This is a monster matchup week in the NFL with Chiefs-Buccaneers, Rams-49ers, and Bills-Ravens all on the slate. Let’s examine NFL Week 4 odds and line movements across the sports betting industry.
Week 4 kicked off Thursday night with the Cincinnati Bengals defeating the Miami Dolphins, 27-15.
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NFL Week 4 Betting Lines: Updated Point Spreads, Totals
Here are live odds from legal US sportsbooks on the Week 4 slate.
Here’s a game-by-game look at NFL Week 4 odds, current at DraftKings as of Friday, Sept. 30.
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Chiefs at Buccaneers (-1, 46)
This line flipped after opening at KC -2.5 on Sunday. When the NFL schedule was released in May, the Bucs were installed as a -2.5 favorite at home. The total was bet down from an opener of 47.5 during the week.

Rams at 49ers (-1.5, 42.5)
Slight move in the direction of the Rams after the 49ers opened at -2. But the biggest movement is on the total, which dropped from 47 all the way to 42.5.
Another titillating tilt here. San Francisco had LA’s number in the regular season last year, winning and covering both games before losing to the Rams in the NFC Championship game.
The Rams will try to snap a three-game losing streak at Levi’s Stadium.
Bills (-3, 51) at Ravens
Another total that’s been bet down here from 54.5 over the course of the week. As for the side, this game has seen solid two-way action with 51% of the of the bets and handle on the Bills at FanDuel.
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Vikings (-3, 43) at Saints
London calling! Some Minnesota money pushed this line from Vikings -2 to a field goal at DraftKings. Minnesota has attracted a whopping 87% of the bets and 91% of the handle at FanDuel, which was offering the Vikings at -2.5 (-112) as of Friday.
Commanders at Cowboys (-3, 41)
This will mark the second NFC East divisional game for Dallas after its MNF win against the Giants. Fun fact: The Cowboys were a perfect 6-0 ATS in divisional games last year.
Seahawks at Lions (-4, 48)
Seattle received some support during the week after this game opened at Detroit -6.
Broncos at Raiders (-2.5, 45.5)
This line ticked up from an opener of Las Vegas -1.5. The Raiders, who were expected to be an AFC West threat the season with Davante Adams, are 0-3 overall and ATS.
Titans at Colts (-3.5, 43)
Indy opened at -3 here. We’ll see if the Colts can back up their Week 3 win over KC by beating last year’s AFC South champion. The Titans (+146) have garnered 81% of the bets on the moneyline at FanDuel.
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Patriots at Packers (-9, 40.5)
The Packers are a popular pick in Survivor Pools this week. Mac Jones (ankle) is out for the Patriots and backup Brian Hoyer will start at QB. This line had moved all the way to Green Bay -11 at several sportsbooks including DraftKings, PointsBet, and Caesars as of Monday morning before leveling off during the week.
Browns (-1, 47.5) at Falcons
This line ticked down from an opener of Cleveland -3, and the total jumped two points this week. That’s due in part to the uncertain status of Browns DE Myles Garrett, who suffered minor injuries in a car accident on Monday. Garrett, who was reportedly at the practice facility Thursday, did not participate in drills and his status is unknown.
Cardinals (-1, 43.5) at Panthers
This line flipped from an opener of Carolina -1. At FanDuel, bettors are hammering Arizona (+100) on the moneyline with 90% of the bets and 85% of the handle on the Cardinals.
Jaguars at Eagles (-6.5, 45.5)
Philadelphia opened here at -7. After manhandling the Colts and Chargers, in successive weeks, Jacksonville is still a decisive dog against Philadelphia.
Road dogs are hitting at nearly a 60% clip so far this season, and this could be a sneaky good game. Former Eagles coach Doug Pederson returns to Philadelphia as head coach of Jacksonville.
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