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The NFL Week 4 odds for 2026 are out, giving fans and bettors a look at the point spreads, moneylines, and over/under totals for all 16 games. With the Steelers facing the Browns on Thursday Night Football and several key divisional matchups coming on Sunday, the latest NFL betting lines offer plenty to analyze.
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Below, we break down the Week 4 NFL lines and spreads for every game, so you can compare the odds, track line movements, and see how sportsbooks view each matchup. Odds can change before kickoff, so check the latest numbers before placing a bet.
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Baltimore is laying 11.5 points to Tennessee, the biggest number of NFL Week 4, and Minnesota is laying 10.5 to Miami. Be careful with both. In each of the first three weeks, a favourite laying 8 or more has lost outright.
Week 4 opens tonight with Steelers at Browns and includes a 9:30 a.m. ET kickoff in London. The bigger story is two spreads that flipped by four to five points since they opened, both because of quarterback injuries. Here are the current odds for every game.
Odds were checked on 1 October and move constantly. Confirm the current number at your sportsbook before acting on anything here.
NFL Week 4 Odds: Full Board
| Matchup | Spread | Total | When |
|---|---|---|---|
| Steelers at Browns | PIT -2.5 | 38.5 | Thu, Prime Video |
| Colts vs Commanders (London) | IND -3.5 | 47 | Sun 9:30 a.m. ET, NFL Network |
| Cardinals at Giants | ARI -1.5 | 44.5 | Sun |
| Cowboys at Texans | HOU -2.5 | 47.5 | Sun |
| Packers at Buccaneers | GB -4 | 39.5 | Sun |
| Jaguars at Bengals | CIN -2.5 | 51.5 | Sun |
| Rams at Eagles | LAR -3 | 43.5 | Sun |
| Patriots at Bills | BUF -6.5 | 48.5 | Sun |
| Jets at Bears | CHI -3.5 | 42.5 | Sun |
| Titans at Ravens | BAL -11.5 | 43.5 | Sun |
| Dolphins at Vikings | MIN -10.5 | 38.5 | Sun |
| Broncos at 49ers | SF -2.5 | 47.5 | Sun |
| Chiefs at Raiders | KC -4.5 | 47.5 | Sun |
| Chargers at Seahawks | SEA -7 | 42.5 | Sun |
| Lions at Panthers | DET -3.5 | 50.5 | Sun 8:20 p.m. ET, NBC |
| Falcons at Saints | NO -2.5 | 48.5 | Mon, ESPN |
Spreads and totals are the consensus on 1 October. Some books differ by half a point: Seattle is -6.5 at several, Green Bay is -3.5 at others, and Arizona ranges from -1 to -2.5.
The Biggest Numbers, and the Warning Attached
Ravens -11.5 vs Titans is the largest spread of the week. Vikings -10.5 vs Dolphins is next.
Both are defensible on paper. Baltimore is the better team, and Minnesota’s defence is strong. But look at what happened to big favourites so far:
- Week 1: Arizona beat the Chargers 26-14 outright as an 11.5-point underdog.
- Week 2: Cleveland beat Tampa Bay 23-19 outright at +8.
- Week 3: Washington beat Seattle 33-31 outright at +8.5.
Three straight weeks. Philadelphia, a road favourite, also lost 27-7 in Chicago on Monday night. That does not make Baltimore or Minnesota bad bets. It is the context this board is being read in.
Baltimore also plays at home a week after the NFL’s first game in Rio de Janeiro. Miami has also lost De’Von Achane for the season, according to reports, and Minnesota’s Justin Jefferson is dealing with an ankle injury.
The Two Lines That Flipped
Quarterback injuries produced the biggest movement on the board. Both moved through zero, which means the favourite changed.
Packers at Buccaneers: from TB -1.5 to GB -4
DraftKings opened Tampa Bay as a 1.5-point home favourite on 27 September. The Packers are now favoured by 3.5 to 4 on the road. That is a swing of about five points.
The cause is Baker Mayfield’s thumb injury. Tampa Bay is preparing rookie Jalon Daniels for what would be his first NFL start, according to reports. Green Bay also played on Thursday last week, so it has extra rest.
Cardinals at Giants: from NYG -2.5 to ARI -1.5
The Giants opened as 2.5-point home favourites. Arizona is now favoured by about 1.5, a four-point swing. New York has lost quarterback Jaxson Dart to a knee injury and pass rusher Brian Burns, and it scored no touchdowns against Tennessee last week.
