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Lamar Jackson has only an outside chance to play Sunday night, and Atlanta just scored 45 points on Monday night. That is the biggest betting story of NFL Week 5, and it is one of six quarterback and star situations still unresolved.
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Game Lines, Prop Bets & Parlays for Days
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Game Lines, Prop Bets & Parlays for Days
Here is the latest Week 5 news, organised by what it does to the betting lines, with Sunday’s final designations still to come.
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Injury designations change daily, so treat every status here as a snapshot. Confirm the final inactives roughly 90 minutes before each kickoff.
The Six Situations Moving Week 5 Lines
| Player | Status | Game | Line |
|---|---|---|---|
| Lamar Jackson (Ravens QB) | Ankle sprain. Outside chance to play | At Falcons, Sunday night | BAL -3.5 at the open. Will move |
| Jayden Daniels (Commanders QB) | Elbow dislocation. Hoped to return | Vs Giants | WAS -3 |
| Ja’Marr Chase (Bengals WR) | Concussion protocol | At Dolphins | CIN -7.5, down from -8.5 |
| Saquon Barkley (Eagles RB) | Hamstring. Week to week | Vs Jaguars, London | JAX -5.5, up from -3 |
| Baker Mayfield (Buccaneers QB) | Thumb. Out | At Cowboys, Thursday | DAL -10 |
| Caleb Williams (Bears QB) | Hamstring. Reported out for several weeks | At Packers | CHI -3 |
1. Ravens: Lamar Jackson’s Ankle
Jackson left Sunday’s 24-18 win over Tennessee after the second quarter and did not return. NFL Network’s Ian Rapoport reported on Tuesday that he has only an outside chance to play at Atlanta, and that the injury could keep him out for multiple games depending on his rehab.
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If Jackson cannot go, Tyler Huntley starts for the first time this season. Huntley went 8-of-9 for 63 yards in relief, but the offence produced no points and five first downs across five drives.
Line impact: Baltimore opened as a 3.5-point favourite and the number had not moved before the news. It is now unreliable. The Falcons also won 45-24 on Monday night, so books are weighing a hot Atlanta team against an uncertain Baltimore quarterback. Wait for last minute.
2. Commanders: Jayden Daniels and a Backup Problem
Washington hopes Jayden Daniels can return from an elbow dislocation after a “huge positive step” in practice, according to head coach Dan Quinn. Marcus Mariota, who started in Daniels’ place, left Sunday’s 30-13 loss to the Colts with a knee injury. Quinn said it is believed to be an MCL injury and would be evaluated further.
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If Daniels cannot play, rookie Athan Kaliakmanis, who relieved Mariota in London, could start.
Line impact: Washington is a 3-point favourite over the Giants, who beat Arizona 36-24 last week. The spread assumes the better quarterback scenario. If Daniels sits, expect it to shrink.
3. Bengals: Ja’Marr Chase and Tee Higgins
Chase left the second quarter of Sunday’s 22-17 loss to Jacksonville with a concussion and is in the league’s protocol. Tee Higgins suffered an adductor injury late and is considered day-to-day. Mitch Tinsley was the only other Bengals wide receiver to see snaps behind them.
Line impact: Cincinnati opened as an 8.5-point favourite over the Dolphins and the line is now 7.5, while the total fell from 46.5 to 42.5. Miami is 0-4, so the market still trusts the Bengals, but it has taken both receivers’ injuries into account.
4. Eagles: Saquon Barkley’s Hamstring
Barkley left the first half of Sunday’s 24-20 loss to the Rams and is considered week to week. Philadelphia led 20-10 at halftime and did not score again. Linebacker Jonathan Greenard (ankle) also left, and cornerback Quinyon Mitchell (knee) did not return. Offensive tackle Lane Johnson and receiver DeVonta Smith were inactive for the game.
Line impact: The Eagles are 0-4 against the spread and travel to London to face a Jaguars team that is 3-1 against it. The spread opened at 3 and has climbed to 4.5 or more, and the total dropped by a point.
5. Buccaneers: Still Without Baker Mayfield
Mayfield is out with a dislocated thumb, and one injury tracker projects a return around Weeks 6 to 9. That is an outside estimate, not a team timeline. Undrafted rookie Jalon Daniels is the quarterback, and Tampa Bay is 0-4 and 0-4 against the spread.
Line impact: Dallas opened at -9.5 and moved to -10 for Thursday night. The Cowboys, 3-1 against the spread, have gone over the total in each of their four games.
