Chiefs vs. Chargers Odds & Prediction: TNF Betting Line Moves Toward KC is an independent sports news and information service. has partnerships with some of the top legal and licensed sportsbook companies in the US. When you claim a bonus offer or promotion through a link on this site, Gaming Today may receive referral compensation from the sportsbook company. Although the relationships we have with sportsbook companies may influence the order in which we place companies on the site, all reviews, recommendations, and opinions are wholly our own. They are the recommendations from our authors and contributors who are avid sports fans themselves.

For more information, please read How We Rank Sportsbooks, Privacy Policy, or Contact Us with any concerns you may have.

Gaming Today is licensed and regulated to operate in AZ, CO, CT, IN, KS, LA, MI, NJ, NY, PA, TN, and VA.

In a battle of AFC West heavyweights, the Los Angeles Chargers are set to take on the Kansas City Chiefs on Thursday Night Football in Week 2.

In Chiefs vs. Chargers odds, most sportsbooks opened Kansas City -3, but KC climbed to as high as -4.5 on some oddsboards by midweek.

Chargers star wide receiver Keenan Allen (hamstring) has been ruled out for this matchup and it will be a tough task for the road underdogs to pick up a win on short rest.

Let’s take a look at the latest TNF odds as well as our Chiefs vs. Chargers prediction.

TNF Odds: Point Spread, Moneyline, Total

Here are Thursday Night Football odds from around the sports betting marketplace as the Chiefs look to continue their dominance at Arrowhead Stadium.

LA Chargers vs KC Chiefs Odds NFL Odds

NFL · Thu (9/15) @ 8:15pm ET

LA Chargers at KC Chiefs
Arrowhead Stadium, Kansas City, Missouri

Bet TNF at DraftKings: $50 Free Bet + $1,000 Bonus

Chiefs-Chargers Looking to Claim Early Sole Possession of AFC West

The two kingpins of the AFC West meet at Kansas City’s Arrowhead Stadium with the victor claiming sole possession of the division lead.

Although the Chiefs are 27-6 at home the past four years in the regular season, they are 1-3 against the Chargers. This includes LA’s 30-24 win in Week 3 last season (7.5-point underdog) as the Chargers benefited from a plus-4 edge in turnovers in that victory.

chargers chiefs odds
Travis Kelce and Chiefs have seen odds move in their direction for the Week 2 TNF game against Nasir Adderley and the Chargers (AP Photo/Kyusung Gong)

Last week, Kansas City had a league-best 33 first downs in a 44-21 win against the Arizona Cardinals, with Patrick Mahomes throwing for five TDs with no interceptions. QBs had six such 5/0 games in the league last year, and Mahomes had one of them in a 41-14 road win against the Las Vegas Raiders.

LA opened with a 24-19 home victory over Las Vegas as a 3.5-point choice and intercepted Derek Carr three times.

Although Kansas City won the West by three games over LA in 2021, had the host Chargers won and not blown a 28-21 lead in the final 1:16 and then tumbled in OT 34-28 in Week 15, they would have tied the Chiefs for the division lead and owned the head-to-head tiebreaker with three games left.

Bet TNF at BetMGM: Use promo code TODAY for $1,000 Risk-Free Bet

Chiefs vs. Chargers Prediction: Chiefs -4.5

Unlike last year when the Chiefs were breaking in an inexperienced offensive line and got off to a 3-4 start, they have one of the league’s best units this season, which only makes the job easier for Mahomes, who didn’t get dropped on 39 drop-backs last week.

But he better have his head on a swivel this week since LA had five sacks last week vs. Las Vegas, including three by Khalil Mack. One of which was a late fourth-down strip sack of Carr.

One injury note, though, is that ORG Trey Smith is questionable (ankle). He was a sixth-round pick last year out of Tennessee.

With regard to the Chargers, this is a particularly bad week for them to be without All-Pro corner J.C. Jackson, who is day-to-day after recent ankle surgery. But without him last week, LA still had those three INTs.

Also, veteran LA receiver Keenan Allen (hamstring) hobbled off the field against the Raiders last week after catching all four targeted throws from Justin Herbert, including one for 42 yards. He’s also unlikely to play.

One more thing that works against the Chargers: the league schedule makers gave them a mini atomic wedgy by having them travel east across two time zones on three days’ rest. No other team is scheduled to travel across even one time zone east on such short rest.

Prediction: Chiefs 31, Chargers 21

Also read: Thursday Night Football Props | Super Bowl 57 odds |Best NFL betting apps

About the Author
Bob Christ

Bob Christ

Bob Christ, based in New Mexico, has been a gaming writer (primarily the NFL) for almost four decades, with his work appearing in publications/websites across North America. He's a big fan of the Arkansas Razorbacks, Philadelphia's Eagles and Phillies, and inexplicably the NHL's Winnipeg Jets.

Get connected with us on Social Media