Both moves tell the same story. A line that has swung all the way through zero has already absorbed the news. If you are looking for an edge here, it is probably gone.
London: A 9:30 A.M. Kickoff
Colts vs Commanders, IND -3.5, total 47. This is the first of three NFL games in London this season, at Tottenham Hotspur Stadium. Washington is the designated home team. It airs on NFL Network.
The total is the interesting number. Washington’s games have averaged about 55.7 combined points this season, and Indianapolis was involved in back-to-back games of 64 and 63 combined points before last week’s lower-scoring divisional game. A total of 47 sits well below the pace both teams have set.
Jayden Daniels is expected to travel and work toward a return, according to reports. His final status will move this line. Because kickoff is so early, the inactive list arrives around 8:00 a.m. ET on Sunday.
Totals: The High and the Low
- Highest: Jaguars at Bengals, 51.5. Followed by Lions at Panthers on Sunday night at 50.5.
- Lowest: Steelers at Browns and Dolphins at Vikings, both 38.5. Packers at Buccaneers is next at 39.5.
The bottom of the board is full of quarterback and skill-player questions. Quarterback uncertainty tends to push totals down, because books price in a worse offence while the situation is unresolved.
Moneylines Worth Knowing
These come from bet365 as of 29 September and move constantly:
- Titans +475, Ravens -650.
- Dolphins +400, Vikings -550.
- Patriots +250, Bills -310.
- Chargers +250, Seahawks -310.
- Steelers -155, Browns +130.
- Colts -180, Commanders +150.
Check live prices before betting any of these. Several spreads moved by half a point after those moneylines were posted.
What Week 3 Told the Market
- Underdogs keep winning outright. Washington at +8.5 beat Seattle, and Atlanta blew out Green Bay in Week 3 after the Packers line collapsed during the week.
- Road favourites are not safe. Philadelphia lost 27-7 at Chicago on Monday night. The Eagles now host the Rams as 3-point underdogs.
- Quarterback health moves lines more than form. Both of the biggest Week 4 moves are quarterback injuries rather than results.
How to Read the Week 4 Board
- Check the number, then the price. A -3 at -105 and a -3 at -120 are different bets.
- Respect the key numbers. Seattle at -7 and Los Angeles at -3 sit exactly on them. A seven-point Seahawks win or a three-point Rams win pushes rather than covers.
- Treat flipped lines as priced. Green Bay and Arizona have already moved through zero.
- Check Friday designations. Four starting quarterback situations are live this week. Our Week 4 news roundup covers each.
- Shop the number. Half a point across books matters more at 3 and 7 than anywhere else.
New to any of this? Our guide to reading NFL odds explains spreads, totals and moneylines in plain English. For our selections, see our Week 4 best bets, and for a call on every game see our NFL picks this week.
Frequently Asked Questions
What is the biggest spread in NFL Week 4?
Baltimore at -11.5 against Tennessee. Minnesota is next at -10.5 against Miami. A favourite laying 8 or more has lost outright in each of the first three weeks.
What is the highest total in Week 4?
Jaguars at Bengals at 51.5 points. Lions at Panthers on Sunday night is next at 50.5. The lowest are Steelers at Browns and Dolphins at Vikings at 38.5.
Why did the Packers line flip?
Tampa Bay opened as a 1.5-point favourite, and Green Bay is now favoured by 3.5 to 4. Baker Mayfield’s thumb injury is the cause, with rookie Jalon Daniels preparing for a first start.
What time is the NFL London game in Week 4?
Colts vs Commanders kicks off at 9:30 a.m. ET on Sunday 4 October at Tottenham Hotspur Stadium and airs on NFL Network. Indianapolis is a 3.5-point favourite.
Which Week 4 game opens the week?
Steelers at Browns on Thursday night, streaming on Prime Video. Pittsburgh is a 2.5-point favourite and the total is 38.5.
Which Monday night game is on the Week 4 schedule?
Falcons at Saints on ESPN. New Orleans is a 2.5-point home favourite with a total of 48.5.
Odds are subject to change and were accurate at the time of writing. Always confirm the current line at your sportsbook before placing a wager. You must be 21 or older and physically located in a state where sports betting is legal. Nothing here is a guarantee of any outcome. Please gamble responsibly. If gambling stops being fun, call 1-800-GAMBLER for confidential support.
