49ers vs. Seahawks Odds & Prediction: Make This Bet on the NFC West Rivalry on TNF

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The San Francisco 49ers are scheduled to face the Seattle Seahawks on Thursday Night Football to kick off Week 15 of the 2022 NFL season.

The 49ers, who have the longest current win streak in the league at six games, are 3.5-point favorites across the board at DraftKings, FanDuel, BetMGM, and PointsBet in this battle between NFC West rivals.

Let’s take a look at our 49ers vs. Seahawks odds on Thursday Night Football, as well as a prediction.

TNF Odds: Point Spread, Moneyline, Total

Here are Thursday Night Football odds from around the sports betting marketplace.

49ers-Seahawks NFC West Rivalry on TNF

San Francisco (9-4 straight up/8-5 against the spread) has the opportunity to clinch the division crown and at least a No. 3 seed in the NFC with a victory versus the Seahawks.

Seattle (7-6 SU/6-7 ATS), which held a 1.5-game lead over the 49ers after Week 9 play, has since lost three of four and not only are two games behind San Francisco in the West but half a game out in the conference wild-card mix.

This meeting is a rematch of their Week 2 game in San Francisco, which was won by the 49ers, 27-7. It’s the most lopsided loss of the season for the Seahawks, whose other five defeats are by seven points or fewer. Seattle’s only score was the result of an 86-yard return of a blocked FG attempt.

The 49ers are fresh off a rousing 35-7 victory over Tampa Bay in rookie QB Brock Purdy’s first start after coming in for injured Jimmy Garoppolo (foot) a week earlier. Purdy’s passer rating of 134.0 was the best for any QB last week.

The 49ers, like the Seahawks, have serious injury issues regarding key offensive weapons.

Star 49ers receiver Deebo Samuel suffered a left MCL sprain and sprained left ankle last week and will miss this game. Head coach Kyle Shanahan said he hopes Samuel will return before the playoffs commence.

49ers vs. Seahawks Odds & Prediction: Make This Bet on the NFC West Rivalry on TNF
Injuries will be a major factor in Week 15, so check out our 49ers vs. Seahawks odds & prediction on Thursday Night Football.  (AP Photo/Jed Jacobsohn)

Another injury worth keeping an eye on is RB Christian McCaffrey’s knee issue that limited him in Monday’s drills. He’s listed as questionable. On Sunday, though, he had 119 rushing yards and didn’t appear to be hobbling. Already on IR is the 49ers’ leading rusher from last season, Elijah Mitchell (knee).

Then there’s this: Purdy also is listed as questionable (ribs, oblique) after taking a hit in last week’s game. The team is awaiting the result of an MRI to help determine his status for Thursday. And if he can’t go, 36-year-old Josh Johnson would step in as San Francisco’s fourth starting QB of the season, tying a team record that is one off the NFL mark.

Johnson is the ultimate journeyman, having been with a league-record 14 teams in a career that dates back to 2008. He’s started nine games in that span and has a 1-8 record.

As for Seattle, QB Geno Smith hasn’t missed a beat this season, ranking third on the passer-rating chart and starting each game.

The running game has been hit hard, with their top three RBs dealing with ankle injuries that kept each out of action last week in a 30-24 upset home loss to Carolina.

NFL Offensive Rookie of the Year candidate and Seattle’s leading rusher, Kenny Walker (+260 at FanDuel), is listed as day-to-day with a sprain. Last year’s top ground gainer for the Seahawks with a 6.3-yard average per carry, Rashaad Penny, suffered a broken left fibula and sprained ankle two months ago and hasn’t returned to drills. And, even little-used DeeJay Dallas is questionable.

Without those guys last week, Seattle had only 46 rushing yards on 14 carries versus Carolina.

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49ers vs. Seahawks TNF Prediction

Even with no injury issues at running back in that Week 2 meeting in SF, the Seahawks were stymied on the ground with a season-low 36 rushing yards. Not by coincidence, Smith had his worst passer-rating game of the season in that outing.

If the Seahawks could get only 46 ground yards last week against a Carolina defense that ranks 20th in yards allowed per carry (4.5), how will Seattle fare against San Francisco, which yields a league-low 3.4 a rush?

Speaking of run defense, the Seahawks have struggled mightily in their past four games, giving up 209.5 yards a game. That puts them at No. 31 in the league for the season.

Even if Johnson gets the start…

Prediction: 49ers 26, Seahawks 13

Also read: NFL Week 15 odds | 2023 NFL playoffs odds

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, is a sports betting writer at Gaming Today. He has been a gaming writer (primarily for the NFL) for more than four decades, with his work appearing in publications and websites across North America. Christ is a big fan of the Arkansas Razorbacks, Philadelphia Eagles and Phillies, and the NHL's Winnipeg Jets.

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