The new-look San Francisco 49ers (9-4 straight up, 8-5 against the spread) look for their sixth straight win and a playoff berth when they visit a crumbling Seattle Seahawks (7-6 SU, 6-7 ATS) team on Thursday Night Football.
Bettors can wager on player props and anytime touchdown scorer bets for this NFC West showdown to commence another exciting week of NFL betting. We’ve selected a few worth your consideration, including Christian McCaffrey making life miserable for the home team.
San Francisco 49ers vs. Seattle Seahawks TNF Odds
The 49ers lost four straight meetings versus Seattle before squashing them 27-7 in Week 2. Both teams are much-improved since their first encounter, but oddsmakers still see San Fran as the superior force.
The Niners (between -190 and -182 on the moneyline as of Wednesday morning) are 3- to 3.5-point road favorites against a hot-and-cold Seahawks team that has lost three of its last four contests. Bettors can grab the underdog with moneyline odds ranging from +150 and +160.
Seattle is 5-3 against the spread (ATS) as the underdog and 2-0 ATS as the home underdog. The 49ers, meanwhile, are 7-4 ATS as the favorite, but just 1-3 as the road favorite.
Most DraftKings bettors are siding with the Niners (75% of spread tickets and 79% of moneyline tickets).
The Over/Under total for this primetime divisional battle is set at 43.5 points on legal US sports betting apps.
Player Props, TD Scorer Bets for TNF Week 15
Christian McCaffrey Over 78.5 Rushing Yards (+100, DraftKings)
Christian McCaffrey has brought winning back to the Bay. After a lackluster debut against the Kansas City Chiefs, the dual-threat running back has since provided the offense with an effective running attack and has led the team to a five-game win streak.
McCaffrey is coming off his most efficient day on the ground this year, averaging 8.5 yards per carry (YPC) for a season-high 119 yards en route to a 35-7 victory over the Tampa Bay Buccaneers last week.
Given how dominant the Niners have looked in recent weeks (18-point average margin of victory over the past six games), it wouldn’t shock anyone if they burst to a huge lead and smother McCaffrey with carries.
He’s reached 79-plus rushing yards just twice in five starts with his new team, but the matchup is tailor-made for him to boom. The Seahawks allow the second most rushing yards on the ground (160.5 per game) and the fifth most yards per rush attempt (4.9), so it may be wise to ground and pound with McCaffrey.
As an added bonus toward McCaffrey’s potential production, “wide-back” Deebo Samuel will miss the next few games with a pair of injuries, which should afford a few extra carries to the team’s lead back.
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George Kittle Over 38.5 Receiving Yards (-115, BetMGM)
If QB Brock Purdy, who is dealing with an oblique injury, is able to make his second NFL start, he’ll face a hostile crowd under primetime lights. 49ers head coach Kyle Shanahan will want to give his young quarterback a simple playbook to work with, which includes short passes to his All-Pro tight end George Kittle.
Purdy threw only 21 passes in the team’s blowout win over the Bucs. Of those 21 attempts, five went to Kittle. He caught four of them for a total of 28 yards, but given the facts that this upcoming contest should be more even on the scoreboard and that Samuel is out, he should expect to see more targets and consequently more yards.
Another reason to back the Over on this receiving yards prop is that the game is on the road, where Kittle has posted his best outputs of the season. The veteran tight end is averaging 56.2 receiving yards per away game, compared to just 36.5 at Levi’s Stadium.
Kittle has fallen short of 42 yards receiving in each of his last three games, though he gets a great get-right opportunity against a Seahawks defense that hasn’t been able to game plan for tight ends all season. Seattle gives up the fourth most yards (60.6 yards per contest) to players at the position.
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Kenneth Walker III Under 49.5 Rushing Yards (-115, Caesars)
Running backs have nightmares about facing the 49ers, which is the by far league’s toughest run defense. San Francisco ranks first in rushing yards allowed (75.1 per game) and yards per rush attempt (3.4), and ranks second in rush attempts allowed (22.3).
The Niners held the entire Seahawks offense to just 36 yards rushing in Week 2. That was before Walker became the full-time starter after Rashaad Penny suffered a season-ending injury, but even a starting role won’t be enough to help him exceed his Week 15 rushing prop total.
The Niners haven’t given up 60-plus rushing yards to a single opposing player all year. They’ve also held the top rusher to Under 49.5 yards in nine of their 13 games. Before Rachaad White rushed for 56 yards last week, San Fran hadn’t given up more than 30 yards on the ground in six straight contests.
Kenneth Walker III Anytime TD Scorer (+165, Caesars)
Very few players have a true knack for finding the end zone. Kenneth Walker III is one of those players. Since taking over the starting role in the Seahawks’ backfield, the surprising rookie running back has scored in five of his first six starts, and has eight touchdowns in that six-game span.
The matchup is terrible in terms of yardage, but yards and efficiency don’t matter when you’re one of the league’s best scorers on the ground. Walker totaled 51 yards on 18 carries (2.83 YPC) against the New York Giants in Week 8, yet he still managed to hit paydirt. Against the Los Angeles Rams in Week 12, he logged 26 yards on 14 carries (1.86 YPC) to go along with a pair of touchdowns.
Walker might be in for 10-15 carries for only a few dozen yards Thursday night, but once the Seahawks offense gets close to or inside red zone territory, there’s no stopping No. 9 from scoring six points.