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6. Bears: Caleb Williams Is Still Out
Williams was reported out three to four weeks with a Grade 2 hamstring injury suffered in Week 2. CBS Sports carries a report that Tyson Bagent is set to start against Green Bay, so confirm who is under centre when the inactives are released.
Line impact: Chicago moved from -1.5 to -2.5 and beyond, and is 3-1 straight up and against the spread. Green Bay is 1-3 against it, but 6-2 as a home underdog under Matt LaFleur.
Other Injury News Worth Watching
- Broncos: cornerbacks Patrick Surtain II (ankle) and Riley Moss (ribs) were ruled out of Sunday’s loss to the 49ers. Denver is a road favourite at the Chargers.
- Vikings: offensive lineman Donovan Jackson (knee) was ruled out, and Christian Darrisaw was evaluated for a concussion. Justin Jefferson missed Week 4.
- Jaguars: safety Caleb Ransaw (knee) did not return.
- Seahawks: defensive tackle Leonard Williams left late in the win over the Chargers.
- Texans: cornerback Jaylin Smith (hamstring) was ruled out of the loss to Dallas.
- Jets: Breece Hall and Adonai Mitchell were inactive in Week 4.
- Patriots: cornerback Christian Gonzalez was inactive in Week 4.
Several of these players have not had their Week 5 status confirmed, so watch the practice reports on Wednesday and Thursday.
Who Is Hot Going Into Week 5
- Falcons: a 45-24 rout of New Orleans on Monday night, with Michael Penix Jr. back at quarterback.
- Vikings and 49ers: both 4-0. Minnesota beat Miami 15-10 and San Francisco beat Denver 24-14.
- Chiefs: 4-0 after beating the Raiders, and on bye this week.
- Browns: 3-1 after beating Pittsburgh on Thursday.
Five teams are winless: the Dolphins, Buccaneers, Titans, Texans and Chargers.
What Week 4 Changed
- Seven underdogs won outright: the Browns, Giants, Cowboys, Jaguars, Patriots, Panthers and Falcons.
- Double-digit favourites won but did not cover. Baltimore beat Tennessee 24-18, and Minnesota beat Miami 15-10.
- New England beat Buffalo 29-26 and moved to 2-2. Carolina beat Detroit 32-26.
For the current board, see our Week 5 best bets. For our selections, see our Week 5 best bets, and for this week’s sportsbook offers see our NFL betting promos this week.
Week 5 Schedule
| Day | Date | Games |
|---|---|---|
| Thursday | 8 October | Buccaneers at Cowboys, 8:15 p.m. ET, Prime Video |
| Sunday | 11 October | Eagles vs Jaguars in London at 9:30 a.m. ET on NFL Network, then 12 more games, with Ravens at Falcons on Sunday night |
| Monday | 12 October | Bills at Rams, 8:15 p.m. ET, ESPN |
The Chiefs and Panthers are on bye. Full season detail is in our 2026 NFL schedule hub.
Frequently Asked Questions
Is Lamar Jackson playing in Week 5?
Not confirmed. He sprained his ankle in Week 4 and has only an outside chance to play at Atlanta, according to NFL Network. Tyler Huntley would start if he cannot.
Is Jayden Daniels playing in Week 5?
Unresolved. Washington hopes he can return from an elbow dislocation after he returned to practice. Marcus Mariota hurt his knee, so rookie Athan Kaliakmanis could start if Daniels cannot.
Is Ja’Marr Chase playing in Week 5?
He is in the concussion protocol, so his status is in doubt. Tee Higgins, who hurt his adductor, is day-to-day.
Who is starting at quarterback for the Bears?
Caleb Williams is reported out for several weeks with a hamstring injury. CBS Sports reports Tyson Bagent is set to start. Confirm when the inactives are released.
Is Baker Mayfield playing Thursday?
No. He is out with a dislocated thumb, and rookie Jalon Daniels is the Buccaneers’ quarterback.
When do final NFL injury designations come out?
Friday, which is why this article is refreshed then. The definitive list is the inactives, released roughly 90 minutes before each kickoff.
Injury statuses change and were accurate at the time of writing. Always check the latest official team reports and the inactives list before acting on anything here. If you are betting on these games, you must be 21 or older and located in a state where sports betting is legal. Please gamble responsibly. If gambling stops being fun, call 1-800-GAMBLER for confidential support.
