49ers vs. Seahawks Odds & Prediction: Make This Bet on the NFC West Rivalry on TNF

San Francisco (9-4 straight up/8-5 against the spread) has the opportunity to clinch the division crown and at least a No. 3 seed in the NFC with a victory versus the Seahawks.

Seattle (7-6 SU/6-7 ATS), which held a 1.5-game lead over the 49ers after Week 9 play, has since lost three of four and not only are two games behind San Francisco in the West but half a game out in the conference wild-card mix.

This meeting is a rematch of their Week 2 game in San Francisco, which was won by the 49ers, 27-7. It’s the most lopsided loss of the season for the Seahawks, whose other five defeats are by seven points or fewer. Seattle’s only score was the result of an 86-yard return of a blocked FG attempt.

The 49ers are fresh off a rousing 35-7 victory over Tampa Bay in rookie QB Brock Purdy’s first start after coming in for injured Jimmy Garoppolo (foot) a week earlier. Purdy’s passer rating of 134.0 was the best for any QB last week.

The 49ers, like the Seahawks, have serious injury issues regarding key offensive weapons.

Star 49ers receiver Deebo Samuel suffered a left MCL sprain and sprained left ankle last week and will miss this game. Head coach Kyle Shanahan said he hopes Samuel will return before the playoffs commence.

Another injury worth keeping an eye on is RB Christian McCaffrey’s knee issue that limited him in Monday’s drills. He’s listed as questionable. On Sunday, though, he had 119 rushing yards and didn’t appear to be hobbling. Already on IR is the 49ers’ leading rusher from last season, Elijah Mitchell (knee).

Then there’s this: Purdy also is listed as questionable (ribs, oblique) after taking a hit in last week’s game. The team is awaiting the result of an MRI to help determine his status for Thursday. And if he can’t go, 36-year-old Josh Johnson would step in as San Francisco’s fourth starting QB of the season, tying a team record that is one off the NFL mark.

Johnson is the ultimate journeyman, having been with a league-record 14 teams in a career that dates back to 2008. He’s started nine games in that span and has a 1-8 record.

As for Seattle, QB Geno Smith hasn’t missed a beat this season, ranking third on the passer-rating chart and starting each game.

The running game has been hit hard, with their top three RBs dealing with ankle injuries that kept each out of action last week in a 30-24 upset home loss to Carolina.

NFL Offensive Rookie of the Year candidate and Seattle’s leading rusher, Kenny Walker (+260 at FanDuel), is listed as day-to-day with a sprain. Last year’s top ground gainer for the Seahawks with a 6.3-yard average per carry, Rashaad Penny, suffered a broken left fibula and sprained ankle two months ago and hasn’t returned to drills. And, even little-used DeeJay Dallas is questionable.

Without those guys last week, Seattle had only 46 rushing yards on 14 carries versus Carolina.