack master (12) from last year, Harold Landry (IR, knee). Buffalo QB Josh Allen went down twice vs. the Rams.

Now for Tennessee’s offense: In last year’s meeting (a 34-31 Titans victory), standout Tennessee RB Derrick Henry, the rushing champ in 2019 and 2020, had his best game of the season vs. Buffalo. He averaged 7.2 yards a carry while generating 143 yards and scoring three TDs against the league’s top defense.

But over his past four games (wrapped around a foot injury that cost him the final nine games of last year’s regular season), he’s averaged only 3.0 yards on 98 carries. Against the Giants, though, his norm was 3.9 in gaining 82 yards.

The Bills, who are double-digit picks at some sites, were 4-1-1 against the spread (ATS) as such a heavy choice last season. The Titans, meanwhile are 2-0 straight up (SU) as such a big underdog in head coach Mike Vrabel’s five-year tenure, including a 28-12 romp over Baltimore in the 2019 postseason.

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Titans vs. Bills Betting Analysis & MNF Prediction

Unlike the past three meetings that were played in Nashville, this one will take place in Upstate New York. But the Bills aren’t unbeatable there, losing three times last season.

And although the Bills are enjoying the equivalent of having a near bye with 10 days since their opener at kickoff, it probably doesn’t have the same effect as such a break occurring at midseason.

And on the subject of top RBs running against Buffalo, Henry’s game last year was exceeded by 2021 rushing champ Jonathan Taylor, who had a season-high 185 yards and four TDs in a 41-15 rout of the Bills as a seven-point underdog. Hmm.

Thus, the Bills might have trouble pulling away while trying to contain a bulldozing running back. But it would be harder to fathom Tennessee QB Ryan Tannehill outdueling Buffalo’s Allen.

Prediction: Bills 31, Titans 27

Also read: Super Bowl 57 odds |Best NFL betting apps

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, has been a gaming writer (primarily the NFL) for almost four decades, with his work appearing in publications/websites across North America. He's a big fan of the Arkansas Razorbacks, Philadelphia's Eagles and Phillies, and inexplicably the NHL's Winnipeg Jets.

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